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Polm Gene Detail
Summary
  • Symbol
    Polm
  • Name
    polymerase (DNA directed), mu
  • Synonyms
    B230309I03Rik, Tdt-N
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860191
    NCBI Gene: 54125
  • Gene Overview
    MyGene.info: POLM
Location & Maps
more
  • Genetic Map
    Chromosome 11, 3.87 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    POLM, DNA polymerase mu
  • Vertebrate Orthologs
    8
  • Human Ortholog
    POLM, DNA polymerase mu
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Pol Mu, Tdt-N
  • Links
    NCBI Gene ID: 27434
    neXtProt AC: NX_Q9NP87

  • Chr Location
    7p13; chr7:44072062-44082540 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, B cell maturation and proliferation is abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005101 VEGA Gene Model | MGI Sequence Detail 9934 C57BL/6J ±  kb
transcript OTTMUST00000011409 VEGA | MGI Sequence Detail 2697 Not Applicable  
polypeptide OTTMUSP00000005316 VEGA | MGI Sequence Detail 511 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012979 DNA-directed DNA/RNA polymerase mu
  • PDB
  • EC
  • InterPro Domains
    IPR001357 BRCT domain
    IPR002054 DNA-directed DNA polymerase X
    IPR027249 DNA-directed DNA/RNA polymerase mu
    IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
    IPR010996 DNA polymerase beta-like, N-terminal domain
    IPR028207 DNA polymerase beta, palm domain
    IPR029398 DNA polymerase beta, thumb domain
    IPR022312 DNA polymerase family X
    IPR019843 DNA polymerase family X, binding site
    IPR027421 DNA polymerase family X lyase domain
    IPR018944 DNA polymerase lambda, fingers domain
Molecular
Reagents
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  • All nucleic 41
    cDNA 41

    Microarray probesets 3
Other
Accession IDs
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MGI:2144181, MGI:2443119
References
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  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:64833 Aoufouchi S, et al., Two novel human and mouse DNA polymerases of the polX family. Nucleic Acids Res. 2000 Sep 15;28(18):3684-93
  • Latest
    J:229253 Spies N, et al., Constraint and divergence of global gene expression in the mammalian embryo. Elife. 2015;4:e05538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory