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Ubqln1 Gene Detail
Summary
  • Symbol
    Ubqln1
  • Name
    ubiquilin 1
  • Synonyms
    1110046H03Rik, 1810030E05Rik, D13Ertd372e, DA41, Dsk2, Plic-1, XDRP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860276
    NCBI Gene: 56085
  • Gene Overview
    MyGene.info: UBQLN1
Location & Maps
more
  • Sequence Map
    Chr13:58176156-58215653 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39498 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.95 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    UBQLN1, ubiquilin 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    UBQLN1, ubiquilin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DA41, DSK2, PLIC-1, UBQN, XDRP1
  • Links
    NCBI Gene ID: 29979
    neXtProt AC: NX_Q9UMX0

  • Chr Location
    9q22; chr9:83659963-83708253 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Ubqln1
  • Incidental Mutations
Homozygous null animals display impaired degradation of ubiquitinated proteins in the brain, increased ischemia/reperfusion-caused brain injury, and slower functional recovery after injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56085 NCBI Gene Model | MGI Sequence Detail 39498 C57BL/6J ±  kb
transcript NM_026842 RefSeq | MGI Sequence Detail 3693 C57BL/6  
polypeptide Q8R317 UniProt | EBI | MGI Sequence Detail 582 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    192 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 257
    cDNA 256
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1196410, MGI:1916055, MGI:1917327, MGI:2145351, MGI:2145489
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:62988 Wu AL, et al., Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol Cell. 1999 Oct;4(4):619-25
  • Latest
    J:228828 Hamazaki J, et al., Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. PLoS Genet. 2015 Jul;11(7):e1005401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory