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Txnl1 Gene Detail
Summary
  • Symbol
    Txnl1
  • Name
    thioredoxin-like 1
  • Synonyms
    32kDa, TRP32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860078
    NCBI Gene: 53382
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:63795872-63825535 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 37.06 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860078
protein coding gene Chr18:63794165-63841872 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024499
protein coding gene Chr18:63666800-63697182 (-)
A/J MGP_AJ_G0024466
protein coding gene Chr18:60939366-60969999 (-)
AKR/J MGP_AKRJ_G0024436
protein coding gene Chr18:62637710-62669328 (-)
BALB/cJ MGP_BALBcJ_G0024465
protein coding gene Chr18:61073074-61104754 (-)
C3H/HeJ MGP_C3HHeJ_G0024233
protein coding gene Chr18:62857945-62890750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024912
protein coding gene Chr18:65393693-65426244 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022343
protein coding gene Chr18:60401407-60431626 (-)
CAST/EiJ MGP_CASTEiJ_G0023706
protein coding gene Chr18:62742278-62773456 (-)
CBA/J MGP_CBAJ_G0024203
protein coding gene Chr18:67503273-67538680 (-)
DBA/2J MGP_DBA2J_G0024333
protein coding gene Chr18:60599330-60630693 (-)
FVB/NJ MGP_FVBNJ_G0024299
protein coding gene Chr18:59980981-60010721 (-)
LP/J MGP_LPJ_G0024417
protein coding gene Chr18:63535607-63564853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024328
protein coding gene Chr18:69013335-69056912 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024959
protein coding gene Chr18:62833489-62863489 (-)
PWK/PhJ MGP_PWKPhJ_G0023449
protein coding gene Chr18:60803644-60853615 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023254
protein coding gene Chr18:63014220-63044252 (-)
WSB/EiJ MGP_WSBEiJ_G0023770
protein coding gene Chr18:62688442-62718946 (-)



Homology
more
  • Human Ortholog
    TXNL1, thioredoxin like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNL1, thioredoxin like 1
  • Synonyms
    HEL-S-114, TRP32, Txl, TXL-1, TXNL
  • Links
    NCBI Gene ID: 9352
    neXtProt AC: NX_O43396
    UniProt: O43396

  • Chr Location
    18q21.31; chr18:56597209-56651600 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53382 NCBI Gene Model | MGI Sequence Detail 29664 C57BL/6J ±  kb
    transcript NM_016792 RefSeq | MGI Sequence Detail 2558 C57BL/6  
    polypeptide Q8CDN6 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      cDNA 129
      Other 1

      Microarray probesets 8
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:62232 Lee KK, et al., Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa [published erratum appears in J Biol Chem 1998 Oct 16;273(42):27755]. J Biol Chem. 1998 Jul 24;273(30):19160-6
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory