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Grasp
Gene Detail
Symbol

Name
ID
Grasp
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
MGI:1860303
Synonyms
tamalin
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.57 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:101224207-101232755 bp, + strand
From Ensembl annotation of GRCm38

  8549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

Gene Tree: Grasp

Human
homologs
Human Homolog GRASP, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
NCBI Gene ID 160622
neXtProt AC  NX_Q7Z6J2
Human Synonyms  TAMALIN
Human Chr (Location)  12q13.13; chr12:52006945-52015889 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Radiation induced(1) Targeted(3)
Genomic Mutations involving Grasp (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted null mutations develop and behave normally under ordinary conditions but display a marked reduction in sensitivity to acute morphine responses and impaired adaptive responses to morphine and cocaine.
 
Interactions
Grasp interacts with 128 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process intracellular protein transport, protein localization, ...
Component cytoplasm, membrane, ...
Function ADP-ribosylation factor binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(8)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000000531 (Evidence)
Entrez Gene56149 (Evidence)
UniGene276573
DFCITC1593958, TC1582426
DoTSDT.521639
Consensus CDS ProjectCCDS27847.1
International Mouse Knockout Project StatusGrasp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000531 Ensembl Gene Model | MGI Sequence Detail 8549 C57BL/6J ±  kb
transcript ENSMUST00000000543 Ensembl | MGI Sequence Detail 2013 Not Applicable 
polypeptide ENSMUSP00000000543 Ensembl | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
Protein Ontology PR:000008221 general receptor for phosphoinositides 1-associated scaffold protein
References
(Earliest) J:62592 Nevrivy DJ, et al., Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. J Biol Chem. 2000 Jun 2;275(22):16827-36
(Latest) J:181614 Yanpallewar SU, et al., Tamalin is a critical mediator of electroconvulsive shock-induced adult neuroplasticity. J Neurosci. 2012 Feb 15;32(7):2252-62
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory