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Cldn14
Gene Detail
Symbol

Name
ID
Cldn14
claudin 14
MGI:1860425
Feature Type
protein coding gene
Genetic Map
Chromosome 16
54.99 cM, cytoband C3-4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:93919032-94008837 bp, - strand
From VEGA annotation of GRCm38

  89806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cldn14

Human
homologs
Human Homolog CLDN14, claudin 14
NCBI Gene ID 23562
neXtProt AC  NX_O95500
Human Synonyms  DFNB29
Human Chr (Location)  21q22.3; chr21:36460621-36576569 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CLDN14
Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Gene trapped(67) Targeted(4)
Genomic Mutations involving Cldn14 (2)
Incidental mutations (data from APF )
 
Homozygous mutant mice have a normal endocochlear potential but are deaf due to cochlear hair cell degeneration within the first 3 weeks of age.
 
Human Diseases Modeled Using Mouse Cldn14 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cldn14 interacts with 45 markers (Mir1b, Mir130b, Mir133a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Component cell junction, endoplasmic reticulum, ...
Function protein binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (67)    Tissues (66)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
RT-PCR 18
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(9) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019962 (Evidence)
Ensembl Gene ModelENSMUSG00000047109 (Evidence)
Entrez Gene56173 (Evidence)
UniGene328716
DFCITC1588503, TC1656216
DoTSDT.50315240, DT.91336098
NIA Mouse Gene IndexU037325
Consensus CDS ProjectCCDS28345.1
International Mouse Knockout Project StatusCldn14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019962 VEGA Gene Model | MGI Sequence Detail 89806 C57BL/6J ±  kb
transcript OTTMUST00000047562 VEGA | MGI Sequence Detail 1457 Not Applicable 
polypeptide OTTMUSP00000021531 VEGA | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(777 from dbSNP Build 137)    SNPs within 2kb including multiple locations(781)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003556 Claudin-14
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005541 claudin-14
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202128 Baker M, et al., Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth. PLoS One. 2013;8(5):e62516
All references(43)
Disease annotation references (1)
Other
accession IDs
MGI:2146507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory