Rgs14
Gene Detail

Symbol Name ID

Rgs14 regulator of G-protein signaling 14 MGI:1859709

Synonyms

Rap1/rap2 interacting protein

Feature Type

protein coding gene

Genetic Map

Chromosome 13

29.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:55369732-55384687 bp, + strand From VEGA annotation of GRCm38   14956 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: regulator of G protein signaling, RGS12/RGS14 types
Gene Tree: Rgs14

Human homologs

Human Homolog		RGS14, regulator of G-protein signaling 14
NCBI Gene ID		10636
neXtProt AC		NX_O43566
Human Chr (Location)		5q35.3; chr5:176784844-176799599 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous mutation of this gene with one allele results in failure to complete the first zygotic cell division. Homozygous mutation of this gene with a second allele results in no obvious phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	cell cycle, cell division, ...
Component	cell junction, cell projection, ...
Function	GDP-dissociation inhibitor activity, G-protein alpha-subunit binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (28)    Tissues (19)    Images (4)
Theiler Stages: 11, 15, 23, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	24

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033508 (Evidence)
Ensembl Gene Model	ENSMUSG00000052087 (Evidence)
Entrez Gene	51791 (Evidence)
UniGene	1426
DFCI	TC1583889
DoTS	DT.101356260, DT.40167307, DT.91313874
NIA Mouse Gene Index	U014885
PDB	1WFY
Consensus CDS Project	CCDS36674.1
International Mouse Knockout Project Status	Rgs14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033508	VEGA Gene Model | MGI Sequence Detail	14956	C57BL/6J
transcript	OTTMUST00000084287	VEGA | MGI Sequence Detail	2356	Not Applicable
polypeptide	OTTMUSP00000045408	VEGA | MGI Sequence Detail	547	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(72 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003109	GoLoco motif
InterPro	IPR003116	Raf-like Ras-binding
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013949	regulator of G-protein signaling 14

References

(Earliest) J:172908 Traver S, et al., RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochem J. 2000 Aug 15;350 Pt 1:19-29
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(43)