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Pck2 Gene Detail
Summary
  • Symbol
    Pck2
  • Name
    phosphoenolpyruvate carboxykinase 2 (mitochondrial)
  • Synonyms
    1810010O14Rik, 9130022B02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860456
    NCBI Gene: 74551
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55540263-55550020 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860456
protein coding gene Chr14:55540263-55551242 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021347
protein coding gene Chr14:49572648-49582392 (+)
A/J MGP_AJ_G0021306
protein coding gene Chr14:48586562-48596071 (+)
AKR/J MGP_AKRJ_G0021282
protein coding gene Chr14:50333188-50342613 (+)
BALB/cJ MGP_BALBcJ_G0021310
protein coding gene Chr14:48532841-48542572 (+)
C3H/HeJ MGP_C3HHeJ_G0021090
protein coding gene Chr14:50018992-50028615 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021748
protein coding gene Chr14:52062669-52075759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019295
protein coding gene Chr14:46962298-46971863 (+)
CAST/EiJ MGP_CASTEiJ_G0020609
protein coding gene Chr14:46280193-46289870 (+)
CBA/J MGP_CBAJ_G0021057
protein coding gene Chr14:53622382-53633255 (+)
DBA/2J MGP_DBA2J_G0021178
protein coding gene Chr14:48311415-48321166 (+)
FVB/NJ MGP_FVBNJ_G0021160
protein coding gene Chr14:47761884-47771332 (+)
LP/J MGP_LPJ_G0021252
protein coding gene Chr14:50619740-50629384 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021184
protein coding gene Chr14:52983793-52993456 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021775
protein coding gene Chr14:49518943-49529656 (+)
PWK/PhJ MGP_PWKPhJ_G0020356
protein coding gene Chr14:44841732-44851781 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020184
protein coding gene Chr14:45515614-45525274 (+)
WSB/EiJ MGP_WSBEiJ_G0020662
protein coding gene Chr14:49800899-49812364 (+)



Homology
more
  • Human Ortholog
    PCK2, phosphoenolpyruvate carboxykinase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCK2, phosphoenolpyruvate carboxykinase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PEPCK, PEPCK2, PEPCK-M
  • Links
    NCBI Gene ID: 5106
    neXtProt AC: NX_Q16822
    UniProt: Q16822

  • Chr Location
    14q11.2-q12; chr14:24094131-24104132 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74551 NCBI Gene Model | MGI Sequence Detail 9758 C57BL/6J ±  kb
    transcript NM_028994 RefSeq | MGI Sequence Detail 3420 C57BL/6  
    polypeptide Q8BH04 UniProt | EBI | MGI Sequence Detail 640 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000012417 phosphoenolpyruvate carboxykinase [GTP], mitochondrial
    • EC
    • InterPro Domains
      IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
      IPR035077 Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain
      IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
      IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
      IPR035078 Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal
      IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 6
      cDNA 16

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916307, MGI:1921801
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
    • Latest
      J:300236 Abulizi A, et al., Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health. Cell Metab. 2020 Nov 3;32(5):751-766.e11

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    04/06/2021
    MGI 6.16
    The Jackson Laboratory