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Ramp2 Gene Detail
Summary
  • Symbol
    Ramp2
  • Name
    receptor (calcitonin) activity modifying protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859650
    NCBI Gene: 54409
  • Gene Overview
    MyGene.info: RAMP2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:101246028-101259546 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      13519 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.47 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAMP2, receptor activity modifying protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RAMP2, receptor activity modifying protein 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 10266
    neXtProt AC: NX_O60895
    UniProt: O60895

  • Chr Location
    17q21.2; chr17:42761194-42763041 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    4 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality. Mice heterozygous for the null allele exhibit decreased litter size beyond the loss of homozygous embryos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    31
  • Tissues
    23
  • cDNA Data
    11
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002758 VEGA Gene Model | MGI Sequence Detail 13519 C57BL/6J ±  kb
    transcript OTTMUST00000005496 VEGA | MGI Sequence Detail 1178 Not Applicable  
    polypeptide OTTMUSP00000002615 VEGA | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      27 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:246716 Xian X, et al., Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells. Endocrinology. 2017 May 01;158(5):1359-1372
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory