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Msh4 Gene Detail
Summary
  • Symbol
    Msh4
  • Name
    mutS homolog 4
  • Synonyms
    4930485C04Rik, mMsh4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860077
    NCBI Gene: 55993
  • Gene Overview
    MyGene.info: MSH4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:153857149-153906138 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 78.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    428 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860077
protein coding gene Chr3:153857141-153906138 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027998
protein coding gene Chr3:157817267-157873414 (-)
A/J MGP_AJ_G0027957
protein coding gene Chr3:152073805-152123654 (-)
AKR/J MGP_AKRJ_G0027923
protein coding gene Chr3:156145652-156196914 (-)
BALB/cJ MGP_BALBcJ_G0027969
protein coding gene Chr3:151882578-151932948 (-)
C3H/HeJ MGP_C3HHeJ_G0027699
protein coding gene Chr3:156510630-156563365 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028412
protein coding gene Chr3:162956632-163015916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025750
protein coding gene Chr3:146851306-146898447 (-)
CAST/EiJ MGP_CASTEiJ_G0027152
protein coding gene Chr3:156619326-156676195 (-)
CBA/J MGP_CBAJ_G0027674
protein coding gene Chr3:168838154-168896445 (-)
DBA/2J MGP_DBA2J_G0027814
protein coding gene Chr3:151155404-151205403 (-)
FVB/NJ MGP_FVBNJ_G0027781
protein coding gene Chr3:148527911-148584412 (-)
LP/J MGP_LPJ_G0027925
protein coding gene Chr3:159146169-159202566 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027814
protein coding gene Chr3:177308365-177363597 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028471
protein coding gene Chr3:155779784-155838528 (-)
PWK/PhJ MGP_PWKPhJ_G0026875
protein coding gene Chr3:151071175-151120865 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026703
protein coding gene Chr3:153943891-153994226 (-)
WSB/EiJ MGP_WSBEiJ_G0027232
protein coding gene Chr3:156766324-156823498 (-)



Homology
more
  • Human Ortholog
    MSH4, mutS homolog 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MSH4, mutS homolog 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4438
    neXtProt AC: NX_O15457
    UniProt: O15457

  • Chr Location
    1p31.1; chr1:75796871-75913238 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1830
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MSH4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit male and female sterility associated with failure to undergo pairing during meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005493 Ensembl Gene Model | MGI Sequence Detail 48990 C57BL/6J ±  kb
    transcript ENSMUST00000005630 Ensembl | MGI Sequence Detail 3325 Not Applicable  
    polypeptide ENSMUSP00000005630 Ensembl | MGI Sequence Detail 958 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000010668 MutS protein homolog 4
    • InterPro Domains
      IPR011184 DNA mismatch repair Msh2-type
      IPR007861 DNA mismatch repair protein MutS, clamp
      IPR007860 DNA mismatch repair protein MutS, connector domain
      IPR007696 DNA mismatch repair protein MutS, core
      IPR036187 DNA mismatch repair protein MutS, core domain superfamily
      IPR000432 DNA mismatch repair protein MutS, C-terminal
      IPR017261 DNA mismatch repair protein MutS/MSH
      IPR036678 MutS, connector domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 15
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922046, MGI:2139937
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 5
    • Earliest
      J:62204 Kneitz B, et al., MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 2000 May 1;14(9):1085-97
    • Latest
      J:236226 Finsterbusch F, et al., Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. PLoS Genet. 2016 Oct;12(10):e1006393

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory