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Nagk Gene Detail
Summary
  • Symbol
    Nagk
  • Name
    N-acetylglucosamine kinase
  • Synonyms
    GlcNAc kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860418
    NCBI Gene: 56174
  • Gene Overview
    MyGene.info: NAGK
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr6:83794982-83804018 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9037 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.96 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NAGK, N-acetylglucosamine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NAGK, N-acetylglucosamine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GNK, HSA242910
  • Links
    NCBI Gene ID: 55577
    neXtProt AC: NX_Q9UJ70
    UniProt: Q9UJ70

  • Chr Location
    2p13.3; chr2:71068246-71078868 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9720
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NAGK
  • Gene Tree
    Nagk
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A gene trap insertion into an intron of this gene results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    135
  • Tissues
    117
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023757 VEGA Gene Model | MGI Sequence Detail 9037 C57BL/6J ±  kb
    transcript OTTMUST00000058044 VEGA | MGI Sequence Detail 1323 Not Applicable  
    polypeptide OTTMUSP00000028071 VEGA | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      68 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:62543 Hinderlich S, et al., Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem. 2000 Jun;267(11):3301-8
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory