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Rgs14
Gene Detail
Symbol

Name
ID
Rgs14
regulator of G-protein signaling 14
MGI:1859709
Synonyms
Rap1/rap2 interacting protein
Feature Type
protein coding gene
Genetic Map
Chromosome 13
29.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:55369732-55384687 bp, + strand
From VEGA annotation of GRCm38

  14956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: RGS14
Protein SuperFamily: regulator of G protein signaling, RGS12/RGS14 types
Gene Tree: Rgs14

Human
homologs
RGS14, regulator of G-protein signaling 14
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10636
neXtProt AC: NX_O43566

Human Chr (Location): 5q35.3; chr5:177357711-177372601 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Genomic Mutations involving Rgs14 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene with one allele results in failure to complete the first zygotic cell division. Homozygous mutation of this gene with a second allele results in no obvious phenotype.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Rgs14 interacts with 101 markers (Mir7-2, Mir7b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process cell cycle, cell division, ...
Component cell junction, cell projection, ...
Function GDP-dissociation inhibitor activity, G-protein alpha-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (28)    Tissues (19)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 24
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rgs14 ; ZFIN rgs14a    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033508 (Evidence)
Ensembl Gene Model ENSMUSG00000052087 (Evidence)
Entrez Gene 51791 (Evidence)
UniGene 1426
DFCI TC1583889
DoTS DT.101356260, DT.40167307, DT.91313874
NIA Mouse Gene Index U014885
PDB 1WFY
Consensus CDS Project CCDS36674.1
International Mouse Phenotyping Consortium Status Rgs14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033508 VEGA Gene Model | MGI Sequence Detail 14956 C57BL/6J ±  kb
transcript OTTMUST00000084287 VEGA | MGI Sequence Detail 2356 Not Applicable 
polypeptide OTTMUSP00000045408 VEGA | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003109 GoLoco motif
InterPro IPR003116 Raf-like Ras-binding
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013949 regulator of G-protein signaling 14
References
(Earliest) J:172908 Traver S, et al., RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochem J. 2000 Aug 15;350 Pt 1:19-29
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory