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Polm
Gene Detail
Symbol

Name
ID
Polm
polymerase (DNA directed), mu
MGI:1860191
Synonyms
B230309I03Rik, Tdt-N
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:5827860-5837793 bp, - strand
From VEGA annotation of GRCm38

  9934 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41170  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POLM
Protein SuperFamily: DNA nucleotidyltransferase
Gene Tree: Polm

Human
homologs
POLM, polymerase (DNA directed), mu
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 27434
neXtProt AC: NX_Q9NP87

Human Synonyms: Pol Mu, Tdt-N

Human Chr (Location): 7p13; chr7:44072062-44082540 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, B cell maturation and proliferation is abnormal.
 
Interactions
Polm interacts with 171 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process B cell differentiation, cellular response to DNA damage stimulus, ...
Component nucleoplasm, nucleus
Function DNA binding, DNA-directed DNA polymerase activity, ...
External Resources: FuncBase
Expression
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase polm ; ZFIN polm    NEW 
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005101 (Evidence)
Ensembl Gene Model ENSMUSG00000020474 (Evidence)
Entrez Gene 54125 (Evidence)
UniGene 260194
DFCI TC1578161, TC1598677
DoTS DT.101208622, DT.101223357, DT.529264, DT.94201161
NIA Mouse Gene Index U032475
EC 2.7.7.7
PDB 2IHM
Consensus CDS Project CCDS24405.1
International Mouse Phenotyping Consortium Status Polm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005101 VEGA Gene Model | MGI Sequence Detail 9934 C57BL/6J ±  kb
transcript OTTMUST00000011409 VEGA | MGI Sequence Detail 2697 Not Applicable 
polypeptide OTTMUSP00000005316 VEGA | MGI Sequence Detail 511 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR002054 DNA-directed DNA polymerase X
InterPro IPR027249 DNA-directed DNA/RNA polymerase mu
InterPro IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
InterPro IPR010996 DNA polymerase beta-like, N-terminal domain
InterPro IPR028207 DNA polymerase beta, palm domain
InterPro IPR029398 DNA polymerase beta, thumb domain
InterPro IPR022312 DNA polymerase family X
InterPro IPR019843 DNA polymerase family X, binding site
InterPro IPR027421 DNA polymerase family X lyase domain
InterPro IPR018944 DNA polymerase lambda, fingers domain
Protein Ontology PR:000012979 DNA-directed DNA/RNA polymerase mu
References
(Earliest) J:64833 Aoufouchi S, et al., Two novel human and mouse DNA polymerases of the polX family. Nucleic Acids Res. 2000 Sep 15;28(18):3684-93
(Latest) J:215044 Escudero B, et al., Polmu deficiency increases resistance to oxidative damage and delays liver aging. PLoS One. 2014;9(4):e93074
All references(38)
Other
accession IDs
MGI:2144181, MGI:2443119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory