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Fezf2 Gene Detail
Summary
  • Symbol
    Fezf2
  • Name
    Fez family zinc finger 2
  • Synonyms
    Fez, Fezl, forebrain embryonic zinc finger, Zfp312
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859823
    NCBI Gene: 54713
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:12341892-12345865 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3974 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 6.36 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FEZF2, FEZ family zinc finger 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FEZF2, FEZ family zinc finger 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FEZ, FEZL, FKSG36, TOF, ZFP312, ZNF312
  • Links
    NCBI Gene ID: 55079
    neXtProt AC: NX_Q8TBJ5
    UniProt: Q8TBJ5

  • Chr Location
    3p14.2; chr3:62369672-62373515 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9957
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FEZF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 5 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show hyperactivity, altered feeding behavior leading to delayed growth and premature death, and impaired formation of subplate neurons and thalamocortical projections. Homozygotes for another allele lack a corpus callosum and show severe subcortical projection defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54713 NCBI Gene Model | MGI Sequence Detail 3974 C57BL/6J ±  kb
    transcript NM_080433 RefSeq | MGI Sequence Detail 2304 C57BL/6  
    polypeptide Q9ESP5 UniProt | EBI | MGI Sequence Detail 455 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      34 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145654, MGI:2145702
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 66
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:62051 Matsuo-Takasaki M, et al., Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mech Dev. 2000 May;93(1-2):201-4
    • Latest
      J:244825 Dennis DJ, et al., Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4934-E4943

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory