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Crlf3 Gene Detail
Summary
  • Symbol
    Crlf3
  • Name
    cytokine receptor-like factor 3
  • Synonyms
    Creme9, cytor4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860086
    NCBI Gene: 54394
  • Gene Overview
    MyGene.info: CRLF3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:80046493-80080991 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      34499 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.43 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CRLF3, cytokine receptor like factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRLF3, cytokine receptor like factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CREME9, CREME-9, CRLM9, CYTOR4, FRWS, p48.2
  • Links
    NCBI Gene ID: 51379
    neXtProt AC: NX_Q8IUI8
    UniProt: Q8IUI8

  • Chr Location
    17q11.2; chr17:30782684-30824760 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9327
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRLF3
  • Gene Tree
    Crlf3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    61
  • Tissues
    24
  • cDNA Data
    74
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000187 VEGA Gene Model | MGI Sequence Detail 34499 C57BL/6J ±  kb
    transcript OTTMUST00000000558 VEGA | MGI Sequence Detail 2396 Not Applicable  
    polypeptide OTTMUSP00000000242 VEGA | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      130 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 75

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144610
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 25
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory