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Panx1
Gene Detail
Symbol

Name
ID
Panx1
pannexin 1
MGI:1860055
Feature Type
protein coding gene
Genetic Map
Chromosome 9
4.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:15005161-15045478 bp, - strand
From VEGA annotation of GRCm38

  40318 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PANX1
Gene Tree: Panx1

Human
homologs
PANX1, pannexin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 24145
neXtProt AC: NX_Q96RD7

Human Synonyms: MRS1, PX1, UNQ2529

Human Chr (Location): 11q21; chr11:94128928-94185596 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(1) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired macrophage recruitment, YO-PRO-1 dye uptake, ATP release by apoptotic thymocytes, hippocampal neurons, and astrocytes. Mice homozygous for a different knock-out allele exhibit protection from I/R-induced retinal ganglion cell loss.
 
Phenotype Images(1)
Interactions
Panx1 interacts with 141 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component bleb, cell junction, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (11)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 62
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase panx1 ; ZFIN panx1a, panx1b    NEW 
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035453 (Evidence)
Ensembl Gene Model ENSMUSG00000031934 (Evidence)
Entrez Gene 55991 (Evidence)
UniGene 142253
DFCI TC1577770
NIA Mouse Gene Index U361085
Consensus CDS Project CCDS22832.1
International Mouse Phenotyping Consortium Status Panx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035453 VEGA Gene Model | MGI Sequence Detail 40318 C57BL/6J ±  kb
transcript OTTMUST00000090718 VEGA | MGI Sequence Detail 2699 Not Applicable 
polypeptide OTTMUSP00000049806 VEGA | MGI Sequence Detail 426 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(3) UniProt(4)
Polymorphisms
SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000990 Innexin
Protein Ontology PR:000012259 pannexin-1
References
(Earliest) J:62853 Panchin Y, et al., A ubiquitous family of putative gap junction molecules. Curr Biol. 2000 Jun 29;10(13):R473-4
(Latest) J:220822 Gaynullina D, et al., Pannexin 1 facilitates arterial relaxation via an endothelium-derived hyperpolarization mechanism. FEBS Lett. 2015 Apr 28;589(10):1164-70
All references(77)
Other
accession IDs
MGI:2143143

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory