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Nagk Gene Detail
Summary
  • Symbol
    Nagk
  • Name
    N-acetylglucosamine kinase
  • Synonyms
    GlcNAc kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860418
    NCBI Gene: 56174
  • Gene Overview
    MyGene.info: NAGK
Location & Maps
more
  • Sequence Map
    Chr6:83794982-83804018 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9037 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.96 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NAGK, N-acetylglucosamine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NAGK, N-acetylglucosamine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GNK, HSA242910
  • Links
    NCBI Gene ID: 55577
    neXtProt AC: NX_Q9UJ70

  • Chr Location
    2p13.3; chr2:71068241-71078868 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 9720
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NAGK
  • Gene Tree
    Nagk
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    2
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Nagk
  • Incidental Mutations
    Mutagenetix , APF
A gene trap insertion into an intron of this gene results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    135
  • Tissues
    116
  • cDNA Data
    4
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023757 VEGA Gene Model | MGI Sequence Detail 9037 C57BL/6J ±  kb
transcript OTTMUST00000058044 VEGA | MGI Sequence Detail 1323 Not Applicable  
polypeptide OTTMUSP00000028071 VEGA | MGI Sequence Detail 361 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010960 N-acetyl-D-glucosamine kinase
  • EC
    2.7.1.59
  • InterPro Domains
    IPR002731 ATPase, BadF/BadG/BcrA/BcrD type
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:62543 Hinderlich S, et al., Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem. 2000 Jun;267(11):3301-8
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory