Npffr2 MGI Mouse Gene Detail - MGI:1860130 - neuropeptide FF receptor 2

Symbol

Npffr2
Name

neuropeptide FF receptor 2
Synonyms

Gpr74, NPFF2

Feature Type

protein coding gene
IDs

MGI:1860130
NCBI Gene: 104443
Alliance

genome feature page

Sequence Map

Chr5:89675288-89731599 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 44.32 cM
Mapping Data

2 experiments

SNPs within 2kb

1644 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860130	protein coding gene	Chr5:89674805-89731599 (+)
129S1/SvImJ	ENSMUSG00200008160	protein coding gene	Chr5:85390509-85444020 (+)
A/J	ENSMUSG00195024720	protein coding gene	Chr5:84577603-84633917 (+)
AKR/J	ENSMUSG00220011301	protein coding gene	Chr5:84720825-84777138 (+)
BALB/cJ	ENSMUSG00180023316	protein coding gene	Chr5:84413866-84476015 (+)
C3H/HeJ	ENSMUSG00175042729	protein coding gene	Chr5:86509161-86571309 (+)
C57BL/6NJ	ENSMUSG00215025586	protein coding gene	Chr5:85270513-85326827 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027382	protein coding gene	Chr5:82746388-82797229 (+)
CAST/EiJ	ENSTCUG00005035334	protein coding gene	Chr5:84178046-84242495 (+)
CBA/J	ENSMUSG00210005974	protein coding gene	Chr5:85309060-85371210 (+)
DBA/2J	ENSMUSG00185037944	protein coding gene	Chr5:87223110-87285262 (+)
FVB/NJ	ENSMUSG00205019606	protein coding gene	Chr5:84111664-84174564 (+)
JF1/MsJ	ENSUMUG00000026154	protein coding gene	Chr5:91530658-91582835 (+)
LP/J	ENSMUSG00230024683	protein coding gene	Chr5:91916935-91970448 (+)
NOD/ShiLtJ	ENSMUSG00190033443	protein coding gene	Chr5:84177326-84239477 (+)
NZO/HlLtJ	ENSMUSG00225008129	protein coding gene	Chr5:97065150-97119708 (+)
PWK/PhJ	ENSLUMG00010027004	protein coding gene	Chr5:84185230-84237460 (+)
SPRET/EiJ	ENSMSPG00010028835	protein coding gene	Chr5:86597320-86649298 (+)
WSB/EiJ	ENSIUOG00005025432	protein coding gene	Chr5:87216449-87271621 (+)

Human Ortholog

NPFFR2, neuropeptide FF receptor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NPFFR2, neuropeptide FF receptor 2
Synonyms

GPR74, HLWAR77, NPFF2, NPGPR
Links

HGNC:4525

NCBI Gene ID: 10886

UniProt: Q9Y5X5
Chr Location

4q13.3; chr4:72031902-72148311 (+) GRCh38

MGI Vertebrate Homology

Npffr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NPFFR2
Gene Tree

Npffr2

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Phenotype Summary

31 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

10
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

4 involving Npffr2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased litter size and sex-specific increased susceptibility to diet-induced obesity and adipose accumulation, impaired diet-induced thermogenesis, and altered bone thickness.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

618
Tissues

7
cDNA Data

4
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase npffr2

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All Sequences

32
RefSeq

4
UniProt

2
CCDS

CCDS19408.1

Ensembl

ENSMUSG00000035528 (Evidence)
NCBI Gene

104443

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035528	Ensembl Gene Model \| MGI Sequence Detail	56312	C57BL/6J	± kb
transcript	ENSMUST00000048557	Ensembl \| MGI Sequence Detail	1643	Not Applicable
polypeptide	ENSMUSP00000040033	Ensembl \| MGI Sequence Detail	417	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001621 neuropeptide FF receptor 2

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR005395 Neuropeptide FF receptor family

IPR005397 Neuropeptide FF receptor, type 2
GlyGen

Q924H0 4 sites

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All nucleic 5

Genomic 1

cDNA 4

Microarray probesets 2

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:378491 Feetham CH, et al., Analog of prolactin-releasing peptide reduces body weight primarily through sustained fatty acid oxidation rather than hypophagia. Cell Metab. 2025 Dec 1;

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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