Nagk MGI Mouse Gene Detail - MGI:1860418 - N-acetylglucosamine kinase

Symbol

Nagk
Name

N-acetylglucosamine kinase
Synonyms

GlcNAc kinase

Feature Type

protein coding gene
IDs

MGI:1860418
NCBI Gene: 56174
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:83770810-83779538 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.96 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

475 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860418	protein coding gene	Chr6:83770810-83781000 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030941	protein coding gene	Chr6:84830902-84839932 (+)
A/J	MGP_AJ_G0030910	protein coding gene	Chr6:81600286-81609332 (+)
AKR/J	MGP_AKRJ_G0030838	protein coding gene	Chr6:83961072-83970140 (+)
BALB/cJ	MGP_BALBcJ_G0030920	protein coding gene	Chr6:81628359-81637400 (+)
C3H/HeJ	MGP_C3HHeJ_G0030790	protein coding gene	Chr6:100438745-100447786 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031380	protein coding gene	Chr6:87176561-87185592 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028566	protein coding gene	Chr6:79964510-79973493 (+)
CAST/EiJ	MGP_CASTEiJ_G0030029	protein coding gene	Chr6:83988783-83997846 (+)
CBA/J	MGP_CBAJ_G0030607	protein coding gene	Chr6:90595624-90604671 (+)
DBA/2J	MGP_DBA2J_G0030760	protein coding gene	Chr6:80913396-80922412 (+)
FVB/NJ	MGP_FVBNJ_G0030713	protein coding gene	Chr6:80125653-80134699 (+)
LP/J	MGP_LPJ_G0030839	protein coding gene	Chr6:84834787-84843822 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030749	protein coding gene	Chr6:94858917-94867959 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031404	protein coding gene	Chr6:83792038-83801109 (+)
PWK/PhJ	MGP_PWKPhJ_G0029744	protein coding gene	Chr6:79830414-79839527 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029572	protein coding gene	Chr6:82615034-82624076 (+)
WSB/EiJ	MGP_WSBEiJ_G0030110	protein coding gene	Chr6:84209501-84218540 (+)

Human Ortholog

NAGK, N-acetylglucosamine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAGK, N-acetylglucosamine kinase
Synonyms

GNK, HSA242910
Links

HGNC:17174

NCBI Gene ID: 55577

UniProt: Q9UJ70
Chr Location

2p13.3; chr2:71064344-71079808 (+) GRCh38

MGI Vertebrate Homology

Nagk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAGK
Gene Tree

Nagk

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

3
Gene trapped

2
Spontaneous

1
Targeted

7
Genomic Mutations

2 involving Nagk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

A gene trap insertion into an intron of this gene results in no obvious phenotype.

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All GO Annotations

46
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

118
cDNA Data

5
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nagk

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All Sequences

82
RefSeq

34
UniProt

4
CCDS

CCDS20286.1, CCDS85072.1

Ensembl

ENSMUSG00000034744 (Evidence)
NCBI Gene

56174

			Length	Strain/Species	Flank
genomic	56174	NCBI Gene Model \| MGI Sequence Detail	8729	C57BL/6J	± kb
transcript	NM_001411290	RefSeq \| MGI Sequence Detail	1563	C57BL/6
polypeptide	Q9QZ08	UniProt \| EBI \| MGI Sequence Detail	343	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010960 N-acetyl-D-glucosamine kinase

(term hierarchy)
EC

2.7.1.-, 2.7.1.59, 2.7.1.60
InterPro Domains

IPR002731 ATPase, BadF/BadG/BcrA/BcrD type

IPR043129 ATPase, nucleotide binding domain

IPR039758 N-acetyl-D-glucosamine kinase NAGK-like

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All nucleic 10

cDNA 8

Primer pair 1

Other 1

Microarray probesets 6

Summaries

All 53

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 21
Earliest

J:62543 Hinderlich S, et al., Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem. 2000 Jun;267(11):3301-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nagk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57376	Chr6:83771956-83771967 (+)	1,152 bp
Tssr57377	Chr6:83771984-83771997 (+)	1,181 bp
Tssr57378	Chr6:83772004-83772016 (+)	1,200 bp
Tssr57379	Chr6:83772140-83772151 (+)	1,336 bp
Tssr57380	Chr6:83772164-83772186 (+)	1,365 bp
Tssr57381	Chr6:83772187-83772220 (+)	1,394 bp
Tssr57382	Chr6:83772228-83772237 (+)	1,423 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24