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Ubqln2
Gene Detail
Symbol

Name
ID
Ubqln2
ubiquilin 2
MGI:1860283
Synonyms
Chap1, Dsk2, HRIHFB2157, Plic-2
Feature Type
protein coding gene
Genetic Map
Chromosome X
68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:153498227-153501570 bp, + strand
From VEGA annotation of GRCm38

  3344 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: UBQLN2
Gene Tree: Ubqln2

Human
homologs
UBQLN2, ubiquilin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29978
neXtProt AC: NX_Q9UHD9

Human Synonyms: ALS15, CHAP1, DSK2, HRIHFB2157, N4BP4, PLIC2

Human Chr (Location): Xp11.21; chrX:56563593-56567010 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human UBQLN2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Gene trapped(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ubqln2 interacts with 271 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process autophagy, ER-associated ubiquitin-dependent protein catabolic process, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000019381 (Evidence)
Ensembl Gene Model ENSMUSG00000050148 (Evidence)
Entrez Gene 54609 (Evidence)
DFCI TC1574265
DoTS DT.50315965, DT.91342023
NIA Mouse Gene Index U020340
Consensus CDS Project CCDS30482.1
International Mouse Phenotyping Consortium Status Ubqln2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019381 VEGA Gene Model | MGI Sequence Detail 3344 C57BL/6J ±  kb
transcript OTTMUST00000046253 VEGA | MGI Sequence Detail 3344 Not Applicable 
polypeptide OTTMUSP00000020893 VEGA | MGI Sequence Detail 638 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR006636 Heat shock chaperonin-binding
InterPro IPR009060 UBA-like
InterPro IPR015496 Ubiquilin
InterPro IPR000626 Ubiquitin
InterPro IPR000449 Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology PR:000017008 ubiquilin-2
References
(Earliest) J:62988 Wu AL, et al., Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol Cell. 1999 Oct;4(4):619-25
(Latest) J:206933 Farg MA, et al., C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet. 2014 Feb 27;
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory