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Ramp3
Gene Detail
Symbol

Name
ID
Ramp3
receptor (calcitonin) activity modifying protein 3
MGI:1860292
Feature Type
protein coding gene
Genetic Map
Chromosome 11
4.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:6658521-6677475 bp, + strand
From VEGA annotation of GRCm38

  18955 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RAMP3
Protein SuperFamily: receptor activity-modifying protein
Gene Tree: Ramp3

Human
homologs
RAMP3, receptor (G protein-coupled) activity modifying protein 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10268
neXtProt AC: NX_O60896

Human Chr (Location): 7p13-p12; chr7:45157768-45184250 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit decreased body weight at 6 months of age.
 
Interactions
Ramp3 interacts with 72 markers (Mir24-1, Mir24-2, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process calcium ion transport, cellular response to estradiol stimulus, ...
Component cell surface, integral component of membrane, ...
Function coreceptor activity, protein transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (73)    Tissues (34)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 61
Northern blot 12
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ramp3    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005124 (Evidence)
Ensembl Gene Model ENSMUSG00000041046 (Evidence)
Entrez Gene 56089 (Evidence)
UniGene 39884
DFCI TC1582884, TC1599237
DoTS DT.487173
NIA Mouse Gene Index U012304
Consensus CDS Project CCDS24425.1
International Mouse Phenotyping Consortium Status Ramp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005124 VEGA Gene Model | MGI Sequence Detail 18955 C57BL/6J ±  kb
transcript OTTMUST00000011472 VEGA | MGI Sequence Detail 1233 Not Applicable 
polypeptide OTTMUSP00000005341 VEGA | MGI Sequence Detail 147 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006985 Receptor activity modifying protein
Protein Ontology PR:000013707 receptor activity-modifying protein 3
References
(Earliest) J:61899 Ono Y, et al., Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem Biophys Res Commun. 2000 Apr 29;271(1):197-202
(Latest) J:201441 Lenhart PM, et al., G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection. J Mol Endocrinol. 2013 Aug;51(1):191-202
All references(39)
Other
accession IDs
MGI:2144304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory