Prdx4 MGI Mouse Gene Detail - MGI:1859815

Symbol

Prdx4
Name

peroxiredoxin 4
Synonyms

AOE372, Prx4, Prx-iv, Prx IV

Feature Type

protein coding gene
IDs

MGI:1859815
NCBI Gene: 53381
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:154106914-154123750 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 72.38 cM
Mapping Data

2 experiments

SNPs within 2kb

77 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859815	protein coding gene	ChrX:154106914-154125268 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036213	protein coding gene	ChrX:153220173-153238311 (-)
A/J	MGP_AJ_G0036183	protein coding gene	ChrX:152493096-152510101 (-)
AKR/J	MGP_AKRJ_G0036111	protein coding gene	ChrX:157320464-157338834 (-)
BALB/cJ	MGP_BALBcJ_G0036176	protein coding gene	ChrX:150601864-150619499 (-)
C3H/HeJ	MGP_C3HHeJ_G0035882	protein coding gene	ChrX:153546944-153563780 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036698	protein coding gene	ChrX:157678385-157695766 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033519	protein coding gene	ChrX:144066867-144082559 (-)
CAST/EiJ	MGP_CASTEiJ_G0035170	protein coding gene	ChrX:132712481-132729844 (-)
CBA/J	MGP_CBAJ_G0035857	protein coding gene	ChrX:162177509-162194365 (-)
DBA/2J	MGP_DBA2J_G0036023	protein coding gene	ChrX:151497265-151515156 (-)
FVB/NJ	MGP_FVBNJ_G0035953	protein coding gene	ChrX:150606451-150622585 (-)
LP/J	MGP_LPJ_G0036108	protein coding gene	ChrX:154315766-154332534 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035986	protein coding gene	ChrX:170530722-170550561 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036739	protein coding gene	ChrX:152789447-152807898 (-)
PWK/PhJ	MGP_PWKPhJ_G0034868	protein coding gene	ChrX:129698064-129715357 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034689	protein coding gene	ChrX:133165121-133181828 (-)
WSB/EiJ	MGP_WSBEiJ_G0035305	protein coding gene	ChrX:150789058-150805929 (-)

Human Ortholog

PRDX4, peroxiredoxin 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRDX4, peroxiredoxin 4
Synonyms

AOE372, AOE37-2, HEL-S-97n, PRX-4
Links

HGNC:17169

NCBI Gene ID: 10549

neXtProt AC: NX_Q13162

UniProt: Q13162
Chr Location

Xp22.11; chrX:23664262-23686397 (+) GRCh38

MGI Vertebrate Homology

Prdx4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRDX4
Gene Tree

Prdx4

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

6
Gene trapped

1
Targeted

6
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased testicular weight, testis atrophy, and oligozoospermia due to increased apoptosis associated with oxidative damage.

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All GO Annotations

37
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

17
cDNA Data

126
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prdx4

ZFIN prdx4

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All Sequences

52
RefSeq

6
UniProt

3
CCDS

CCDS30496.1

Ensembl

ENSMUSG00000025289 (Evidence)
NCBI Gene

53381

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025289	Ensembl Gene Model \| MGI Sequence Detail	16837	C57BL/6J	± kb
transcript	ENSMUST00000026328	Ensembl \| MGI Sequence Detail	990	Not Applicable
polypeptide	ENSMUSP00000026328	Ensembl \| MGI Sequence Detail	274	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013194 peroxiredoxin-4

(term hierarchy)
PDB

3VWU, 3VWV, 3W8J, 3WGX
EC

1.11.1.24
InterPro Domains

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant

IPR019479 Peroxiredoxin, C-terminal

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily

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All nucleic 129

cDNA 128

Primer pair 1

Microarray probesets 6

Summaries

All 60

Developmental Gene Expression 9

Gene Ontology 13

Phenotypes 17
Earliest

J:58337 Lee TH, et al., Characterization of mouse peroxiredoxin I genomic DNA and its expression. Gene. 1999 Nov 1;239(2):243-50
Latest

J:326889 Homma T, et al., Consequences of a peroxiredoxin 4 (Prdx4) deficiency on learning and memory in mice. Biochem Biophys Res Commun. 2022 Jul 3;621:32-38

TSS for Prdx4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164441	ChrX:154123764-154123769 (-)	-17 bp
Tssr164440	ChrX:154123743-154123755 (-)	1 bp
Tssr164439	ChrX:154121471-154121482 (-)	2,273 bp
Tssr164438	ChrX:154121456-154121467 (-)	2,288 bp
Tssr164437	ChrX:154121385-154121452 (-)	2,331 bp
Tssr164436	ChrX:154121372-154121383 (-)	2,372 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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