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Polm Gene Detail
Summary
  • Symbol
    Polm
  • Name
    polymerase (DNA directed), mu
  • Synonyms
    B230309I03Rik, Tdt-N
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860191
    NCBI Gene: 54125
  • Gene Overview
    MyGene.info: POLM
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5827860-5838016 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860191
protein coding gene Chr11:5827860-5838342 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018008
protein coding gene Chr11:2910774-2920927 (-)
A/J MGP_AJ_G0017981
protein coding gene Chr11:2795271-2805420 (-)
AKR/J MGP_AKRJ_G0017945
protein coding gene Chr11:2947398-2957547 (-)
BALB/cJ MGP_BALBcJ_G0017949
protein coding gene Chr11:2786085-2796215 (-)
C3H/HeJ MGP_C3HHeJ_G0017762
protein coding gene Chr11:2816512-2826545 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018401
protein coding gene Chr11:2988792-2998944 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016059
protein coding gene Chr11:2695086-2705996 (-)
CAST/EiJ MGP_CASTEiJ_G0017324
protein coding gene Chr11:2784144-2794177 (-)
CBA/J MGP_CBAJ_G0017737
protein coding gene Chr11:3345382-3360804 (-)
DBA/2J MGP_DBA2J_G0017847
protein coding gene Chr11:2703078-2713517 (-)
FVB/NJ MGP_FVBNJ_G0017839
protein coding gene Chr11:2731210-2741346 (-)
LP/J MGP_LPJ_G0017918
protein coding gene Chr11:2989750-2999717 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017865
protein coding gene Chr11:2958605-2968765 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018441
protein coding gene Chr11:2947972-2958108 (-)
PWK/PhJ MGP_PWKPhJ_G0017104
protein coding gene Chr11:2726161-2736786 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016901
protein coding gene Chr11:2914394-2924891 (-)
WSB/EiJ MGP_WSBEiJ_G0017378
protein coding gene Chr11:2788663-2798819 (-)



Homology
more
  • Human Ortholog
    POLM, DNA polymerase mu
  • Vertebrate Orthologs
    8
  • Human Ortholog
    POLM, DNA polymerase mu
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Pol Mu, Tdt-N
  • Links
    NCBI Gene ID: 27434
    neXtProt AC: NX_Q9NP87
    UniProt: Q9NP87

  • Chr Location
    7p13; chr7:44072062-44082540 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, B cell maturation and proliferation is abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020474 Ensembl Gene Model | MGI Sequence Detail 10157 C57BL/6J ±  kb
transcript ENSMUST00000109837 Ensembl | MGI Sequence Detail 2697 Not Applicable  
polypeptide ENSMUSP00000105463 Ensembl | MGI Sequence Detail 511 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • PDB
  • EC
  • InterPro Domains
    IPR001357 BRCT domain
    IPR036420 BRCT domain superfamily
    IPR002054 DNA-directed DNA polymerase X
    IPR027249 DNA-directed DNA/RNA polymerase mu
    IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
    IPR010996 DNA polymerase beta-like, N-terminal domain
    IPR028207 DNA polymerase beta, palm domain
    IPR029398 DNA polymerase beta, thumb domain
    IPR022312 DNA polymerase family X
    IPR019843 DNA polymerase family X, binding site
    IPR018944 DNA polymerase lambda, fingers domain
    IPR027421 DNA polymerase lambda lyase domain superfamily
    IPR037160 DNA polymerase, thumb domain superfamily
Molecular
Reagents
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  • All nucleic 42
    cDNA 42

    Microarray probesets 3
Other
Accession IDs
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MGI:2144181, MGI:2443119
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:61446 Dominguez O, et al., DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. EMBO J. 2000 Apr 3;19(7):1731-42
  • Latest
    J:229253 Spies N, et al., Constraint and divergence of global gene expression in the mammalian embryo. Elife. 2015;4:e05538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory