About   Help   FAQ
Slc2a8 Gene Detail
Summary
  • Symbol
    Slc2a8
  • Name
    solute carrier family 2, (facilitated glucose transporter), member 8
  • Synonyms
    D2Ertd44e, GLUT8, GlutX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860103
    NCBI Gene: 56017
Location & Maps
more
  • Sequence Map
    Chr2:32972990-32982083 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9094 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC2A8, solute carrier family 2 member 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC2A8, solute carrier family 2 member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUT8, GLUTX1
  • Links
    NCBI Gene ID: 29988
    neXtProt AC: NX_Q9NY64

  • Chr Location
    9q33.3; chr9:127397138-127407898 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69170
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC2A8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one null allele show reduced spermatozoan ATP levels, mitochondrial membrane potential and sperm motility, and a slight deviation from the expected Mendelian frequency. Homozygotes for another null allele show increased hippocampus cell proliferation and cardiac P-wave duration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012577 VEGA Gene Model | MGI Sequence Detail 9094 C57BL/6J ±  kb
transcript OTTMUST00000029967 VEGA | MGI Sequence Detail 2108 Not Applicable  
polypeptide OTTMUSP00000013476 VEGA | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    29 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000015071 solute carrier family 2, facilitated glucose transporter member 8
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR003663 Sugar/inositol transporter
    IPR005829 Sugar transporter, conserved site
Molecular
Reagents
less
  • All nucleic 41
    cDNA 40
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1098576
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:212440 Debosch BJ, et al., Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014 Apr 18;289(16):10989-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory