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Cldn14 Gene Detail
Summary
  • Symbol
    Cldn14
  • Name
    claudin 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860425
    NCBI Gene: 56173
  • Gene Overview
    MyGene.info: CLDN14
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:93919031-94008837 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 54.99 cM, cytoband C3-4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    715 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860425
protein coding gene Chr16:93919031-94008837 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023066
protein coding gene Chr16:95134379-95222573 (-)
A/J MGP_AJ_G0023034
protein coding gene Chr16:90666793-90753553 (-)
AKR/J MGP_AKRJ_G0023004
protein coding gene Chr16:93447774-93535963 (-)
BALB/cJ MGP_BALBcJ_G0023036
protein coding gene Chr16:91190311-91279015 (-)
C3H/HeJ MGP_C3HHeJ_G0022797
protein coding gene Chr16:93953226-94043978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023483
protein coding gene Chr16:98146263-98239398 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020985
protein coding gene Chr16:88513992-88602415 (-)
CAST/EiJ MGP_CASTEiJ_G0022316
protein coding gene Chr16:94686667-94785470 (-)
CBA/J MGP_CBAJ_G0022766
protein coding gene Chr16:102405348-102504217 (-)
DBA/2J MGP_DBA2J_G0022900
protein coding gene Chr16:90554445-90642352 (-)
FVB/NJ MGP_FVBNJ_G0022874
protein coding gene Chr16:89710301-89800073 (-)
LP/J MGP_LPJ_G0022970
protein coding gene Chr16:94796134-94888899 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022895
protein coding gene Chr16:106777391-106874203 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023501
protein coding gene Chr16:93949330-94041919 (-)
PWK/PhJ MGP_PWKPhJ_G0022061
protein coding gene Chr16:90805328-90896129 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021891
protein coding gene Chr16:93488177-93581970 (-)
WSB/EiJ MGP_WSBEiJ_G0022367
protein coding gene Chr16:94200430-94291948 (-)



Homology
more
  • Human Ortholog
    CLDN14, claudin 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLDN14, claudin 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB29
  • Links
    NCBI Gene ID: 23562
    neXtProt AC: NX_O95500
    UniProt: O95500

  • Chr Location
    21q22.13; chr21:36460621-36576569 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8115
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLDN14
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Cldn14 mouse models; 1 with human CLDN14 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice have a normal endocochlear potential but are deaf due to cochlear hair cell degeneration within the first 3 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56173 NCBI Gene Model | MGI Sequence Detail 89807 C57BL/6J ±  kb
transcript NM_019500 RefSeq | MGI Sequence Detail 1475 C57BL/6  
polypeptide Q9Z0S3 UniProt | EBI | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 10
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146507
References
more
  • Summaries
    All 64
    Developmental Gene Expression 4
    Diseases 4
    Gene Ontology 4
    Phenotypes 32
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory