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Msh4 Gene Detail
Summary
  • Symbol
    Msh4
  • Name
    mutS homolog 4
  • Synonyms
    4930485C04Rik, mMsh4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860077
    NCBI Gene: 55993
  • Gene Overview
    MyGene.info: MSH4
Location & Maps
more
  • Sequence Map
    Chr3:153857149-153906138 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48990 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 78.70 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MSH4, mutS homolog 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MSH4, mutS homolog 4
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 4438
    neXtProt AC: NX_O15457

  • Chr Location
    1p31; chr1:75796871-75913238 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1830
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MSH4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit male and female sterility associated with failure to undergo pairing during meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047398 VEGA Gene Model | MGI Sequence Detail 48990 C57BL/6J ±  kb
transcript OTTMUST00000122429 VEGA | MGI Sequence Detail 3325 Not Applicable  
polypeptide OTTMUSP00000067162 VEGA | MGI Sequence Detail 958 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    428 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000010668 MutS protein homolog 4
  • InterPro Domains
    IPR011184 DNA mismatch repair MutS
    IPR007861 DNA mismatch repair protein MutS, clamp
    IPR007860 DNA mismatch repair protein MutS, connector domain
    IPR007696 DNA mismatch repair protein MutS, core
    IPR000432 DNA mismatch repair protein MutS, C-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 21
    cDNA 14
    Primer pair 7

    Microarray probesets 3
Other
Accession IDs
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MGI:1922046, MGI:2139937
References
more
  • Summaries
    All 39
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 5
  • Earliest
    J:62204 Kneitz B, et al., MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 2000 May 1;14(9):1085-97
  • Latest
    J:196206 Reynolds A, et al., RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nat Genet. 2013 Mar;45(3):269-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory