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Gene Detail
tripartite motif-containing 3
Synonyms BERP1, HAC1, Rnf22
Feature Type protein coding gene
Genetic Map
Chromosome 7
55.91 cM
Detailed Genetic Map ± 1 cM

Mapping data(1)
Sequence Map
Chr7:105604463-105633571 bp, - strand
From VEGA annotation of GRCm38

  29109 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:21290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: tripartite motif protein 2
Gene Tree: Trim3

Human Homolog TRIM3, tripartite motif containing 3
NCBI Gene ID 10612
neXtProt AC  NX_O75382
Human Synonyms  BERP, HAC1, RNF22, RNF97
Human Chr (Location)  11p15.5; chr11:6448613-6474459 (-)  GRCh38
alleles, and
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a null allele have decreased susceptibility to pharmacologically induced seizure as well as reduced miniature inhibitory synaptic current amplitude in cortical neurons. Mice homozygous for another null allele are viable and fertile.
Trim3 interacts with 171 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
All GO classifications: (11 annotations)
Process protein transport, protein ubiquitination, ...
Component cytoplasm, endosome, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Literature Summary: (2 records)
Data Summary: Results (91)    Tissues (61)    Images (9)
Theiler Stages: 17, 18, 21, 23, 27, 28
Assay TypeResults
RNA in situ 91
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(54) cDNA(54)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000017539 (Evidence)
Ensembl Gene ModelENSMUSG00000036989 (Evidence)
Entrez Gene55992 (Evidence)
DFCITC1579277, TC1724572
DoTSDT.101209771, DT.101377485, DT.94198792, DT.99845361
NIA Mouse Gene IndexU029040
Consensus CDS ProjectCCDS21655.1, CCDS72012.1
International Mouse Knockout Project StatusTrim3
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017539 VEGA Gene Model | MGI Sequence Detail 29109 C57BL/6J ±  kb
transcript OTTMUST00000042620 VEGA | MGI Sequence Detail 3016 Not Applicable 
polypeptide OTTMUSP00000019153 VEGA | MGI Sequence Detail 744 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(18) UniProt(4)
Polymorphisms SNPs within 2kb(194 from dbSNP Build 137)
InterPro IPR003649 B-box, C-terminal
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR001258 NHL repeat
InterPro IPR013017 NHL repeat, subgroup
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR000315 Zinc finger, B-box
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000029826 tripartite motif-containing protein 3
References (Earliest) J:63920 Arama E, et al., Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain. Oncogene. 2000 Aug 3;19(33):3706-16
(Latest) J:209460 Raheja R, et al., The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. Biochem J. 2014 Mar 15;458(3):537-45
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory