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Mtx2 Gene Detail
Summary
  • Symbol
    Mtx2
  • Name
    metaxin 2
  • Synonyms
    1500012G02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859652
    NCBI Gene: 53375
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74825812-74876748 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859652
protein coding gene Chr2:74825803-74878431 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025855
protein coding gene Chr2:75151411-75208464 (+)
A/J MGP_AJ_G0025833
protein coding gene Chr2:72206515-72259206 (+)
AKR/J MGP_AKRJ_G0025801
protein coding gene Chr2:74166196-74219653 (+)
BALB/cJ MGP_BALBcJ_G0025827
protein coding gene Chr2:72395826-72449578 (+)
C3H/HeJ MGP_C3HHeJ_G0025587
protein coding gene Chr2:74359105-74414122 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026274
protein coding gene Chr2:77393710-77451852 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023677
protein coding gene Chr2:69632888-69687852 (+)
CAST/EiJ MGP_CASTEiJ_G0025051
protein coding gene Chr2:74679620-74739325 (+)
CBA/J MGP_CBAJ_G0025568
protein coding gene Chr2:80226304-80282524 (+)
DBA/2J MGP_DBA2J_G0025699
protein coding gene Chr2:71818034-71870668 (+)
FVB/NJ MGP_FVBNJ_G0025661
protein coding gene Chr2:71204148-71257914 (+)
LP/J MGP_LPJ_G0025787
protein coding gene Chr2:75010638-75063362 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025692
protein coding gene Chr2:82119232-82201615 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026331
protein coding gene Chr2:74285123-74339344 (+)
PWK/PhJ MGP_PWKPhJ_G0024792
protein coding gene Chr2:71747768-71803099 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024600
protein coding gene Chr2:74516511-74571263 (+)
WSB/EiJ MGP_WSBEiJ_G0025119
protein coding gene Chr2:74725460-74782670 (+)



Homology
more
  • Human Ortholog
    MTX2, metaxin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MTX2, metaxin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10651
    neXtProt AC: NX_O75431
    UniProt: O75431

  • Chr Location
    2q31.1; chr2:176269395-176338025 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4777
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MTX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 53375 NCBI Gene Model | MGI Sequence Detail 50937 C57BL/6J ±  kb
transcript NM_016804 RefSeq | MGI Sequence Detail 1258 C57BL/6  
polypeptide O88441 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010756 metaxin-2
  • InterPro Domains
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR040079 Glutathione Transferase family
    IPR033468 Metaxin, glutathione S-transferase domain
    IPR019564 Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916200
References
more
  • Summaries
    All 50
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:10491 Davisson MT, et al., The mouse mutation ulnaless on chromosome 2. J Hered. 1990 Mar-Apr;81(2):151-3
  • Latest
    J:268053 Yakushiji-Kaminatsui N, et al., Similarities and differences in the regulation of HoxD genes during chick and mouse limb development. PLoS Biol. 2018 Nov;16(11):e3000004

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory