Set MGI Mouse Gene Detail - MGI:1860267

Set Gene Detail

Symbol

Set
Name

SET nuclear oncogene
Synonyms

2610030F17Rik, 5730420M11Rik, StF-IT-1

Feature Type

protein coding gene
IDs

MGI:1860267
NCBI Gene: 56086
Gene Overview

MyGene.info: SET

Sequence Map

Chr2:30057378-30072577 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

15200 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.09 cM
Mapping Data

2 experiments

Human Ortholog

SET, SET nuclear proto-oncogene

Vertebrate Orthologs

10

Human Ortholog

SET, SET nuclear proto-oncogene
Orthology source: HomoloGene, HGNC
Synonyms

2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA
Links

HGNC:10760

NCBI Gene ID: 6418

neXtProt AC: NX_Q01105

UniProt: Q01105
Chr Location

9q34.11; chr9:128683432-128696396 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55707
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SET
Protein SuperFamily

template activating factor I
Gene Tree

Set

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

13 phenotypes from multigenic genotypes
9 phenotype references

All Mutations and Alleles

56
Gene trapped

52
Targeted

3
Transgenic

1
Incidental Mutations

CvDC
Find Mice (IMSR)

53 strains or lines available

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All GO Annotations

12
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

20
Tissues

19
cDNA Data

18
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN seta, setb

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Set interacts with 305 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

60
RefSeq

4
UniProt

6
CCDS

CCDS15866.1, CCDS57162.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016726	VEGA Gene Model \| MGI Sequence Detail	15200	C57BL/6J	± kb
transcript	OTTMUST00000040518	VEGA \| MGI Sequence Detail	2824	Not Applicable
polypeptide	OTTMUSP00000018110	VEGA \| MGI Sequence Detail	289	Not Applicable

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SNPs within 2kb

10 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000014717 protein SET

(term hierarchy)
InterPro Domains

IPR002164 Nucleosome assembly protein (NAP)

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All nucleic 21

cDNA 21

Microarray probesets 9

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MGI:1353597, MGI:1913553, MGI:1924886

Summaries

All 43

Developmental Gene Expression 7

Diseases 1

Gene Ontology 5

Phenotypes 9
Earliest

J:62557 Compagnone NA, et al., Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis. Mol Endocrinol. 2000 Jun;14(6):875-88
Latest

J:200659 Qi ST, et al., Overexpression of SETbeta, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes. J Cell Sci. 2013 Apr 1;126(Pt 7):1595-603

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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