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Mad2l1
Gene Detail
Symbol

Name
ID
Mad2l1
MAD2 mitotic arrest deficient-like 1
MGI:1860374
Synonyms
MAD2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
30.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:66535390-66541033 bp, + strand
From VEGA annotation of GRCm38

  5644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1768  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAD2L1
Protein SuperFamily: mitotic spindle assembly checkpoint protein MAD2A
Gene Tree: Mad2l1

Human
homologs
MAD2L1, MAD2 mitotic arrest deficient-like 1 (yeast)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4085
neXtProt AC: NX_Q13257

Human Synonyms: HSMAD2, MAD2

Human Chr (Location): 4q27; chr4:120059422-120066858 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die at E6.5-7.5. At E5.5, embryonic cells assemble spindles and undergo mitosis but do not arrest in response to microtubule depolymerization. At E6.5, loss of a functional spindle assembly ckeckpoint results in widespread chromosome missegregation and apoptosis.
 
Interactions
Mad2l1 interacts with 161 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell cycle, cell division, ...
Component chromosome, chromosome, centromeric region, ...
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (45)    Tissues (45)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mad2l1    NEW 
Molecular
reagents
All nucleic(79) cDNA(78) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023406 (Evidence)
Ensembl Gene Model ENSMUSG00000029910 (Evidence)
Entrez Gene 56150 (Evidence)
UniGene 489653
DFCI TC1589115, TC1575909, TC1600819
DoTS DT.99849585, DT.493327, DT.94404554
NIA Mouse Gene Index U006972
Consensus CDS Project CCDS20210.1
International Mouse Phenotyping Consortium Status Mad2l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023406 VEGA Gene Model | MGI Sequence Detail 5644 C57BL/6J ±  kb
transcript OTTMUST00000056850 VEGA | MGI Sequence Detail 1370 Not Applicable 
polypeptide OTTMUSP00000027373 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003511 DNA-binding HORMA
InterPro IPR027097 Mitotic spindle checkpoint protein Mad2
Protein Ontology PR:000010038 mitotic spindle assembly checkpoint protein MAD2A
References
(Earliest) J:62829 Dobles M, et al., Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 2000 Jun 9;101(6):635-45
(Latest) J:208632 Bazzi H, et al., Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1491-500
All references(70)
Other
accession IDs
MGI:2144039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory