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Plek Gene Detail
Summary
  • Symbol
    Plek
  • Name
    pleckstrin
  • Synonyms
    2010300B13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860485
    NCBI Gene: 56193
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:16971206-17008718 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 9.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860485
protein coding gene Chr11:16971206-17052381 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018054
protein coding gene Chr11:14364503-14402930 (-)
A/J MGP_AJ_G0018027
protein coding gene Chr11:13872825-13910624 (-)
AKR/J MGP_AKRJ_G0017991
protein coding gene Chr11:14367674-14404573 (-)
BALB/cJ MGP_BALBcJ_G0017995
protein coding gene Chr11:13989019-14025991 (-)
C3H/HeJ MGP_C3HHeJ_G0017808
protein coding gene Chr11:14292304-14330656 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018447
protein coding gene Chr11:14969625-15010841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016105
protein coding gene Chr11:13053344-13129241 (-)
CAST/EiJ MGP_CASTEiJ_G0017370
protein coding gene Chr11:14283273-14366582 (-)
CBA/J MGP_CBAJ_G0017783
protein coding gene Chr11:15786743-15826380 (-)
DBA/2J MGP_DBA2J_G0017893
protein coding gene Chr11:13860209-13897053 (-)
FVB/NJ MGP_FVBNJ_G0017885
protein coding gene Chr11:13649227-13686637 (-)
LP/J MGP_LPJ_G0017964
protein coding gene Chr11:14528368-14570602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017911
protein coding gene Chr11:16235111-16273592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018488
protein coding gene Chr11:14450691-14493710 (-)
PWK/PhJ MGP_PWKPhJ_G0017150
protein coding gene Chr11:13837210-13921872 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016947
protein coding gene Chr11:14207985-14291679 (-)
WSB/EiJ MGP_WSBEiJ_G0017424
protein coding gene Chr11:14150915-14185869 (-)



Homology
more
  • Human Ortholog
    PLEK, pleckstrin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLEK, pleckstrin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P47
  • Links
    NCBI Gene ID: 5341
    neXtProt AC: NX_P08567
    UniProt: P08567

  • Chr Location
    2p14; chr2:68365190-68397453 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2000
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLEK
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display mild thrombocytopenia, impaired platelet aggregation, and impaired platelet granule secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56193 NCBI Gene Model | MGI Sequence Detail 37513 C57BL/6J ±  kb
transcript NM_019549 RefSeq | MGI Sequence Detail 4117 C57BL/6  
polypeptide Q9JHK5 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1917248
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory