About   Help   FAQ
Ubqln2 Gene Detail
Summary
  • Symbol
    Ubqln2
  • Name
    ubiquilin 2
  • Synonyms
    Chap1, Dsk2, HRIHFB2157, Plic-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860283
    NCBI Gene: 54609
  • Gene Overview
    MyGene.info: UBQLN2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:153498232-153501562 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860283
protein coding gene ChrX:153498227-153501570 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036195
protein coding gene ChrX:151318044-151321372 (+)
A/J MGP_AJ_G0036171
protein coding gene ChrX:150501356-150504700 (+)
AKR/J MGP_AKRJ_G0036097
protein coding gene ChrX:155343843-155347229 (+)
BALB/cJ MGP_BALBcJ_G0036162
protein coding gene ChrX:148675157-148678501 (+)
C3H/HeJ MGP_C3HHeJ_G0035870
protein coding gene ChrX:151577324-151580668 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036687
protein coding gene ChrX:155706928-155710271 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033511
protein coding gene ChrX:142164807-142168142 (+)
CAST/EiJ MGP_CASTEiJ_G0035161
protein coding gene ChrX:130882129-130885468 (+)
CBA/J MGP_CBAJ_G0035847
protein coding gene ChrX:160198558-160201882 (+)
DBA/2J MGP_DBA2J_G0036005
protein coding gene ChrX:149559145-149562450 (+)
FVB/NJ MGP_FVBNJ_G0035939
protein coding gene ChrX:148680752-148684084 (+)
LP/J MGP_LPJ_G0036096
protein coding gene ChrX:152394320-152397702 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035975
protein coding gene ChrX:168446746-168450090 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036722
protein coding gene ChrX:150841453-150844797 (+)
PWK/PhJ MGP_PWKPhJ_G0034855
protein coding gene ChrX:127833419-127836750 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034680
protein coding gene ChrX:131316860-131320205 (+)
WSB/EiJ MGP_WSBEiJ_G0035296
protein coding gene ChrX:148872345-148875689 (+)



Homology
more
  • Human Ortholog
    UBQLN2, ubiquilin 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    UBQLN2, ubiquilin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS15, CHAP1, DSK2, HRIHFB2157, N4BP4, PLIC2
  • Links
    NCBI Gene ID: 29978
    neXtProt AC: NX_Q9UHD9
    UniProt: Q9UHD9

  • Chr Location
    Xp11.21; chrX:56563593-56567010 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human UBQLN2 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from multigenic genotypes
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54609 NCBI Gene Model | MGI Sequence Detail 3331 C57BL/6J ±  kb
transcript NM_018798 RefSeq | MGI Sequence Detail 3343 C57BL/6  
polypeptide Q9QZM0 UniProt | EBI | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Other 1

    Microarray probesets 7
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:62988 Wu AL, et al., Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol Cell. 1999 Oct;4(4):619-25
  • Latest
    J:239510 Le NT, et al., Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7580-E7589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory