About   Help   FAQ
Hes6
Gene Detail
Symbol

Name
ID
Hes6
hairy and enhancer of split 6
MGI:1859852
Synonyms
bHLHb41
Feature Type
protein coding gene
Genetic Map
Chromosome 1
46.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:91411483-91414038 bp, - strand
From VEGA annotation of GRCm38

  2556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23111  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Hes6

Human
homologs
Human Homolog HES6, hes family bHLH transcription factor 6
NCBI Gene ID 55502
neXtProt AC  NX_Q96HZ4
Human Synonyms  bHLHb41, bHLHc23, C-HAIRY1, HES-6
Human Chr (Location)  2q37.3; chr2:238238267-238240124 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hes6 interacts with 54 markers (Mir18, Mir22, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus, transcription factor complex
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (625)    Tissues (357)    Images (140)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 596
Northern blot 18
Western blot 3
RT-PCR 8
cDNA source data(78)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) cDNA(80) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020919 (Evidence)
Ensembl Gene ModelENSMUSG00000067071 (Evidence)
Entrez Gene55927 (Evidence)
UniGene280029
DFCITC1576125, TC1607383
DoTSDT.101272261, DT.94355115
NIA Mouse Gene IndexU021592
Consensus CDS ProjectCCDS15163.1
International Mouse Knockout Project StatusHes6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020919 VEGA Gene Model | MGI Sequence Detail 2556 C57BL/6J ±  kb
transcript OTTMUST00000049445 VEGA | MGI Sequence Detail 1335 Not Applicable 
polypeptide OTTMUSP00000022914 VEGA | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
Protein Ontology PR:000008520 transcription cofactor HES-6
References
(Earliest) J:62626 Bae S, et al., The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development. 2000 Jul;127(13):2933-43
(Latest) J:193574 Wickramasinghe CM, et al., HES6 enhances the motility of alveolar rhabdomyosarcoma cells. Exp Cell Res. 2013 Jan 1;319(1):103-12
All references(71)
Other
accession IDs
MGI:2138216

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory