Panx1
Gene Detail

Symbol Name ID

Panx1 pannexin 1 MGI:1860055

Feature Type

protein coding gene

Genetic Map

Chromosome 9

4.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:15005161-15045478 bp, - strand From VEGA annotation of GRCm38   40318 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Panx1

Human homologs

Human Homolog		PANX1, pannexin 1
NCBI Gene ID		24145
neXtProt AC		NX_Q96RD7
Human Synonyms		MRS1, PX1, UNQ2529
Human Chr (Location)		11q21; chr11:93862094-93915138 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(7) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit impaired macrophage recruitment, YO-PRO-1 dye uptake, ATP release by apoptotic thymocytes, hippocampal neurons, and astrocytes.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	bleb, cell junction, ...
Function	actin binding, actin filament binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (11)    Images (20)
Theiler Stages: 23

Assay Type	Results
RNA in situ	62

cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) cDNA(58)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035453 (Evidence)
Ensembl Gene Model	ENSMUSG00000031934 (Evidence)
Entrez Gene	55991 (Evidence)
UniGene	142253
DFCI	TC1577770
NIA Mouse Gene Index	U361085
Consensus CDS Project	CCDS22832.1
International Mouse Knockout Project Status	Panx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035453	VEGA Gene Model | MGI Sequence Detail	40318	C57BL/6J
transcript	OTTMUST00000090718	VEGA | MGI Sequence Detail	2699	Not Applicable
polypeptide	OTTMUSP00000049806	VEGA | MGI Sequence Detail	426	Not Applicable

All sequences(37) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(89 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000990	Innexin
Protein Ontology	PR:000012259	pannexin-1

References

(Earliest) J:62853 Panchin Y, et al., A ubiquitous family of putative gap junction molecules. Curr Biol. 2000 Jun 29;10(13):R473-4
(Latest) J:191276 Dolmatova E, et al., Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation. Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1208-18
All references(61)

Other accession IDs

MGI:2143143