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Fezf2
Gene Detail
Symbol

Name
ID
Fezf2
Fez family zinc finger 2
MGI:1859823
Synonyms
Fez, Fezl, forebrain embryonic zinc finger, Zfp312
Feature Type
protein coding gene
Genetic Map
Chromosome 14
6.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:12341892-12345865 bp, - strand
From NCBI annotation of GRCm38

  3974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fezf2

Human
homologs
Human Homolog FEZF2, FEZ family zinc finger 2
NCBI Gene ID 55079
neXtProt AC  NX_Q8TBJ5
Human Synonyms  FEZ, FEZL, TOF, ZFP312, ZNF312
Human Chr (Location)  3p14.2; chr3:62369672-62373515 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show hyperactivity, altered feeding behavior leading to delayed growth and premature death, and impaired formation of subplate neurons and thalamocortical projections. Homozygotes for another allele lack a corpus callosum and show severe subcortical projection defects.
 
Phenotype Images(1)
Interactions
Fezf2 interacts with 100 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process axonal fasciculation, axon guidance, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (222)    Tissues (141)    Images (67)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 206
Northern blot 14
RT-PCR 2
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021743 (Evidence)
Entrez Gene54713 (Evidence)
UniGene34644
DFCITC1582309, TC1589806, TC1679102
DoTSDT.101318356, DT.526706, DT.94266173
NIA Mouse Gene IndexU035239
Consensus CDS ProjectCCDS26818.1
International Mouse Knockout Project StatusFezf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 54713 NCBI Gene Model | MGI Sequence Detail 3974 C57BL/6J ±  kb
transcript NM_080433 RefSeq | MGI Sequence Detail 2304 C57BL/6 
polypeptide Q9ESP5 UniProt | EBI | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000007469 fez family zinc finger protein 2
Graphical View of Protein Domain Structure
References
(Earliest) J:62051 Matsuo-Takasaki M, et al., Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mech Dev. 2000 May;93(1-2):201-4
(Latest) J:206763 Gan Q, et al., Pax6 mediates ss-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells. 2014 Jan;32(1):45-58
All references(79)
Other
accession IDs
MGI:2145654, MGI:2145702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory