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Apba1 Gene Detail
Summary
  • Symbol
    Apba1
  • Name
    amyloid beta (A4) precursor protein binding, family A, member 1
  • Synonyms
    6430513E09Rik, Lin-10, Mint, Mint1, X11, X11alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860297
    NCBI Gene: 319924
  • Gene Overview
    MyGene.info: APBA1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:23758876-23949597 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 18.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2579 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860297
protein coding gene Chr19:23758806-23949598 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024990
protein coding gene Chr19:21934072-22133559 (+)
A/J MGP_AJ_G0024967
protein coding gene Chr19:20733084-20925417 (+)
AKR/J MGP_AKRJ_G0024937
protein coding gene Chr19:21532352-21727886 (+)
BALB/cJ MGP_BALBcJ_G0024966
protein coding gene Chr19:20771386-20966202 (+)
C3H/HeJ MGP_C3HHeJ_G0024723
protein coding gene Chr19:21477167-21675909 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025407
protein coding gene Chr19:22626416-22832552 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022826
protein coding gene Chr19:20911732-21104073 (+)
CAST/EiJ MGP_CASTEiJ_G0024192
protein coding gene Chr19:21214939-21415465 (+)
CBA/J MGP_CBAJ_G0024701
protein coding gene Chr19:23609242-23833475 (+)
DBA/2J MGP_DBA2J_G0024833
protein coding gene Chr19:20739846-20934179 (+)
FVB/NJ MGP_FVBNJ_G0024794
protein coding gene Chr19:20602075-20798389 (+)
LP/J MGP_LPJ_G0024917
protein coding gene Chr19:21879912-22084574 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024821
protein coding gene Chr19:23673451-23878726 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025462
protein coding gene Chr19:21514467-21722570 (+)
PWK/PhJ MGP_PWKPhJ_G0023940
protein coding gene Chr19:20331635-20531115 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023745
protein coding gene Chr19:20745406-20976432 (+)
WSB/EiJ MGP_WSBEiJ_G0024259
protein coding gene Chr19:21548878-21745982 (+)



Homology
more
  • Human Ortholog
    APBA1, amyloid beta precursor protein binding family A member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    APBA1, amyloid beta precursor protein binding family A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA
  • Links
    NCBI Gene ID: 320
    neXtProt AC: NX_Q02410
    UniProt: Q02410

  • Chr Location
    9q21.12; chr9:69427532-69673012 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals carrying a homozygous mutation of this gene have reduced body size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024897 Ensembl Gene Model | MGI Sequence Detail 190722 C57BL/6J ±  kb
    transcript ENSMUST00000025830 Ensembl | MGI Sequence Detail 6632 Not Applicable  
    polypeptide ENSMUSP00000025830 Ensembl | MGI Sequence Detail 842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442991
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 9
    • Earliest
      J:62652 Borg JP, et al., Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem. 1998 Nov 27;273(48):31633-6
    • Latest
      J:235509 Motodate R, et al., Expression and localization of X11 family proteins in neurons. Brain Res. 2016 Sep 1;1646:227-34

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory