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Grasp Gene Detail
Summary
  • Symbol
    Grasp
  • Name
    GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
  • Synonyms
    tamalin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860303
    NCBI Gene: 56149
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101224207-101232756 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.57 cM, cytoband F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860303
protein coding gene Chr15:101224188-101232756 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022367
protein coding gene Chr15:103272613-103280968 (+)
A/J MGP_AJ_G0022329
protein coding gene Chr15:99187347-99195730 (+)
AKR/J MGP_AKRJ_G0022305
protein coding gene Chr15:102209430-102217754 (+)
BALB/cJ MGP_BALBcJ_G0022333
protein coding gene Chr15:99289641-99298026 (+)
C3H/HeJ MGP_C3HHeJ_G0022103
protein coding gene Chr15:102296389-102304716 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022781
protein coding gene Chr15:107114413-107122875 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020306
protein coding gene Chr15:94923049-94931384 (+)
CAST/EiJ MGP_CASTEiJ_G0021628
protein coding gene Chr15:103147663-103157296 (+)
CBA/J MGP_CBAJ_G0022072
protein coding gene Chr15:110826772-110838349 (+)
DBA/2J MGP_DBA2J_G0022199
protein coding gene Chr15:98519696-98528076 (+)
FVB/NJ MGP_FVBNJ_G0022178
protein coding gene Chr15:97568925-97577281 (+)
LP/J MGP_LPJ_G0022270
protein coding gene Chr15:103411064-103421109 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022199
protein coding gene Chr15:114520875-114529201 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022795
protein coding gene Chr15:102234818-102245282 (+)
PWK/PhJ MGP_PWKPhJ_G0021367
protein coding gene Chr15:98675027-98683370 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021199
protein coding gene Chr15:102130429-102140529 (+)
WSB/EiJ MGP_WSBEiJ_G0021678
protein coding gene Chr15:102858250-102866525 (+)



Homology
more
  • Human Ortholog
    GRASP, general receptor for phosphoinositides 1 associated scaffold protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GRASP, general receptor for phosphoinositides 1 associated scaffold protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TAMALIN
  • Links
    NCBI Gene ID: 160622
    neXtProt AC: NX_Q7Z6J2
    UniProt: Q7Z6J2

  • Chr Location
    12q13.13; chr12:52006945-52015889 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations develop and behave normally under ordinary conditions but display a marked reduction in sensitivity to acute morphine responses and impaired adaptive responses to morphine and cocaine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56149 NCBI Gene Model | MGI Sequence Detail 8550 C57BL/6J ±  kb
transcript NM_019518 RefSeq | MGI Sequence Detail 2025 Not Specified  
polypeptide Q9JJA9 UniProt | EBI | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 25
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:256043 Chiu SL, et al., GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron. 2017 Mar 22;93(6):1405-1419.e8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory