About   Help   FAQ
Cd320
Gene Detail
 Symbol
Name
ID
Cd320
CD320 antigen
MGI:1860083
Synonyms 425O18-1, 8D6, D17Ertd716e, NG29, TCblR, VLDL
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:33843091-33849774 bp, + strand
From VEGA annotation of GRCm38

  6684 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9573  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: CD320 antigen
Gene Tree: Cd320

Human
homologs
Human Homolog CD320, CD320 molecule
NCBI Gene ID 51293
neXtProt AC  NX_Q9NPF0
Human Synonyms  8D6, 8D6A, TCBLR
Human Chr (Location)  19p13.3-p13.2; chr19:8302127-8308356 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD320
Alleles
and
phenotypes
All alleles(5) : Gene trapped(4) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
The homozygous mutant and heterozygous mice exhibited an increased mean retinal artery-to-vein ratio when compared with controls. Mice homozygous for a gene trap knock-out allele exhibit vitamin B12 deficiency in the central nervous system.
 
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process regulation of vitamin metabolic process
Component endoplasmic reticulum, extracellular vesicular exosome, ...
Function cobalamin binding, growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (36)    Tissues (14)   
Theiler Stages: 9, 15, 16, 19, 22, 24, 28
Assay TypeResults
RT-PCR 36
cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(68) Genomic(1) cDNA(64) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037211 (Evidence)
Ensembl Gene ModelENSMUSG00000002308 (Evidence)
Entrez Gene54219 (Evidence)
UniGene11175
DFCITC1577662
DoTSDT.101353920, DT.532987, DT.55209305
NIA Mouse Gene IndexU017830
Consensus CDS ProjectCCDS28632.1
International Mouse Knockout Project StatusCd320
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037211 VEGA Gene Model | MGI Sequence Detail 6684 C57BL/6J ±  kb
transcript OTTMUST00000095957 VEGA | MGI Sequence Detail 2209 Not Applicable 
polypeptide OTTMUSP00000053572 VEGA | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(10) UniProt(1)
Polymorphisms SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Protein Ontology PR:000001306 CD320 molecule
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:199961 Lai SC, et al., The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system. FASEB J. 2013 Jun;27(6):2468-75
All references(40)
Other
accession IDs
MGI:1289153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory