Nagk MGI Mouse Gene Detail - MGI:1860418 - N-acetylglucosamine kinase

Nagk Gene Detail

Symbol

Nagk
Name

N-acetylglucosamine kinase
Synonyms

GlcNAc kinase

Feature Type

protein coding gene
IDs

MGI:1860418
NCBI Gene: 56174
Gene Overview

MyGene.info: NAGK

Sequence Map

Chr6:83794982-83804018 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

9037 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.96 cM, cytoband D1
Mapping Data

2 experiments

Human Ortholog

NAGK, N-acetylglucosamine kinase

Vertebrate Orthologs

9

Human Ortholog

NAGK, N-acetylglucosamine kinase
Orthology source: HomoloGene, HGNC
Synonyms

GNK, HSA242910
Links

HGNC:17174

NCBI Gene ID: 55577

neXtProt AC: NX_Q9UJ70

UniProt: Q9UJ70
Chr Location

2p13.3; chr2:71068246-71078868 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9720
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NAGK
Gene Tree

Nagk

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

2
Spontaneous

1
Targeted

7
Genomic Mutations

1 involving Nagk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

A gene trap insertion into an intron of this gene results in no obvious phenotype.

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All GO Annotations

11
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

135
Tissues

117
cDNA Data

4
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nagk

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Nagk interacts with 141 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

60
RefSeq

16
UniProt

4
CCDS

CCDS20286.1, CCDS85072.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023757	VEGA Gene Model \| MGI Sequence Detail	9037	C57BL/6J	± kb
transcript	OTTMUST00000058044	VEGA \| MGI Sequence Detail	1323	Not Applicable
polypeptide	OTTMUSP00000028071	VEGA \| MGI Sequence Detail	361	Not Applicable

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SNPs within 2kb

68 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000010960 N-acetyl-D-glucosamine kinase

(term hierarchy)
EC

2.7.1.59
InterPro Domains

IPR002731 ATPase, BadF/BadG/BcrA/BcrD type

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All nucleic 8

cDNA 7

Other 1

Microarray probesets 6

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 14
Earliest

J:62543 Hinderlich S, et al., Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem. 2000 Jun;267(11):3301-8
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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