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Sfrp5
Gene Detail
 Symbol
Name
ID
Sfrp5
secreted frizzled-related sequence protein 5
MGI:1860298
Synonyms SARP3
Feature Type protein coding gene
Genetic Map
Chromosome 19
35.93 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:42197971-42202252 bp, - strand
From VEGA annotation of GRCm38

  4282 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2268  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: secreted frizzled-related protein
Gene Tree: Sfrp5

Human
homologs
Human Homolog SFRP5, secreted frizzled-related protein 5
NCBI Gene ID 6425
neXtProt AC  NX_Q5T4F7
Human Synonyms  SARP3
Human Chr (Location)  10q24.1; chr10:97766751-97771999 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(4)
 
Mice homozygous for a null mutation are viable and fertile with no developmental abnormalities.
 
Interactions
Sfrp5 interacts with 89 markers (Mir30c-1, Mir30c-2, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process brain development, canonical Wnt signaling pathway, ...
Component cytoplasm, extracellular region, ...
Function PDZ domain binding, Wnt-activated receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (231)    Tissues (189)    Images (29)
Theiler Stages: 2, 3, 4, 8, 9, 10, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 184
RT-PCR 47
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(5) Primer pair(4) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000021181 (Evidence)
Ensembl Gene ModelENSMUSG00000018822 (Evidence)
Entrez Gene54612 (Evidence)
DFCITC1584667
NIA Mouse Gene IndexU039049
Consensus CDS ProjectCCDS29826.1
International Mouse Knockout Project StatusSfrp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021181 VEGA Gene Model | MGI Sequence Detail 4282 C57BL/6J ±  kb
transcript OTTMUST00000050175 VEGA | MGI Sequence Detail 1900 Not Applicable 
polypeptide OTTMUSP00000023386 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000014747 secreted frizzled-related protein 5
References (Earliest) J:62989 Chang JT, et al., Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. Hum Mol Genet. 1999 Apr;8(4):575-83
(Latest) J:207050 Zhao X, et al., Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Neuroscience. 2013 Jul 1;248C:594-601
All references(58)
Other
accession IDs
MGI:2147584

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory