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Sfrp5 Gene Detail
Summary
  • Symbol
    Sfrp5
  • Name
    secreted frizzled-related sequence protein 5
  • Synonyms
    SARP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860298
    NCBI Gene: 54612
  • Gene Overview
    MyGene.info: SFRP5
Location & Maps
more
  • Sequence Map
    Chr19:42197971-42202252 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4282 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 35.93 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SFRP5, secreted frizzled related protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SFRP5, secreted frizzled related protein 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SARP3
  • Links
    NCBI Gene ID: 6425
    neXtProt AC: NX_Q5T4F7

  • Chr Location
    10q24.1; chr10:97766751-97771999 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    13 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Targeted
    4
Mice homozygous for a null mutation are viable and fertile with no developmental abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021181 VEGA Gene Model | MGI Sequence Detail 4282 C57BL/6J ±  kb
transcript OTTMUST00000050175 VEGA | MGI Sequence Detail 1900 Not Applicable  
polypeptide OTTMUSP00000023386 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR020067 Frizzled domain
    IPR015526 Frizzled/secreted frizzled-related protein
    IPR001134 Netrin domain
    IPR018933 Netrin module, non-TIMP type
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Molecular
Reagents
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  • All nucleic 10
    cDNA 5
    Primer pair 4
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGI:2147584
References
more
  • Summaries
    All 57
    Developmental Gene Expression 28
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:62989 Chang JT, et al., Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. Hum Mol Genet. 1999 Apr;8(4):575-83
  • Latest
    J:230042 Nakamura K, et al., Secreted Frizzled-related Protein 5 Diminishes Cardiac Inflammation and Protects the Heart from Ischemia/Reperfusion Injury. J Biol Chem. 2016 Feb 5;291(6):2566-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory