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Sfrp5 Gene Detail
Summary
  • Symbol
    Sfrp5
  • Name
    secreted frizzled-related sequence protein 5
  • Synonyms
    SARP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860298
    NCBI Gene: 54612
  • Gene Overview
    MyGene.info: SFRP5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:42197971-42202252 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 35.93 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860298
protein coding gene Chr19:42197971-42202252 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025143
protein coding gene Chr19:41525858-41530141 (-)
A/J MGP_AJ_G0025120
protein coding gene Chr19:39527113-39531391 (-)
AKR/J MGP_AKRJ_G0025088
protein coding gene Chr19:40816723-40821011 (-)
BALB/cJ MGP_BALBcJ_G0025114
protein coding gene Chr19:39591782-39596056 (-)
C3H/HeJ MGP_C3HHeJ_G0024874
protein coding gene Chr19:40970837-40975072 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025557
protein coding gene Chr19:42585758-42590050 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022971
protein coding gene Chr19:38883638-38887908 (-)
CAST/EiJ MGP_CASTEiJ_G0024339
protein coding gene Chr19:40652740-40658102 (-)
CBA/J MGP_CBAJ_G0024854
protein coding gene Chr19:44667195-44671483 (-)
DBA/2J MGP_DBA2J_G0024986
protein coding gene Chr19:39373159-39377467 (-)
FVB/NJ MGP_FVBNJ_G0024947
protein coding gene Chr19:39148648-39152952 (-)
LP/J MGP_LPJ_G0025072
protein coding gene Chr19:41508823-41513128 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024978
protein coding gene Chr19:44292742-44297021 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025615
protein coding gene Chr19:40867968-40872251 (-)
PWK/PhJ MGP_PWKPhJ_G0024088
protein coding gene Chr19:39265545-39270053 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023892
protein coding gene Chr19:39611841-39616114 (-)
WSB/EiJ MGP_WSBEiJ_G0024409
protein coding gene Chr19:41016292-41020604 (-)



Homology
more
  • Human Ortholog
    SFRP5, secreted frizzled related protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SFRP5, secreted frizzled related protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SARP3
  • Links
    NCBI Gene ID: 6425
    neXtProt AC: NX_Q5T4F7
    UniProt: Q5T4F7

  • Chr Location
    10q24.2; chr10:97766751-97771999 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    14 phenotype references
Mice homozygous for a null mutation are viable and fertile with no developmental abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54612 NCBI Gene Model | MGI Sequence Detail 4282 C57BL/6J ±  kb
transcript NM_018780 RefSeq | MGI Sequence Detail 1900 C57BL/6  
polypeptide Q9WU66 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR036790 Frizzled cysteine-rich domain superfamily
    IPR020067 Frizzled domain
    IPR015526 Frizzled/secreted frizzled-related protein
    IPR001134 Netrin domain
    IPR018933 Netrin module, non-TIMP type
    IPR034860 Secreted frizzled-related protein 5
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Molecular
Reagents
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  • All nucleic 13
    cDNA 7
    Primer pair 4
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGI:2147584
References
more
  • Summaries
    All 68
    Developmental Gene Expression 36
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:62989 Chang JT, et al., Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. Hum Mol Genet. 1999 Apr;8(4):575-83
  • Latest
    J:260403 Sanz-Navarro M, et al., Plasticity within the niche ensures the maintenance of a Sox2(+) stem cell population in the mouse incisor. Development. 2018 Jan 8;145(1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory