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Phc2 Gene Detail
Summary
  • Symbol
    Phc2
  • Name
    polyhomeotic 2
  • Synonyms
    D130050K19Rik, D4Ertd810e, Edr2, Mph2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860454
    NCBI Gene: 54383
  • Gene Overview
    MyGene.info: PHC2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:128654702-128752881 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 62.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1034 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860454
protein coding gene Chr4:128654673-128752881 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028805
protein coding gene Chr4:130474306-130577585 (+)
A/J MGP_AJ_G0028764
protein coding gene Chr4:125321340-125421274 (+)
AKR/J MGP_AKRJ_G0028717
protein coding gene Chr4:128784379-128887194 (+)
BALB/cJ MGP_BALBcJ_G0028787
protein coding gene Chr4:125898105-125996787 (+)
C3H/HeJ MGP_C3HHeJ_G0028501
protein coding gene Chr4:128840486-128946525 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029229
protein coding gene Chr4:135422898-135537306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026502
protein coding gene Chr4:118452237-118549570 (+)
CAST/EiJ MGP_CASTEiJ_G0027934
protein coding gene Chr4:127005130-127103759 (+)
CBA/J MGP_CBAJ_G0028467
protein coding gene Chr4:138717614-138827382 (+)
DBA/2J MGP_DBA2J_G0028616
protein coding gene Chr4:125750970-125849291 (+)
FVB/NJ MGP_FVBNJ_G0028583
protein coding gene Chr4:124501201-124600953 (+)
LP/J MGP_LPJ_G0028717
protein coding gene Chr4:130790152-130895948 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028609
protein coding gene Chr4:143649751-143753869 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029267
protein coding gene Chr4:129155705-129257268 (+)
PWK/PhJ MGP_PWKPhJ_G0027655
protein coding gene Chr4:122312606-122412949 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027482
protein coding gene Chr4:125003037-125106417 (+)
WSB/EiJ MGP_WSBEiJ_G0028014
protein coding gene Chr4:129259188-129364793 (+)



Homology
more
  • Human Ortholog
    PHC2, polyhomeotic homolog 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PHC2, polyhomeotic homolog 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDR2, HPH2, PH2
  • Links
    NCBI Gene ID: 1912
    neXtProt AC: NX_Q8IXK0
    UniProt: Q8IXK0

  • Chr Location
    1p35.1; chr1:33323623-33431017 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 2 genetic backgrounds
    29 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have normal skulls but exhibit posterior homeotic transformations of the axial skeleton. Cultured mouse embryonic fibroblasts show defects in proliferation and premature senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028796 Ensembl Gene Model | MGI Sequence Detail 98180 C57BL/6J ±  kb
    transcript ENSMUST00000106080 Ensembl | MGI Sequence Detail 3885 Not Applicable  
    polypeptide ENSMUSP00000101690 Ensembl | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1289316, MGI:2140153, MGI:2441942
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 9
      Gene Ontology 14
      Phenotypes 17
    • Earliest
      J:62648 Hemenway CS, et al., The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene. 1998 May 14;16(19):2541-7
    • Latest
      J:204987 Isono K, et al., SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell. 2013 Sep 30;26(6):565-77

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory