Crlf3 MGI Mouse Gene Detail - MGI:1860086 - cytokine receptor-like factor 3

Symbol

Crlf3
Name

cytokine receptor-like factor 3
Synonyms

Creme9, cytor4

Feature Type

protein coding gene
IDs

MGI:1860086
NCBI Gene: 54394
Gene Overview

MyGene.info: CRLF3
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:80046493-80080991 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 47.43 cM
Mapping Data

3 experiments

SNPs within 2kb

130 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860086	protein coding gene	Chr11:80046493-80081160 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018804	protein coding gene	Chr11:81180745-81216245 (-)
A/J	MGP_AJ_G0018771	protein coding gene	Chr11:78067210-78102251 (-)
AKR/J	MGP_AKRJ_G0018741	protein coding gene	Chr11:80413510-80448663 (-)
BALB/cJ	MGP_BALBcJ_G0018744	protein coding gene	Chr11:78455010-78490513 (-)
C3H/HeJ	MGP_C3HHeJ_G0018558	protein coding gene	Chr11:80461738-80495838 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019196	protein coding gene	Chr11:83671360-83707955 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016830	protein coding gene	Chr11:74998740-75031381 (-)
CAST/EiJ	MGP_CASTEiJ_G0018113	protein coding gene	Chr11:80933813-80973111 (-)
CBA/J	MGP_CBAJ_G0018529	protein coding gene	Chr11:87319801-87358629 (-)
DBA/2J	MGP_DBA2J_G0018637	protein coding gene	Chr11:77623154-77658105 (-)
FVB/NJ	MGP_FVBNJ_G0018626	protein coding gene	Chr11:77192273-77227609 (-)
LP/J	MGP_LPJ_G0018707	protein coding gene	Chr11:81707379-81742273 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018653	protein coding gene	Chr11:87607675-87643876 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019236	protein coding gene	Chr11:80662082-80697687 (-)
PWK/PhJ	MGP_PWKPhJ_G0017883	protein coding gene	Chr11:78427629-78462035 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017674	protein coding gene	Chr11:80252275-80286632 (-)
WSB/EiJ	MGP_WSBEiJ_G0018165	protein coding gene	Chr11:80493359-80528457 (-)

Human Ortholog

CRLF3, cytokine receptor like factor 3

Vertebrate Orthologs

10

Human Ortholog

CRLF3, cytokine receptor like factor 3
Orthology source: HomoloGene, HGNC
Synonyms

CREME9, CREME-9, CRLM9, CYTOR4, FRWS, p48.2
Links

HGNC:17177

NCBI Gene ID: 51379

neXtProt AC: NX_Q8IUI8

UniProt: Q8IUI8
Chr Location

17q11.2; chr17:30782684-30824760 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9327
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CRLF3
Gene Tree

Crlf3

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Phenotype Summary

10 phenotypes from 3 alleles in 4 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

41
Targeted

6
Genomic Mutations

2 involving Crlf3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level.

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All GO Annotations

14
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

61
Tissues

24
cDNA Data

75
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crlf3

ZFIN crlf3

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Crlf3 interacts with 162 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

58
RefSeq

5
UniProt

4
CCDS

CCDS25126.1, CCDS70260.1
UniGene

272093

Ensembl

ENSMUSG00000017561 (Evidence)
NCBI Gene

54394

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017561	Ensembl Gene Model \| MGI Sequence Detail	34499	C57BL/6J	± kb
transcript	ENSMUST00000061283	Ensembl \| MGI Sequence Detail	2396	Not Applicable
polypeptide	ENSMUSP00000060028	Ensembl \| MGI Sequence Detail	442	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005887 cytokine receptor-like factor 3

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

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All nucleic 76

cDNA 76

Microarray probesets 3

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MGI:2144610

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 25
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Crlf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109535	Chr11:80081178-80081205 (-)	-201 bp
Tssr109534	Chr11:80081117-80081142 (-)	-139 bp
Tssr109533	Chr11:80080928-80081001 (-)	26 bp
Tssr109532	Chr11:80080908-80080919 (-)	77 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13