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Crlf3 Gene Detail
Summary
  • Symbol
    Crlf3
  • Name
    cytokine receptor-like factor 3
  • Synonyms
    Creme9, cytor4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860086
    NCBI Gene: 54394
  • Gene Overview
    MyGene.info: CRLF3
Location & Maps
more
  • Sequence Map
    Chr11:80046493-80080991 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      34499 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.43 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CRLF3, cytokine receptor like factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRLF3, cytokine receptor like factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CREME9, CREME-9, CRLM9, CYTOR4, FRWS, p48.2
  • Links
    NCBI Gene ID: 51379
    neXtProt AC: NX_Q8IUI8

  • Chr Location
    17q11.2; chr17:30782684-30824760 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 9327
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CRLF3
  • Gene Tree
    Crlf3
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    1
  • Gene trapped
    41
  • Targeted
    5
  • Genomic Mutations
    2 involving Crlf3
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    61
  • Tissues
    24
  • cDNA Data
    74
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000187 VEGA Gene Model | MGI Sequence Detail 34499 C57BL/6J ±  kb
transcript OTTMUST00000000558 VEGA | MGI Sequence Detail 2396 Not Applicable  
polypeptide OTTMUSP00000000242 VEGA | MGI Sequence Detail 442 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    130 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005887 cytokine receptor-like factor 3
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 75
    cDNA 75

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144610
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 23
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:213544 Ryder E, et al., Rapid conversion of EUCOMM/KOMP-CSD alleles in mouse embryos using a cell-permeable Cre recombinase. Transgenic Res. 2014 Feb;23(1):177-85
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory