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Msh4
Gene Detail
Symbol

Name
ID
Msh4
mutS homolog 4 (E. coli)
MGI:1860077
Synonyms
4930485C04Rik, mMsh4
Feature Type
protein coding gene
Genetic Map
Chromosome 3
78.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:153857149-153906138 bp, - strand
From VEGA annotation of GRCm38

  48990 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MSH4
Gene Tree: Msh4

Human
homologs
MSH4, mutS homolog 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4438
neXtProt AC: NX_O15457

Human Chr (Location): 1p31; chr1:75796871-75913238 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit male and female sterility associated with failure to undergo pairing during meiosis.
 
Interactions
Msh4 interacts with 93 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process chiasma assembly, female gamete generation, ...
Component condensed chromosome, condensed nuclear chromosome, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (79)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Northern blot 16
RT-PCR 61
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase msh4    NEW 
Molecular
reagents
All nucleic(21) cDNA(14) Primer pair(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000047398 (Evidence)
Ensembl Gene Model ENSMUSG00000005493 (Evidence)
Entrez Gene 55993 (Evidence)
UniGene 272226
DFCI TC1778164, TC1605414, TC1588415, TC1587481, TC1633311
DoTS DT.94295306, DT.60106954, DT.101721265, DT.101708376, DT.101721266
Consensus CDS Project CCDS38678.1
International Mouse Phenotyping Consortium Status Msh4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047398 VEGA Gene Model | MGI Sequence Detail 48990 C57BL/6J ±  kb
transcript OTTMUST00000122429 VEGA | MGI Sequence Detail 3325 Not Applicable 
polypeptide OTTMUSP00000067162 VEGA | MGI Sequence Detail 958 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(4) UniProt(10)
Polymorphisms
SNPs within 2kb(420 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011184 DNA mismatch repair protein, MSH2
InterPro IPR007861 DNA mismatch repair protein MutS, clamp
InterPro IPR007860 DNA mismatch repair protein MutS, connector domain
InterPro IPR007696 DNA mismatch repair protein MutS, core
InterPro IPR000432 DNA mismatch repair protein MutS, C-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010668 MutS protein homolog 4
References
(Earliest) J:62204 Kneitz B, et al., MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 2000 May 1;14(9):1085-97
(Latest) J:196206 Reynolds A, et al., RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nat Genet. 2013 Mar;45(3):269-78
All references(41)
Other
accession IDs
MGI:1922046, MGI:2139937

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory