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Set Gene Detail
Summary
  • Symbol
    Set
  • Name
    SET nuclear oncogene
  • Synonyms
    2610030F17Rik, 5730420M11Rik, StF-IT-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860267
    NCBI Gene: 56086
  • Gene Overview
    MyGene.info: SET
  • Alliance
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30061996-30072577 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860267
protein coding gene Chr2:30057378-30072577 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025551
protein coding gene Chr2:28256669-28276207 (+)
A/J MGP_AJ_G0025529
protein coding gene Chr2:27131675-27149029 (+)
AKR/J MGP_AKRJ_G0025498
protein coding gene Chr2:28057067-28072770 (+)
BALB/cJ MGP_BALBcJ_G0025524
protein coding gene Chr2:27263836-27279196 (+)
C3H/HeJ MGP_C3HHeJ_G0025286
protein coding gene Chr2:27983683-28001414 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025969
protein coding gene Chr2:29162908-29186028 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023378
protein coding gene Chr2:25934572-25945539 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0025263
protein coding gene Chr2:30185651-30204597 (+)
DBA/2J MGP_DBA2J_G0025396
protein coding gene Chr2:26927018-26940426 (+)
FVB/NJ MGP_FVBNJ_G0025359
protein coding gene Chr2:26734843-26750055 (+)
LP/J MGP_LPJ_G0025482
protein coding gene Chr2:28170902-28188572 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025389
protein coding gene Chr2:30090186-30106374 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026028
protein coding gene Chr2:27978198-27993649 (+)
PWK/PhJ MGP_PWKPhJ_G0024495
protein coding gene Chr2:26765542-26774368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024295
protein coding gene Chr2:28058868-28068290 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SET, SET nuclear proto-oncogene
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SET, SET nuclear proto-oncogene
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2PP2A, I2PP2A, IGAAD, IPP2A2, MRD58, PHAPII, TAF-I, TAF-IBETA
  • Links
    NCBI Gene ID: 6418
    neXtProt AC: NX_Q01105
    UniProt: Q01105

  • Chr Location
    9q34.11; chr9:128683432-128696396 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from multigenic genotypes
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56086 NCBI Gene Model | MGI Sequence Detail 10582 C57BL/6J ±  kb
transcript NM_001204875 RefSeq | MGI Sequence Detail 2833 C57BL/6  
polypeptide Q9EQU5 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 9
Other
Accession IDs
less
MGI:1353597, MGI:1913553, MGI:1924886
References
more
  • Summaries
    All 47
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:62557 Compagnone NA, et al., Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis. Mol Endocrinol. 2000 Jun;14(6):875-88
  • Latest
    J:251944 Krishnan S, et al., Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis. Mol Cell. 2017 Aug 17;67(4):579-593.e6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory