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Cldn14 Gene Detail
Summary
  • Symbol
    Cldn14
  • Name
    claudin 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860425
    NCBI Gene: 56173
  • Gene Overview
    MyGene.info: CLDN14
Location & Maps
more
  • Sequence Map
    Chr16:93919032-94008837 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      89806 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 54.99 cM, cytoband C3-4
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CLDN14, claudin 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLDN14, claudin 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB29
  • Links
    NCBI Gene ID: 23562
    neXtProt AC: NX_O95500

  • Chr Location
    21q22.13; chr21:36460621-36580085 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8115
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLDN14
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Cldn14 mouse models; 1 with human CLDN14 associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 29; DFNB29   OMIM: 614035 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    77
  • Gene trapped
    67
  • Targeted
    10
  • Genomic Mutations
    8 involving Cldn14
  • Incidental Mutations
    APF
Homozygous mutant mice have a normal endocochlear potential but are deaf due to cochlear hair cell degeneration within the first 3 weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019962 VEGA Gene Model | MGI Sequence Detail 89806 C57BL/6J ±  kb
transcript OTTMUST00000047562 VEGA | MGI Sequence Detail 1457 Not Applicable  
polypeptide OTTMUSP00000021531 VEGA | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    715 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 9
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146507
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Diseases 4
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:202128 Baker M, et al., Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth. PLoS One. 2013;8(5):e62516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory