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Hif3a
Gene Detail
Symbol

Name
ID
Hif3a
hypoxia inducible factor 3, alpha subunit
MGI:1859778
Synonyms
bHLHe17, MOP7, Nepas
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.15 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:17031507-17062427 bp, - strand
From VEGA annotation of GRCm38

  30921 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Hif3a

Human
homologs
Human Homolog HIF3A, hypoxia inducible factor 3, alpha subunit
NCBI Gene ID 64344
neXtProt AC  NX_Q9Y2N7
Human Synonyms  bHLHe17, HIF-3A, IPAS, MOP7, PASD7
Human Chr (Location)  19q13.32; chr19:46297046-46343433 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display impaired lung remodeling resulting in hypertrophy of the heart right ventricle and pulmonary hyperplasia.
 
Interactions
Hif3a interacts with 376 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (73)    Tissues (52)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000022817 (Evidence)
Ensembl Gene ModelENSMUSG00000004328 (Evidence)
Entrez Gene53417 (Evidence)
UniGene135110
DFCITC1592082, TC1671275, TC1590314
DoTSDT.110980637, DT.94222116, DT.40136353
NIA Mouse Gene IndexU028197
Consensus CDS ProjectCCDS20860.1, CCDS52045.1
International Mouse Knockout Project StatusHif3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022817 VEGA Gene Model | MGI Sequence Detail 30921 C57BL/6J ±  kb
transcript OTTMUST00000054840 VEGA | MGI Sequence Detail 6402 Not Applicable 
polypeptide OTTMUSP00000026203 VEGA | MGI Sequence Detail 664 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021537 Hypoxia-inducible factor, alpha subunit
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000008557 hypoxia-inducible factor 3-alpha
References
(Earliest) J:62516 Gu YZ, et al., Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr. 1998;7(3):205-13
(Latest) J:198291 Huang Y, et al., Hypoxia inducible factor 3alpha plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS One. 2013;8(2):e57695
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory