About   Help   FAQ
Phc2
Gene Detail
Symbol

Name
ID
Phc2
polyhomeotic-like 2 (Drosophila)
MGI:1860454
Synonyms
D130050K19Rik, D4Ertd810e, Edr2, Mph2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
62.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:128654738-128752881 bp, + strand
From VEGA annotation of GRCm38

  98144 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: PHC2
Gene Tree: Phc2

Human
homologs
PHC2, polyhomeotic homolog 2 (Drosophila)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1912
neXtProt AC: NX_Q8IXK0

Human Synonyms: EDR2, HPH2, PH2

Human Chr (Location): 1p34.3; chr1:33323623-33430610 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(44) Targeted(8)
Genomic Mutations involving Phc2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele have normal skulls but exhibit posterior homeotic transformations of the axial skeleton. Cultured mouse embryonic fibroblasts show defects in proliferation and premature senescence.
 
Interactions
Phc2 interacts with 262 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process multicellular organismal development, spermatogenesis
Component heterochromatin, nucleoplasm, ...
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (79)    Tissues (45)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 71
Northern blot 8
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase phc2 ; ZFIN phc2a    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009456 (Evidence)
Ensembl Gene Model ENSMUSG00000028796 (Evidence)
Entrez Gene 54383 (Evidence)
DFCI TC1572271, TC1588883, TC1595062, TC1609974, TC1655879
DoTS DT.101280799, DT.101736439, DT.110793285, DT.110793289, DT.535130, DT.91376369, DT.91385313, DT.94357506
NIA Mouse Gene Index U004850
Consensus CDS Project CCDS18674.1, CCDS57297.1
International Mouse Phenotyping Consortium Status Phc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009456 VEGA Gene Model | MGI Sequence Detail 98144 C57BL/6J ±  kb
transcript OTTMUST00000021536 VEGA | MGI Sequence Detail 3885 Not Applicable 
polypeptide OTTMUSP00000009839 VEGA | MGI Sequence Detail 850 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(21) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(1044 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR012313 Zinc finger, FCS-type
Protein Ontology PR:000012634 polyhomeotic-like protein 2
References
(Earliest) J:62648 Hemenway CS, et al., The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene. 1998 May 14;16(19):2541-7
(Latest) J:204987 Isono K, et al., SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell. 2013 Sep 30;26(6):565-77
All references(53)
Other
accession IDs
MGI:1289316, MGI:2140153, MGI:2441942

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory