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Pck2
Gene Detail
Symbol

Name
ID
Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
MGI:1860456
Synonyms
1810010O14Rik, 9130022B02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:55540266-55550017 bp, + strand
From Ensembl annotation of GRCm38

  9752 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3356  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PCK2
Protein SuperFamily: phosphoenolpyruvate carboxykinase (GTP)
Gene Tree: Pck2

Human
homologs
PCK2, phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5106
neXtProt AC: NX_Q16822

Human Synonyms: PEPCK, PEPCK2, PEPCK-M

Human Chr (Location): 14q11.2; chr14:24094131-24104132 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PCK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Pck2 interacts with 206 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process gluconeogenesis, NADH oxidation, ...
Component extracellular exosome, mitochondrion
Function carboxy-lyase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (95)    Tissues (95)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pck2 ; ZFIN pck2    NEW 
Molecular
reagents
All nucleic(21) Genomic(6) cDNA(15)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000040618 (Evidence)
Entrez Gene 74551 (Evidence)
DFCI TC1696462, TC1574235
DoTS DT.101387938, DT.101387937, DT.101387935, DT.110757736, DT.530387, DT.110757723
NIA Mouse Gene Index U015656
EC 4.1.1.32
Consensus CDS Project CCDS27114.1
International Mouse Phenotyping Consortium Status Pck2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040618 Ensembl Gene Model | MGI Sequence Detail 9752 C57BL/6J ±  kb
transcript ENSMUST00000048781 Ensembl | MGI Sequence Detail 3400 Not Applicable 
polypeptide ENSMUSP00000038555 Ensembl | MGI Sequence Detail 667 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
InterPro IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
InterPro IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
InterPro IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
Protein Ontology PR:000012417 phosphoenolpyruvate carboxykinase [GTP], mitochondrial
References
(Earliest) J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)
Other
accession IDs
MGI:1916307, MGI:1921801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory