Pck2
Gene Detail

Symbol Name ID

Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) MGI:1860456

Synonyms

1810010O14Rik, 9130022B02Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:55540266-55550017 bp, + strand From NCBI annotation of GRCm38   9752 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3356  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphoenolpyruvate carboxykinase (GTP)
Gene Tree: Pck2

Human homologs

Human Homolog		PCK2, phosphoenolpyruvate carboxykinase 2 (mitochondrial)
NCBI Gene ID		5106
neXtProt AC		NX_Q16822
Human Synonyms		PEPCK, PEPCK2, PEPCK-M
Human Chr (Location)		14q11.2; chr14:24563483-24573339 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PCK2

Alleles and phenotypes

All alleles(4) : Targeted(1) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	gluconeogenesis, metabolic process, ...
Component	mitochondrion
Function	carboxy-lyase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (95)    Tissues (95)    Images (15)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	95

cDNA source data(96)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(102) Genomic(6) cDNA(96)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000040618 (Evidence)
Entrez Gene	74551 (Evidence)
UniGene	29856
DFCI	TC1574235, TC1696462
DoTS	DT.101387935, DT.101387937, DT.101387938, DT.110757723, DT.110757736, DT.530387
NIA Mouse Gene Index	U015656
EC	4.1.1.32
Consensus CDS Project	CCDS27114.1
International Mouse Knockout Project Status	Pck2

Sequences

Length	Strain/Species
genomic	74551	NCBI Gene Model | MGI Sequence Detail	9752	C57BL/6J
transcript	NM_028994	RefSeq | MGI Sequence Detail	3400	C57BL/6
polypeptide	Q8BH04	UniProt | EBI | MGI Sequence Detail	640	Not Applicable

All sequences(50) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013035	Phosphoenolpyruvate carboxykinase, C-terminal
InterPro	IPR008209	Phosphoenolpyruvate carboxykinase, GTP-utilising
InterPro	IPR018091	Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
InterPro	IPR008210	Phosphoenolpyruvate carboxykinase, N-terminal
Protein Ontology	PR:000012417	phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Other accession IDs

MGI:1916307, MGI:1921801