Crlf3 MGI Mouse Gene Detail - MGI:1860086 - cytokine receptor-like factor 3

Symbol

Crlf3
Name

cytokine receptor-like factor 3
Synonyms

Creme9, cytor4

Feature Type

protein coding gene
IDs

MGI:1860086
NCBI Gene: 54394
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:79937319-79971817 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 47.43 cM
Mapping Data

3 experiments

SNPs within 2kb

2155 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860086	protein coding gene	Chr11:79937319-79971976 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018804	protein coding gene	Chr11:81180745-81216245 (-)
A/J	MGP_AJ_G0018771	protein coding gene	Chr11:78067210-78102251 (-)
AKR/J	MGP_AKRJ_G0018741	protein coding gene	Chr11:80413510-80448663 (-)
BALB/cJ	MGP_BALBcJ_G0018744	protein coding gene	Chr11:78455010-78490513 (-)
C3H/HeJ	MGP_C3HHeJ_G0018558	protein coding gene	Chr11:80461738-80495838 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019196	protein coding gene	Chr11:83671360-83707955 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016830	protein coding gene	Chr11:74998740-75031381 (-)
CAST/EiJ	MGP_CASTEiJ_G0018113	protein coding gene	Chr11:80933813-80973111 (-)
CBA/J	MGP_CBAJ_G0018529	protein coding gene	Chr11:87319801-87358629 (-)
DBA/2J	MGP_DBA2J_G0018637	protein coding gene	Chr11:77623154-77658105 (-)
FVB/NJ	MGP_FVBNJ_G0018626	protein coding gene	Chr11:77192273-77227609 (-)
LP/J	MGP_LPJ_G0018707	protein coding gene	Chr11:81707379-81742273 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018653	protein coding gene	Chr11:87607675-87643876 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019236	protein coding gene	Chr11:80662082-80697687 (-)
PWK/PhJ	MGP_PWKPhJ_G0017883	protein coding gene	Chr11:78427629-78462035 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017674	protein coding gene	Chr11:80252275-80286632 (-)
WSB/EiJ	MGP_WSBEiJ_G0018165	protein coding gene	Chr11:80493359-80528457 (-)

Human Ortholog

CRLF3, cytokine receptor like factor 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRLF3, cytokine receptor like factor 3
Synonyms

CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2
Links

HGNC:17177

NCBI Gene ID: 51379

UniProt: Q8IUI8
Chr Location

17q11.2; chr17:30769388-30824692 (-) GRCh38

MGI Vertebrate Homology

Crlf3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRLF3
Gene Tree

Crlf3

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Phenotype Summary

12 phenotypes from 4 alleles in 5 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

34
Targeted

6
Genomic Mutations

2 involving Crlf3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level. Heterozygosity for the p.L389P mutation leads to hippocampal neurons with shorter dendrites with fewer branches.

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All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

24
cDNA Data

75
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crlf3

ZFIN crlf3

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All Sequences

59
RefSeq

6
UniProt

4
CCDS

CCDS25126.1, CCDS70260.1

Ensembl

ENSMUSG00000017561 (Evidence)
NCBI Gene

54394

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017561	Ensembl Gene Model \| MGI Sequence Detail	34499	C57BL/6J	± kb
transcript	ENSMUST00000061283	Ensembl \| MGI Sequence Detail	2396	Not Applicable
polypeptide	ENSMUSP00000060028	Ensembl \| MGI Sequence Detail	442	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005887 cytokine receptor-like factor 3

(term hierarchy)
PDB

6RPX, 6RPY, 6RPZ
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

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All nucleic 76

cDNA 76

Microarray probesets 3

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MGI:2144610

Summaries

All 59

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 29
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Crlf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109535	Chr11:79972004-79972031 (-)	-201 bp
Tssr109534	Chr11:79971943-79971968 (-)	-139 bp
Tssr109533	Chr11:79971754-79971827 (-)	26 bp
Tssr109532	Chr11:79971734-79971745 (-)	77 bp
Tssr109531	Chr11:79954235-79954254 (-)	17,572 bp
Tssr109530	Chr11:79954093-79954116 (-)	17,712 bp
Tssr109529	Chr11:79944138-79944142 (-)	27,677 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24