Set MGI Mouse Gene Detail - MGI:1860267

Symbol

Set
Name

SET nuclear oncogene
Synonyms

2610030F17Rik, 5730420M11Rik, StF-IT-1

Feature Type

protein coding gene
IDs

MGI:1860267
NCBI Gene: 56086
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr2:29952074-29962589 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.09 cM
Mapping Data

2 experiments

SNPs within 2kb

432 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860267	protein coding gene	Chr2:29947390-29962589 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025551	protein coding gene	Chr2:28256669-28276207 (+)
A/J	MGP_AJ_G0025529	protein coding gene	Chr2:27131675-27149029 (+)
AKR/J	MGP_AKRJ_G0025498	protein coding gene	Chr2:28057067-28072770 (+)
BALB/cJ	MGP_BALBcJ_G0025524	protein coding gene	Chr2:27263836-27279196 (+)
C3H/HeJ	MGP_C3HHeJ_G0025286	protein coding gene	Chr2:27983683-28001414 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025969	protein coding gene	Chr2:29162908-29186028 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023378	protein coding gene	Chr2:25934572-25945539 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0025263	protein coding gene	Chr2:30185651-30204597 (+)
DBA/2J	MGP_DBA2J_G0025396	protein coding gene	Chr2:26927018-26940426 (+)
FVB/NJ	MGP_FVBNJ_G0025359	protein coding gene	Chr2:26734843-26750055 (+)
LP/J	MGP_LPJ_G0025482	protein coding gene	Chr2:28170902-28188572 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025389	protein coding gene	Chr2:30090186-30106374 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026028	protein coding gene	Chr2:27978198-27993649 (+)
PWK/PhJ	MGP_PWKPhJ_G0024495	protein coding gene	Chr2:26765542-26774368 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024295	protein coding gene	Chr2:28058868-28068290 (+)
WSB/EiJ	no annotation

Human Ortholog

SET, SET nuclear proto-oncogene

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SET, SET nuclear proto-oncogene
Synonyms

2PP2A, I2PP2A, IGAAD, IPP2A2, MRD58, PHAPII, TAF-I, TAF-IBETA
Links

HGNC:10760

NCBI Gene ID: 6418

UniProt: Q01105
Chr Location

9q34.11; chr9:128683424-128696400 (+) GRCh38

Human Ortholog

SETSIP, SET like protein
Synonyms

SETP18
Links

HGNC:42937

NCBI Gene ID: 646817

UniProt: P0DME0
Chr Location

1p22.1; chr1:92074533-92075411 (-) GRCh38

MGI Vertebrate Homology

Set stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SET, SETSIP
Gene Tree

Set

Diseases

1 with human SET associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder 58 IDs autosomal dominant intellectual developmental disorder 58 DOID:0061032 OMIM:618106

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

47
Endonuclease-mediated

4
Gene trapped

38
Targeted

5
Incidental Mutations

CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display complete lethality during organogenesis with reduced embryo size, cardiac edema and an open neural tube.

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All GO Annotations

40
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

839
Tissues

112
cDNA Data

21
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase set

ZFIN seta, setb

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All Sequences

64
RefSeq

4
UniProt

6
CCDS

CCDS15866.1, CCDS57162.1

Ensembl

ENSMUSG00000054766 (Evidence)
NCBI Gene

56086

			Length	Strain/Species	Flank
genomic	56086	NCBI Gene Model \| MGI Sequence Detail	10516	C57BL/6J	± kb
transcript	NM_001204875	RefSeq \| MGI Sequence Detail	2772	C57BL/6
polypeptide	Q9EQU5	UniProt \| EBI \| MGI Sequence Detail	289	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014717 protein SET

(term hierarchy)
InterPro Domains

IPR037231 NAP-like superfamily

IPR002164 Nucleosome assembly protein (NAP)
GlyGen

Q9EQU5 1 site, 1 O-linked glycan (1 site)

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All nucleic 28

cDNA 26

Primer pair 2

Microarray probesets 9

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MGI:1353597, MGI:1913553, MGI:1924886

Summaries

All 58

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 13
Earliest

J:307179 von Lindern M, et al., Can, a putative oncogene associated with myeloid leukemogenesis, may be activatd by fusion of its 3' half to different genes: characterization of the set gene. Mol Cell Biol. 1992 Aug;12(8):3346-55
Latest

J:335148 Zhang S, et al., SET/PP2A signaling regulates macrophage positioning in hypoxic tumor regions by amplifying chemotactic responses. Exp Mol Med. 2022 Oct;54(10):1741-1755

TSS for Set:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17062	Chr2:29951818-29951827 (+)	-251 bp
Tssr17063	Chr2:29951850-29951853 (+)	-222 bp
Tssr17064	Chr2:29951859-29951871 (+)	-209 bp
Tssr17065	Chr2:29951873-29951876 (+)	-199 bp
Tssr17066	Chr2:29951894-29951903 (+)	-175 bp
Tssr17067	Chr2:29951917-29951924 (+)	-153 bp
Tssr17068	Chr2:29951932-29951941 (+)	-137 bp
Tssr17069	Chr2:29951961-29951977 (+)	-105 bp
Tssr17070	Chr2:29952029-29952055 (+)	-32 bp
Tssr17071	Chr2:29952057-29952090 (+)	0 bp
Tssr17072	Chr2:29952102-29952110 (+)	32 bp
Tssr17073	Chr2:29952534-29952557 (+)	472 bp
Tssr17074	Chr2:29952563-29952582 (+)	499 bp
Tssr17075	Chr2:29952730-29952744 (+)	663 bp
Tssr17076	Chr2:29956431-29956473 (+)	4,378 bp
Tssr17077	Chr2:29956500-29956542 (+)	4,447 bp
Tssr17078	Chr2:29956550-29956579 (+)	4,491 bp
Tssr17079	Chr2:29956707-29956719 (+)	4,639 bp
Tssr17080	Chr2:29956721-29956735 (+)	4,654 bp
Tssr17081	Chr2:29956794-29956810 (+)	4,728 bp
Tssr17082	Chr2:29956811-29956833 (+)	4,748 bp
Tssr17083	Chr2:29956844-29956855 (+)	4,776 bp
Tssr17084	Chr2:29957171-29957199 (+)	5,111 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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