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Wdr7 Gene Detail
Summary
  • Symbol
    Wdr7
  • Name
    WD repeat domain 7
  • Synonyms
    mKIAA0541, TGF-beta resistance associated gene, TRAG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860197
    NCBI Gene: 104082
Location & Maps
more
  • Sequence Map
    Chr18:63708695-63989760 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      281066 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 37.09 cM, cytoband D1-E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WDR7, WD repeat domain 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDR7, WD repeat domain 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TRAG
  • Links
    NCBI Gene ID: 23335
    neXtProt AC: NX_Q9Y4E6

  • Chr Location
    18q21.31; chr18:56651343-57029805 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11408
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: WDR7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 104082 NCBI Gene Model | MGI Sequence Detail 281066 C57BL/6J ±  kb
transcript NM_001014981 RefSeq | MGI Sequence Detail 7109 C57BL/6  
polypeptide Q920I9 UniProt | EBI | MGI Sequence Detail 1489 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1291 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000031394 WD repeat-containing protein 7
  • InterPro Domains
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 50
    Genomic 1
    cDNA 49

    Microarray probesets 3
Other
Accession IDs
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MGI:2147236
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:62790 Sanders S, et al., Assignment of WDR7 (alias TRAG, TGF-beta resistance associated gene) to orthologous regions of human chromosome 18q21.1-->q22 and mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization. Cytogenet Cell Genet. 2000;88(3-4):324-5
  • Latest
    J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory