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Ubqln2 Gene Detail
Summary
  • Symbol
    Ubqln2
  • Name
    ubiquilin 2
  • Synonyms
    Chap1, Dsk2, HRIHFB2157, Plic-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860283
    NCBI Gene: 54609
  • Gene Overview
    MyGene.info: UBQLN2
Location & Maps
more
  • Sequence Map
    ChrX:153498227-153501570 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3344 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    UBQLN2, ubiquilin 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    UBQLN2, ubiquilin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALS15, CHAP1, DSK2, HRIHFB2157, N4BP4, PLIC2
  • Links
    NCBI Gene ID: 29978
    neXtProt AC: NX_Q9UHD9

  • Chr Location
    Xp11.21; chrX:56563593-56567010 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human UBQLN2 associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 15 with or without Frontotemporal Dementia;   OMIM: 300857
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019381 VEGA Gene Model | MGI Sequence Detail 3344 C57BL/6J ±  kb
transcript OTTMUST00000046253 VEGA | MGI Sequence Detail 3344 Not Applicable  
polypeptide OTTMUSP00000020893 VEGA | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    10 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Other 1

    Microarray probesets 7
References
more
  • Summaries
    All 23
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:62988 Wu AL, et al., Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol Cell. 1999 Oct;4(4):619-25
  • Latest
    J:206933 Farg MA, et al., C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet. 2014 Feb 27;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory