Set MGI Mouse Gene Detail - MGI:1860267

Symbol

Set
Name

SET nuclear oncogene
Synonyms

2610030F17Rik, 5730420M11Rik, StF-IT-1

Feature Type

protein coding gene
IDs

MGI:1860267
NCBI Gene: 56086
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr2:29952008-29962589 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.09 cM
Mapping Data

2 experiments

SNPs within 2kb

5 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860267	protein coding gene	Chr2:29947390-29962589 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025551	protein coding gene	Chr2:28256669-28276207 (+)
A/J	MGP_AJ_G0025529	protein coding gene	Chr2:27131675-27149029 (+)
AKR/J	MGP_AKRJ_G0025498	protein coding gene	Chr2:28057067-28072770 (+)
BALB/cJ	MGP_BALBcJ_G0025524	protein coding gene	Chr2:27263836-27279196 (+)
C3H/HeJ	MGP_C3HHeJ_G0025286	protein coding gene	Chr2:27983683-28001414 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025969	protein coding gene	Chr2:29162908-29186028 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023378	protein coding gene	Chr2:25934572-25945539 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0025263	protein coding gene	Chr2:30185651-30204597 (+)
DBA/2J	MGP_DBA2J_G0025396	protein coding gene	Chr2:26927018-26940426 (+)
FVB/NJ	MGP_FVBNJ_G0025359	protein coding gene	Chr2:26734843-26750055 (+)
LP/J	MGP_LPJ_G0025482	protein coding gene	Chr2:28170902-28188572 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025389	protein coding gene	Chr2:30090186-30106374 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026028	protein coding gene	Chr2:27978198-27993649 (+)
PWK/PhJ	MGP_PWKPhJ_G0024495	protein coding gene	Chr2:26765542-26774368 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024295	protein coding gene	Chr2:28058868-28068290 (+)
WSB/EiJ	no annotation

Human Ortholog

SET, SET nuclear proto-oncogene

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SET, SET nuclear proto-oncogene
Synonyms

2PP2A, I2PP2A, IGAAD, IPP2A2, MRD58, PHAPII, TAF-I, TAF-IBETA
Links

HGNC:10760

NCBI Gene ID: 6418

neXtProt AC: NX_Q01105

UniProt: Q01105
Chr Location

9q34.11; chr9:128683432-128696396 (+) GRCh38.p7

Human Ortholog

SETSIP, SET like protein
Synonyms

SETP18
Links

HGNC:42937

NCBI Gene ID: 646817

neXtProt AC: NX_P0DME0

UniProt: P0DME0
Chr Location

1p22.1; chr1:92074436-92075472 (-) GRCh38.p7

Alliance of Genome Resources

Set stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SET, SETSIP
Gene Tree

Set

Diseases

1 with human SET associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder IDs autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200 ORDO:178469

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Endonuclease-mediated

2
Gene trapped

38
Targeted

5
Transgenic

1
Incidental Mutations

CvDC
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display complete lethality during organogenesis with reduced embryo size, cardiac edema and an open neural tube.

less

All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

839
Tissues

112
cDNA Data

21
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase set

ZFIN seta, setb

less

Set interacts with 305 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

less

All Sequences

64
RefSeq

4
UniProt

6
CCDS

CCDS15866.1, CCDS57162.1

Ensembl

ENSMUSG00000054766 (Evidence)
NCBI Gene

56086

			Length	Strain/Species	Flank
genomic	56086	NCBI Gene Model \| MGI Sequence Detail	10582	C57BL/6J	± kb
transcript	NM_001204875	RefSeq \| MGI Sequence Detail	2772	C57BL/6
polypeptide	Q9EQU5	UniProt \| EBI \| MGI Sequence Detail	289	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000014717 protein SET

(term hierarchy)
InterPro Domains

IPR037231 NAP-like superfamily

IPR002164 Nucleosome assembly protein (NAP)

less

All nucleic 28

cDNA 26

Primer pair 2

Microarray probesets 9

less

MGI:1353597, MGI:1913553, MGI:1924886

Summaries

All 54

Developmental Gene Expression 9

Diseases 1

Gene Ontology 6

Phenotypes 13
Earliest

J:307179 von Lindern M, et al., Can, a putative oncogene associated with myeloid leukemogenesis, may be activatd by fusion of its 3' half to different genes: characterization of the set gene. Mol Cell Biol. 1992 Aug;12(8):3346-55
Latest

J:302708 Liu HB, et al., RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Adv Sci (Weinh). 2019 Aug 7;6(15):1900295

TSS for Set:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17062	Chr2:29951818-29951827 (+)	-185 bp
Tssr17063	Chr2:29951850-29951853 (+)	-156 bp
Tssr17064	Chr2:29951859-29951871 (+)	-143 bp
Tssr17065	Chr2:29951873-29951876 (+)	-133 bp
Tssr17066	Chr2:29951894-29951903 (+)	-109 bp
Tssr17067	Chr2:29951917-29951924 (+)	-87 bp
Tssr17068	Chr2:29951932-29951941 (+)	-71 bp
Tssr17069	Chr2:29951961-29951977 (+)	-39 bp
Tssr17070	Chr2:29952029-29952055 (+)	34 bp
Tssr17071	Chr2:29952057-29952090 (+)	66 bp
Tssr17072	Chr2:29952102-29952110 (+)	98 bp
Tssr17073	Chr2:29952534-29952557 (+)	538 bp
Tssr17074	Chr2:29952563-29952582 (+)	565 bp
Tssr17075	Chr2:29952730-29952744 (+)	729 bp
Tssr17076	Chr2:29956431-29956473 (+)	4,444 bp
Tssr17077	Chr2:29956500-29956542 (+)	4,513 bp
Tssr17078	Chr2:29956550-29956579 (+)	4,557 bp
Tssr17079	Chr2:29956707-29956719 (+)	4,705 bp
Tssr17080	Chr2:29956721-29956735 (+)	4,720 bp
Tssr17081	Chr2:29956794-29956810 (+)	4,794 bp
Tssr17082	Chr2:29956811-29956833 (+)	4,814 bp
Tssr17083	Chr2:29956844-29956855 (+)	4,842 bp
Tssr17084	Chr2:29957171-29957199 (+)	5,177 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/27/2022 MGI 6.21