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Prdx4 Gene Detail
Summary
  • Symbol
    Prdx4
  • Name
    peroxiredoxin 4
  • Synonyms
    AOE372, Prx4, Prx-iv, Prx IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859815
    NCBI Gene: 53381
  • Gene Overview
    MyGene.info: PRDX4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:155323918-155340749 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 72.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859815
protein coding gene ChrX:155323918-155340754 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036213
protein coding gene ChrX:153220173-153238311 (-)
A/J MGP_AJ_G0036183
protein coding gene ChrX:152493096-152510101 (-)
AKR/J MGP_AKRJ_G0036111
protein coding gene ChrX:157320464-157338834 (-)
BALB/cJ MGP_BALBcJ_G0036176
protein coding gene ChrX:150601864-150619499 (-)
C3H/HeJ MGP_C3HHeJ_G0035882
protein coding gene ChrX:153546944-153563780 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036698
protein coding gene ChrX:157678385-157695766 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033519
protein coding gene ChrX:144066867-144082559 (-)
CAST/EiJ MGP_CASTEiJ_G0035170
protein coding gene ChrX:132712481-132729844 (-)
CBA/J MGP_CBAJ_G0035857
protein coding gene ChrX:162177509-162194365 (-)
DBA/2J MGP_DBA2J_G0036023
protein coding gene ChrX:151497265-151515156 (-)
FVB/NJ MGP_FVBNJ_G0035953
protein coding gene ChrX:150606451-150622585 (-)
LP/J MGP_LPJ_G0036108
protein coding gene ChrX:154315766-154332534 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035986
protein coding gene ChrX:170530722-170550561 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036739
protein coding gene ChrX:152789447-152807898 (-)
PWK/PhJ MGP_PWKPhJ_G0034868
protein coding gene ChrX:129698064-129715357 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034689
protein coding gene ChrX:133165121-133181828 (-)
WSB/EiJ MGP_WSBEiJ_G0035305
protein coding gene ChrX:150789058-150805929 (-)



Homology
more
  • Human Ortholog
    PRDX4, peroxiredoxin 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRDX4, peroxiredoxin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AOE372, AOE37-2, HEL-S-97n, PRX-4
  • Links
    NCBI Gene ID: 10549
    neXtProt AC: NX_Q13162
    UniProt: Q13162

  • Chr Location
    Xp22.11; chrX:23664260-23686399 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4672
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRDX4
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased testicular weight, testis atrophy, and oligozoospermia due to increased apoptosis associated with oxidative damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53381 NCBI Gene Model | MGI Sequence Detail 16832 C57BL/6J ±  kb
    transcript NM_016764 RefSeq | MGI Sequence Detail 999 C57BL/6  
    polypeptide O08807 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 129
      cDNA 128
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 9
    • Earliest
      J:58337 Lee TH, et al., Characterization of mouse peroxiredoxin I genomic DNA and its expression. Gene. 1999 Nov 1;239(2):243-50
    • Latest
      J:249157 Nawata A, et al., Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease. PLoS One. 2016;11(4):e0152549

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory