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Pck2 Gene Detail
Summary
  • Symbol
    Pck2
  • Name
    phosphoenolpyruvate carboxykinase 2 (mitochondrial)
  • Synonyms
    1810010O14Rik, 9130022B02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860456
    NCBI Gene: 74551
Location & Maps
more
  • Sequence Map
    Chr14:55540266-55550017 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9752 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PCK2, phosphoenolpyruvate carboxykinase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCK2, phosphoenolpyruvate carboxykinase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PEPCK, PEPCK2, PEPCK-M
  • Links
    NCBI Gene ID: 5106
    neXtProt AC: NX_Q16822

  • Chr Location
    14q11.2-q12; chr14:24094131-24104132 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PCK2 associations

Human Disease Mouse Models
       Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial   OMIM: 261650
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    1
  • Genomic Mutations
    1 involving Pck2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040618 Ensembl Gene Model | MGI Sequence Detail 9752 C57BL/6J ±  kb
transcript ENSMUST00000048781 Ensembl | MGI Sequence Detail 3400 Not Applicable  
polypeptide ENSMUSP00000038555 Ensembl | MGI Sequence Detail 667 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • EC
  • InterPro Domains
    IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
    IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
    IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
    IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
Molecular
Reagents
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  • All nucleic 21
    Genomic 6
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
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MGI:1916307, MGI:1921801
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory