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Polm
Gene Detail
 Symbol
Name
ID
Polm
polymerase (DNA directed), mu
MGI:1860191
Synonyms B230309I03Rik, Tdt-N
Feature Type protein coding gene
Genetic Map
Chromosome 11
3.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:5827860-5837793 bp, - strand
From VEGA annotation of GRCm38

  9934 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41170  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA nucleotidyltransferase
Gene Tree: Polm

Human
homologs
Human Homolog POLM, polymerase (DNA directed), mu
NCBI Gene ID 27434
neXtProt AC  NX_Q9NP87
Human Synonyms  Pol Mu, Tdt-N
Human Chr (Location)  7p13; chr7:44072062-44082540 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, B cell maturation and proliferation is abnormal.
 
Interactions
Polm interacts with 171 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process B cell differentiation, cellular response to DNA damage stimulus, ...
Component nucleus
Function DNA binding, DNA-directed DNA polymerase activity, ...
External Resources: FuncBase
Expression
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005101 (Evidence)
Ensembl Gene ModelENSMUSG00000020474 (Evidence)
Entrez Gene54125 (Evidence)
UniGene260194
DFCITC1578161, TC1598677
DoTSDT.101208622, DT.101223357, DT.529264, DT.94201161
NIA Mouse Gene IndexU032475
EC2.7.7.7
PDB2IHM
Consensus CDS ProjectCCDS24405.1
International Mouse Knockout Project StatusPolm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005101 VEGA Gene Model | MGI Sequence Detail 9934 C57BL/6J ±  kb
transcript OTTMUST00000011409 VEGA | MGI Sequence Detail 2697 Not Applicable 
polypeptide OTTMUSP00000005316 VEGA | MGI Sequence Detail 511 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR002054 DNA-directed DNA polymerase X
InterPro IPR027249 DNA-directed DNA/RNA polymerase mu
InterPro IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
InterPro IPR010996 DNA polymerase beta-like, N-terminal domain
InterPro IPR022312 DNA polymerase family X
InterPro IPR019843 DNA polymerase family X, binding site
InterPro IPR027421 DNA polymerase family X lyase domain
InterPro IPR018944 DNA polymerase lambda, fingers domain
Protein Ontology PR:000012979 DNA-directed DNA/RNA polymerase mu
References (Earliest) J:64833 Aoufouchi S, et al., Two novel human and mouse DNA polymerases of the polX family. Nucleic Acids Res. 2000 Sep 15;28(18):3684-93
(Latest) J:195819 Lucas D, et al., Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase mu. PLoS One. 2013;8(1):e53243
All references(36)
Other
accession IDs
MGI:2144181, MGI:2443119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory