Ftsj3 MGI Mouse Gene Detail - MGI:1860295 - FtsJ RNA 2'-O-methyltransferase 3

Symbol

Ftsj3
Name

FtsJ RNA 2'-O-methyltransferase 3
Synonyms

C79843, D11Ertd400e, Epcs3

Feature Type

protein coding gene
IDs

MGI:1860295
NCBI Gene: 56095
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:106139968-106146905 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.89 cM
Mapping Data

3 experiments

SNPs within 2kb

42 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860295	protein coding gene	Chr11:106139964-106146910 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019299	protein coding gene	Chr11:109538054-109544991 (-)
A/J	MGP_AJ_G0019267	protein coding gene	Chr11:104876108-104883045 (-)
AKR/J	MGP_AKRJ_G0019236	protein coding gene	Chr11:108003348-108010285 (-)
BALB/cJ	MGP_BALBcJ_G0019241	protein coding gene	Chr11:105276840-105283777 (-)
C3H/HeJ	MGP_C3HHeJ_G0019050	protein coding gene	Chr11:108292866-108299803 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019691	protein coding gene	Chr11:112888644-112895581 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017315	protein coding gene	Chr11:102153837-102160691 (-)
CAST/EiJ	MGP_CASTEiJ_G0018603	protein coding gene	Chr11:109348548-109355533 (-)
CBA/J	MGP_CBAJ_G0019019	protein coding gene	Chr11:117588347-117595284 (-)
DBA/2J	MGP_DBA2J_G0019131	protein coding gene	Chr11:104343938-104350875 (-)
FVB/NJ	MGP_FVBNJ_G0019122	protein coding gene	Chr11:103845305-103852242 (-)
LP/J	MGP_LPJ_G0019201	protein coding gene	Chr11:109977495-109984432 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019152	protein coding gene	Chr11:116871850-116878787 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019728	protein coding gene	Chr11:108495834-108502771 (-)
PWK/PhJ	MGP_PWKPhJ_G0018368	protein coding gene	Chr11:105440944-105447877 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018159	protein coding gene	Chr11:108258967-108265863 (-)
WSB/EiJ	MGP_WSBEiJ_G0018654	protein coding gene	Chr11:108458819-108465756 (-)

Human Ortholog

FTSJ3, FtsJ RNA 2'-O-methyltransferase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FTSJ3, FtsJ RNA 2'-O-methyltransferase 3
Synonyms

EPCS3, SPB1
Links

HGNC:17136

NCBI Gene ID: 117246

neXtProt AC: NX_Q8IY81

UniProt: Q8IY81
Chr Location

17q23.3; chr17:63819433-63830012 (-) GRCh38

MGI Vertebrate Homology

Ftsj3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FTSJ3
Gene Tree

Ftsj3

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

11
Gene trapped

9
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

51
cDNA Data

204
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ftsj3

ZFIN ftsj3

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All Sequences

46
RefSeq

2
UniProt

1
CCDS

CCDS25552.1

Ensembl

ENSMUSG00000020706 (Evidence)
NCBI Gene

56095

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020706	Ensembl Gene Model \| MGI Sequence Detail	6938	C57BL/6J	± kb
transcript	ENSMUST00000021048	Ensembl \| MGI Sequence Detail	3144	Not Applicable
polypeptide	ENSMUSP00000021048	Ensembl \| MGI Sequence Detail	838	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029729 rRNA methyltransferase 3

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR028589 AdoMet-dependent rRNA methyltransferase SPB1-like

IPR015507 Ribosomal RNA large subunit methyltransferase E

IPR002877 Ribosomal RNA methyltransferase, FtsJ domain

IPR024576 Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381

IPR012920 Ribosomal RNA methyltransferase, SPB1-like, C-terminal

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 206

cDNA 204

Primer pair 2

Microarray probesets 3

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MGI:1196292, MGI:2144025, MGI:2144441, MGI:2144654

Summaries

All 35

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 4
Earliest

J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Ftsj3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111307	Chr11:106146871-106146929 (-)	5 bp
Tssr111306	Chr11:106146606-106146663 (-)	270 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23