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Mad2l1
Gene Detail
 Symbol
Name
ID
Mad2l1
MAD2 mitotic arrest deficient-like 1
MGI:1860374
Synonyms MAD2
Feature Type protein coding gene
Genetic Map
Chromosome 6
30.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:66535390-66541033 bp, + strand
From VEGA annotation of GRCm38

  5644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1768  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mitotic spindle assembly checkpoint protein MAD2A
Gene Tree: Mad2l1

Human
homologs
Human Homolog MAD2L1, MAD2 mitotic arrest deficient-like 1 (yeast)
NCBI Gene ID 4085
neXtProt AC  NX_Q13257
Human Synonyms  HSMAD2, MAD2
Human Chr (Location)  4q27; chr4:120059422-120066858 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die at E6.5-7.5. At E5.5, embryonic cells assemble spindles and undergo mitosis but do not arrest in response to microtubule depolymerization. At E6.5, loss of a functional spindle assembly ckeckpoint results in widespread chromosome missegregation and apoptosis.
 
Interactions
Mad2l1 interacts with 161 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell cycle, cell division, ...
Component chromosome, chromosome, centromeric region, ...
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (45)    Tissues (45)    Images (5)
Theiler Stages: 17, 21, 22, 23, 28
Assay TypeResults
RNA in situ 45
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) cDNA(78) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023406 (Evidence)
Ensembl Gene ModelENSMUSG00000029910 (Evidence)
Entrez Gene56150 (Evidence)
UniGene489653
DFCITC1575909, TC1589115, TC1600819
DoTSDT.493327, DT.94404554, DT.99849585
NIA Mouse Gene IndexU006972
Consensus CDS ProjectCCDS20210.1
International Mouse Knockout Project StatusMad2l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023406 VEGA Gene Model | MGI Sequence Detail 5644 C57BL/6J ±  kb
transcript OTTMUST00000056850 VEGA | MGI Sequence Detail 1370 Not Applicable 
polypeptide OTTMUSP00000027373 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003511 DNA-binding HORMA
InterPro IPR027097 Mitotic spindle checkpoint protein Mad2
Protein Ontology PR:000010038 mitotic spindle assembly checkpoint protein MAD2A
References (Earliest) J:62829 Dobles M, et al., Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 2000 Jun 9;101(6):635-45
(Latest) J:203235 Janssen A, et al., Genetic instability: tipping the balance. Oncogene. 2013 Sep 19;32(38):4459-70
All references(71)
Other
accession IDs
MGI:2144039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory