Nagk
Gene Detail

Symbol Name ID

Nagk N-acetylglucosamine kinase MGI:1860418

Synonyms

GlcNAc kinase

Feature Type

protein coding gene

Genetic Map

Chromosome 6

35.96 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:83794982-83803420 bp, + strand From VEGA annotation of GRCm38   8439 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9720  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Nagk

Human homologs

Human Homolog		NAGK, N-acetylglucosamine kinase
NCBI Gene ID		55577
neXtProt AC		NX_Q9UJ70
Human Synonyms		GNK, HSA242910
Human Chr (Location)		2p13.3; chr2:71068277-71078868 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

A gene trap insertion into an intron of this gene results in no obvious phenotype.

 

Interactions

Nagk interacts with 141 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	carbohydrate phosphorylation, N-acetylglucosamine metabolic process, ...
Component	extracellular vesicular exosome
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (106)    Tissues (106)    Images (4)
Theiler Stages: 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	94
Northern blot	12

cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(8) cDNA(7) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000023757 (Evidence)
Ensembl Gene Model	ENSMUSG00000034744 (Evidence)
Entrez Gene	56174 (Evidence)
DFCI	TC1580187, TC1611040, TC1616381, TC1681289
NIA Mouse Gene Index	U007088
EC	2.7.1.59
Consensus CDS Project	CCDS20286.1
International Mouse Knockout Project Status	Nagk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023757	VEGA Gene Model | MGI Sequence Detail	8439	C57BL/6J
transcript	OTTMUST00000058044	VEGA | MGI Sequence Detail	1323	Not Applicable
polypeptide	OTTMUSP00000028071	VEGA | MGI Sequence Detail	361	Not Applicable

All sequences(61) RefSeq(18) UniProt(4)

Polymorphisms

SNPs within 2kb(66 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002731	ATPase, BadF/BadG/BcrA/BcrD type
Protein Ontology	PR:000010960	N-acetyl-D-glucosamine kinase

References

(Earliest) J:62543 Hinderlich S, et al., Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem. 2000 Jun;267(11):3301-8
(Latest) J:188842 Bergfeld AK, et al., Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. J Biol Chem. 2012 Aug 17;287(34):28865-81
All references(34)