Ramp2
Gene Detail

Symbol

Name
ID

Ramp2
receptor (calcitonin) activity modifying protein 2
MGI:1859650

Feature Type

protein coding gene

Genetic Map

Chromosome 11
64.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:101246028-101259546 bp, + strand From VEGA annotation of GRCm38   13519 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Ramp2

Human
homologs

Human Homolog		RAMP2, receptor (G protein-coupled) activity modifying protein 2
NCBI Gene ID		10266
neXtProt AC		NX_O60895
Human Chr (Location)		17q12-q21.1; chr17:42761194-42763041 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Genomic Mutations involving Ramp2 (1)
Incidental mutations (data from APF )
 

Mice homozygous for a null allele exhibit embryonic lethality. Mice heterozygous for the null allele exhibit decreased litter size beyond the loss of homozygous embryos.

 
Phenotype Images(4)

Interactions

Ramp2 interacts with 218 markers (Mir10a, Mir10b, Mir15a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (42 annotations)

Process	adherens junction assembly, angiogenesis, ...
Component	cell surface, cytoplasm, ...
Function	coreceptor activity, protein transporter activity

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (15)    Tissues (15)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
Northern blot	12
RT-PCR	3

cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(16) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000002758 (Evidence)
Ensembl Gene Model	ENSMUSG00000001240 (Evidence)
Entrez Gene	54409 (Evidence)
DFCI	TC1699408, TC1574909
Consensus CDS Project	CCDS25457.1
International Mouse Knockout Project Status	Ramp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002758	VEGA Gene Model | MGI Sequence Detail	13519	C57BL/6J
transcript	OTTMUST00000005496	VEGA | MGI Sequence Detail	1178	Not Applicable
polypeptide	OTTMUSP00000002615	VEGA | MGI Sequence Detail	189	Not Applicable

All sequences(53) RefSeq(2) UniProt(6)

Polymorphisms

SNPs within 2kb(28 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR006985	Receptor activity modifying protein
Protein Ontology	PR:000013706	receptor activity-modifying protein 2

References

(Earliest) J:61899 Ono Y, et al., Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem Biophys Res Commun. 2000 Apr 29;271(1):197-202
(Latest) J:212965 Uetake R, et al., Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection. PLoS One. 2014;9(2):e87667
All references(43)