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Nmu Gene Detail
Summary
  • Symbol
    Nmu
  • Name
    neuromedin U
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860476
    NCBI Gene: 56183
Location & Maps
more
  • Sequence Map
    Chr5:76333495-76363788 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30294 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 40.93 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NMU, neuromedin U
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NMU, neuromedin U
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 10874
    neXtProt AC: NX_P48645

  • Chr Location
    4q12; chr4:55595229-55636698 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Gene trapped
    7
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Nmu
  • Incidental Mutations
Homozygous null mice are healthy and viable.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026473 VEGA Gene Model | MGI Sequence Detail 30294 C57BL/6J ±  kb
transcript OTTMUST00000065456 VEGA | MGI Sequence Detail 828 Not Applicable  
polypeptide OTTMUSP00000032629 VEGA | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    224 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011295 neuromedin-U
  • InterPro Domains
    IPR018070 Neuromedin U, amidation site
    IPR008200 Neuromedin U, C-terminal
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:66232 Wilsbacher LD, et al., The mouse clock locus: sequence and comparative analysis of 204 Kb from mouse chromosome 5. Genome Res. 2000 Dec;10(12):1928-40
  • Latest
    J:219926 Lee IT, et al., Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. Neuron. 2015 Mar 4;85(5):1086-102

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory