About   Help   FAQ
Plek
Gene Detail
Symbol

Name
ID
Plek
pleckstrin
MGI:1860485
Synonyms
2010300B13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
9.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:16971206-17052381 bp, - strand
From VEGA annotation of GRCm38

  81176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2000  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: pleckstrin
Gene Tree: Plek

Human
homologs
Human Homolog PLEK, pleckstrin
NCBI Gene ID 5341
neXtProt AC  NX_P08567
Human Synonyms  P47
Human Chr (Location)  2p13.3; chr2:68365190-68397453 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display mild thrombocytopenia, impaired platelet aggregation, and impaired platelet granule secretion.
 
Interactions
Plek interacts with 324 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process actin cytoskeleton reorganization, cell projection organization, ...
Component cell, cytoplasm, ...
Function phosphatidylinositol-3,4-bisphosphate binding, protein homodimerization activity, ...
External Resources: FuncBase
Expression
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005189 (Evidence)
Ensembl Gene ModelENSMUSG00000020120 (Evidence)
Entrez Gene56193 (Evidence)
DFCITC1591284, TC1577626, TC1632171
DoTSDT.55118950, DT.489155
NIA Mouse Gene IndexU032535
PDB1UHW
Consensus CDS ProjectCCDS24446.1
International Mouse Knockout Project StatusPlek
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005189 VEGA Gene Model | MGI Sequence Detail 81176 C57BL/6J ±  kb
transcript OTTMUST00000011599 VEGA | MGI Sequence Detail 4101 Not Applicable 
polypeptide OTTMUSP00000005390 VEGA | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(9)
Polymorphisms
PCR(1) : SNPs within 2kb(415 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000591 DEP domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000012851 pleckstrin
References
(Earliest) J:59221 Cmarik JL, et al., cDNA cloning and mapping of mouse pleckstrin (Plek), a gene upregulated in transformation-resistant cells. Genomics. 2000 Jun 1;66(2):204-12
(Latest) J:148429 Lian L, et al., Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood. 2009 Apr 9;113(15):3577-84
All references(24)
Other
accession IDs
MGI:1917248

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory