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Plek Gene Detail
Summary
  • Symbol
    Plek
  • Name
    pleckstrin
  • Synonyms
    2010300B13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860485
    NCBI Gene: 56193
Location & Maps
more
  • Sequence Map
    Chr11:16971206-17052381 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      81176 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PLEK, pleckstrin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLEK, pleckstrin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    P47
  • Links
    NCBI Gene ID: 5341
    neXtProt AC: NX_P08567

  • Chr Location
    2p13.3; chr2:68365190-68397453 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2000
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PLEK
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Plek
  • Incidental Mutations
Mice homozygous for a null mutation display mild thrombocytopenia, impaired platelet aggregation, and impaired platelet granule secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005189 VEGA Gene Model | MGI Sequence Detail 81176 C57BL/6J ±  kb
transcript OTTMUST00000011599 VEGA | MGI Sequence Detail 4101 Not Applicable  
polypeptide OTTMUSP00000005390 VEGA | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    415 from dbSNP Build 137
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1917248
References
more
  • Summaries
    All 20
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:59221 Cmarik JL, et al., cDNA cloning and mapping of mouse pleckstrin (Plek), a gene upregulated in transformation-resistant cells. Genomics. 2000 Jun 1;66(2):204-12
  • Latest
    J:148429 Lian L, et al., Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood. 2009 Apr 9;113(15):3577-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory