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Set Gene Detail
Summary
  • Symbol
    Set
  • Name
    SET nuclear oncogene
  • Synonyms
    2610030F17Rik, 5730420M11Rik, StF-IT-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860267
    NCBI Gene: 56086
  • Gene Overview
    MyGene.info: SET
Location & Maps
more
  • Sequence Map
    Chr2:30057378-30072577 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15200 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.09 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SET, SET nuclear proto-oncogene
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SET, SET nuclear proto-oncogene
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA
  • Links
    NCBI Gene ID: 6418
    neXtProt AC: NX_Q01105

  • Chr Location
    9q34; chr9:128683432-128696396 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    56
  • Gene trapped
    52
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
    CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    20
  • Tissues
    19
  • cDNA Data
    18
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016726 VEGA Gene Model | MGI Sequence Detail 15200 C57BL/6J ±  kb
transcript OTTMUST00000040518 VEGA | MGI Sequence Detail 2824 Not Applicable  
polypeptide OTTMUSP00000018110 VEGA | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    10 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000014717 protein SET
  • InterPro Domains
    IPR002164 Nucleosome assembly protein (NAP)
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 9
Other
Accession IDs
less
MGI:1353597, MGI:1913553, MGI:1924886
References
more
  • Summaries
    All 42
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:62557 Compagnone NA, et al., Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis. Mol Endocrinol. 2000 Jun;14(6):875-88
  • Latest
    J:200659 Qi ST, et al., Overexpression of SETbeta, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes. J Cell Sci. 2013 Apr 1;126(Pt 7):1595-603
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory