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Hes6 Gene Detail
Summary
  • Symbol
    Hes6
  • Name
    hairy and enhancer of split 6
  • Synonyms
    bHLHb41
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859852
    NCBI Gene: 55927
  • Gene Overview
    MyGene.info: HES6
Location & Maps
more
  • Sequence Map
    Chr1:91411483-91414038 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2556 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 46.12 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HES6, hes family bHLH transcription factor 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HES6, hes family bHLH transcription factor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHb41, bHLHc23, C-HAIRY1, HES-6
  • Links
    NCBI Gene ID: 55502
    neXtProt AC: NX_Q96HZ4

  • Chr Location
    2q37.3; chr2:238238267-238240124 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Hes6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020919 VEGA Gene Model | MGI Sequence Detail 2556 C57BL/6J ±  kb
transcript OTTMUST00000049445 VEGA | MGI Sequence Detail 1335 Not Applicable  
polypeptide OTTMUSP00000022914 VEGA | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008520 transcription cofactor HES-6
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003650 Orange domain
Molecular
Reagents
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  • All nucleic 84
    cDNA 80
    Primer pair 2
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGI:2138216
References
more
  • Summaries
    All 71
    Developmental Gene Expression 39
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:62626 Bae S, et al., The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development. 2000 Jul;127(13):2933-43
  • Latest
    J:227000 Hsu LC, et al., Lhx2 regulates the timing of beta-catenin-dependent cortical neurogenesis. Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12199-204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory