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Prdx4 Gene Detail
Summary
  • Symbol
    Prdx4
  • Name
    peroxiredoxin 4
  • Synonyms
    AOE372, Prx4, Prx-iv, Prx IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859815
    NCBI Gene: 53381
  • Gene Overview
    MyGene.info: PRDX4
Location & Maps
more
  • Sequence Map
    ChrX:155323918-155340754 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16837 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 72.38 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRDX4, peroxiredoxin 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRDX4, peroxiredoxin 4
    Orthology source: HomoloGene
  • Synonyms
    AOE372, AOE37-2, HEL-S-97n, PRX-4
  • Links
    NCBI Gene ID: 10549
    neXtProt AC: NX_Q13162

  • Chr Location
    Xp22.11; chrX:23664260-23686399 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4672
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PRDX4
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
Mice homozygous for a null allele exhibit decreased testicular weight, testis atrophy, and oligozoospermia due to increased apoptosis associated with oxidative damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019347 VEGA Gene Model | MGI Sequence Detail 16837 C57BL/6J ±  kb
transcript OTTMUST00000046190 VEGA | MGI Sequence Detail 990 Not Applicable  
polypeptide OTTMUSP00000020870 VEGA | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    77 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 127
    cDNA 126
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 41
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:58337 Lee TH, et al., Characterization of mouse peroxiredoxin I genomic DNA and its expression. Gene. 1999 Nov 1;239(2):243-50
  • Latest
    J:227089 Pirson M, et al., Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development. J Comp Neurol. 2015 Dec 1;523(17):2599-617

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory