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Fezf2 Gene Detail
Summary
  • Symbol
    Fezf2
  • Name
    Fez family zinc finger 2
  • Synonyms
    Fez, Fezl, forebrain embryonic zinc finger, Zfp312
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859823
    NCBI Gene: 54713
Location & Maps
more
  • Sequence Map
    Chr14:12341892-12345865 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3974 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 6.36 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FEZF2, FEZ family zinc finger 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FEZF2, FEZ family zinc finger 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FEZ, FEZL, FKSG36, TOF, ZFP312, ZNF312
  • Links
    NCBI Gene ID: 55079
    neXtProt AC: NX_Q8TBJ5

  • Chr Location
    3p14.2; chr3:62369672-62373515 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9957
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FEZF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 5 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    1
  • Targeted
    5
  • Transgenic
    2
  • Incidental Mutations
Homozygotes for a null allele show hyperactivity, altered feeding behavior leading to delayed growth and premature death, and impaired formation of subplate neurons and thalamocortical projections. Homozygotes for another allele lack a corpus callosum and show severe subcortical projection defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54713 NCBI Gene Model | MGI Sequence Detail 3974 C57BL/6J ±  kb
transcript NM_080433 RefSeq | MGI Sequence Detail 2304 C57BL/6  
polypeptide Q9ESP5 UniProt | EBI | MGI Sequence Detail 455 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    34 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007469 fez family zinc finger protein 2
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 23
    cDNA 20
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGI:2145654, MGI:2145702
References
more
  • Summaries
    All 84
    Developmental Gene Expression 52
    Gene Ontology 10
    Phenotypes 19
  • Earliest
    J:62051 Matsuo-Takasaki M, et al., Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mech Dev. 2000 May;93(1-2):201-4
  • Latest
    J:228034 Takaba H, et al., Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. Cell. 2015 Nov 5;163(4):975-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory