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Panx1
Gene Detail
 Symbol
Name
ID
Panx1
pannexin 1
MGI:1860055
Feature Type protein coding gene
Genetic Map
Chromosome 9
4.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:15005161-15045478 bp, - strand
From VEGA annotation of GRCm38

  40318 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Panx1

Human
homologs
Human Homolog PANX1, pannexin 1
NCBI Gene ID 24145
neXtProt AC  NX_Q96RD7
Human Synonyms  MRS1, PX1, UNQ2529
Human Chr (Location)  11q21; chr11:94128928-94185596 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired macrophage recruitment, YO-PRO-1 dye uptake, ATP release by apoptotic thymocytes, hippocampal neurons, and astrocytes. Mice homozygous for a different knock-out allele exhibit protection from I/R-induced retinal ganglion cell loss.
 
Phenotype Images(1)
Interactions
Panx1 interacts with 142 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component bleb, cell junction, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (11)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 62
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035453 (Evidence)
Ensembl Gene ModelENSMUSG00000031934 (Evidence)
Entrez Gene55991 (Evidence)
UniGene142253
DFCITC1577770
NIA Mouse Gene IndexU361085
Consensus CDS ProjectCCDS22832.1
International Mouse Knockout Project StatusPanx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035453 VEGA Gene Model | MGI Sequence Detail 40318 C57BL/6J ±  kb
transcript OTTMUST00000090718 VEGA | MGI Sequence Detail 2699 Not Applicable 
polypeptide OTTMUSP00000049806 VEGA | MGI Sequence Detail 426 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(3) UniProt(4)
Polymorphisms SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000990 Innexin
Protein Ontology PR:000012259 pannexin-1
References (Earliest) J:62853 Panchin Y, et al., A ubiquitous family of putative gap junction molecules. Curr Biol. 2000 Jun 29;10(13):R473-4
(Latest) J:210833 Penuela S, et al., Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing. J Invest Dermatol. 2014 Jul;134(7):2026-35
All references(70)
Other
accession IDs
MGI:2143143

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory