Ramp2
Gene Detail

Symbol Name ID

Ramp2 receptor (calcitonin) activity modifying protein 2 MGI:1859650

Feature Type

protein coding gene

Genetic Map

Chromosome 11

64.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:101246028-101259546 bp, + strand From VEGA annotation of GRCm38   13519 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Ramp2

Human homologs

Human Homolog		RAMP2, receptor (G protein-coupled) activity modifying protein 2
NCBI Gene ID		10266
neXtProt AC		NX_O60895
Human Chr (Location)		17q12-q21.1; chr17:42761194-42763041 (+)  GRCh38

Alleles and phenotypes

All alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 

Mice homozygous for a null allele exhibit embryonic lethality. Mice heterozygous for the null allele exhibit decreased litter size beyond the loss of homozygous embryos.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	adherens junction assembly, angiogenesis, ...
Component	cell surface, cytoplasm, ...
Function	coreceptor activity, protein transporter activity

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (15)    Tissues (15)    Images (1)
Theiler Stages: 26, 28

Assay Type	Results
Northern blot	12
RT-PCR	3

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000002758 (Evidence)
Ensembl Gene Model	ENSMUSG00000001240 (Evidence)
Entrez Gene	54409 (Evidence)
DFCI	TC1574909, TC1699408
Consensus CDS Project	CCDS25457.1
International Mouse Knockout Project Status	Ramp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002758	VEGA Gene Model | MGI Sequence Detail	13519	C57BL/6J
transcript	OTTMUST00000005496	VEGA | MGI Sequence Detail	1178	Not Applicable
polypeptide	OTTMUSP00000002615	VEGA | MGI Sequence Detail	189	Not Applicable

All sequences(53) RefSeq(2) UniProt(6)

Polymorphisms

SNPs within 2kb(28 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR006985	Receptor activity modifying protein
Protein Ontology	PR:000013706	receptor activity-modifying protein 2

References

(Earliest) J:61899 Ono Y, et al., Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem Biophys Res Commun. 2000 Apr 29;271(1):197-202
(Latest) J:210427 Koyama T, et al., Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis. Circulation. 2013 Feb 19;127(7):842-53
All references(42)