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Phc2 Gene Detail
Summary
  • Symbol
    Phc2
  • Name
    polyhomeotic 2
  • Synonyms
    D130050K19Rik, D4Ertd810e, Edr2, Mph2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860454
    NCBI Gene: 54383
  • Gene Overview
    MyGene.info: PHC2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:128654738-128752881 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      98144 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 62.12 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PHC2, polyhomeotic homolog 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PHC2, polyhomeotic homolog 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDR2, HPH2, PH2
  • Links
    NCBI Gene ID: 1912
    neXtProt AC: NX_Q8IXK0
    UniProt: Q8IXK0

  • Chr Location
    1p35.1; chr1:33323623-33431017 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 2 genetic backgrounds
    29 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have normal skulls but exhibit posterior homeotic transformations of the axial skeleton. Cultured mouse embryonic fibroblasts show defects in proliferation and premature senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009456 VEGA Gene Model | MGI Sequence Detail 98144 C57BL/6J ±  kb
    transcript OTTMUST00000021536 VEGA | MGI Sequence Detail 3885 Not Applicable  
    polypeptide OTTMUSP00000009839 VEGA | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      1034 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1289316, MGI:2140153, MGI:2441942
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 9
      Gene Ontology 14
      Phenotypes 17
    • Earliest
      J:62648 Hemenway CS, et al., The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene. 1998 May 14;16(19):2541-7
    • Latest
      J:204987 Isono K, et al., SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell. 2013 Sep 30;26(6):565-77

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory