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Fezf2
Gene Detail
Symbol

Name
ID
Fezf2
Fez family zinc finger 2
MGI:1859823
Synonyms
Fez, Fezl, forebrain embryonic zinc finger, Zfp312
Feature Type
protein coding gene
Genetic Map
Chromosome 14
6.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:12341892-12345865 bp, - strand
From NCBI annotation of GRCm38

  3974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FEZF2
Gene Tree: Fezf2

Human
homologs
FEZF2, FEZ family zinc finger 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55079
neXtProt AC: NX_Q8TBJ5

Human Synonyms: FEZ, FEZL, FKSG36, TOF, ZFP312, ZNF312

Human Chr (Location): 3p14.2; chr3:62369672-62373515 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a null allele show hyperactivity, altered feeding behavior leading to delayed growth and premature death, and impaired formation of subplate neurons and thalamocortical projections. Homozygotes for another allele lack a corpus callosum and show severe subcortical projection defects.
 
Phenotype Images(1)
Interactions
Fezf2 interacts with 100 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process axonal fasciculation, axon guidance, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (230)    Tissues (146)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 214
Northern blot 14
RT-PCR 2
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase fezf2 ; ZFIN fezf2    NEW 
Molecular
reagents
All nucleic(22) cDNA(20) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021743 (Evidence)
Entrez Gene 54713 (Evidence)
UniGene 34644
DFCI TC1679102, TC1589806, TC1582309
DoTS DT.94266173, DT.526706, DT.101318356
NIA Mouse Gene Index U035239
Consensus CDS Project CCDS26818.1
International Mouse Phenotyping Consortium Status Fezf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 54713 NCBI Gene Model | MGI Sequence Detail 3974 C57BL/6J ±  kb
transcript NM_080433 RefSeq | MGI Sequence Detail 2304 C57BL/6 
polypeptide Q9ESP5 UniProt | EBI | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000007469 fez family zinc finger protein 2
Graphical View of Protein Domain Structure
References
(Earliest) J:62051 Matsuo-Takasaki M, et al., Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mech Dev. 2000 May;93(1-2):201-4
(Latest) J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
All references(82)
Other
accession IDs
MGI:2145654, MGI:2145702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory