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Ramp2 Gene Detail
Summary
  • Symbol
    Ramp2
  • Name
    receptor (calcitonin) activity modifying protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859650
    NCBI Gene: 54409
  • Gene Overview
    MyGene.info: RAMP2
Location & Maps
more
  • Sequence Map
    Chr11:101246028-101259546 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13519 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.47 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAMP2, receptor activity modifying protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RAMP2, receptor activity modifying protein 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 10266
    neXtProt AC: NX_O60895

  • Chr Location
    17q12-q21.1; chr17:42761194-42763041 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    4 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    3
  • Targeted
    6
  • Genomic Mutations
    1 involving Ramp2
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit embryonic lethality. Mice heterozygous for the null allele exhibit decreased litter size beyond the loss of homozygous embryos.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002758 VEGA Gene Model | MGI Sequence Detail 13519 C57BL/6J ±  kb
transcript OTTMUST00000005496 VEGA | MGI Sequence Detail 1178 Not Applicable  
polypeptide OTTMUSP00000002615 VEGA | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013706 receptor activity-modifying protein 2
  • InterPro Domains
    IPR006985 Receptor activity modifying protein
Molecular
Reagents
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  • All nucleic 16
    cDNA 14
    Primer pair 1
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 42
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:61899 Ono Y, et al., Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem Biophys Res Commun. 2000 Apr 29;271(1):197-202
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory