Ramp2 MGI Mouse Gene Detail - MGI:1859650 - receptor (calcitonin) activity modifying protein 2

Ramp2 Gene Detail

Symbol

Ramp2
Name

receptor (calcitonin) activity modifying protein 2

Feature Type

protein coding gene
IDs

MGI:1859650
NCBI Gene: 54409
Gene Overview

MyGene.info: RAMP2
Alliance

gene page

Sequence Map

Chr11:101246028-101259546 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

13519 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 64.47 cM
Mapping Data

2 experiments

Human Ortholog

RAMP2, receptor activity modifying protein 2

Vertebrate Orthologs

8

Human Ortholog

RAMP2, receptor activity modifying protein 2
Orthology source: HomoloGene, HGNC
Links

HGNC:9844

NCBI Gene ID: 10266

neXtProt AC: NX_O60895

UniProt: O60895
Chr Location

17q21.2; chr17:42761194-42763041 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4274
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 macaque, rhesus
HCOP

human homology predictions: RAMP2
Gene Tree

Ramp2

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Phenotype Summary

24 phenotypes from 2 alleles in 3 genetic backgrounds
4 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

3
Targeted

6
Genomic Mutations

1 involving Ramp2
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available

Mice homozygous for a null allele exhibit embryonic lethality. Mice heterozygous for the null allele exhibit decreased litter size beyond the loss of homozygous embryos.

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All GO Annotations

47
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

31
Tissues

23
cDNA Data

10
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RAMP2

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Ramp2 interacts with 217 markers (Mir10a, Mir10b, Mir15a, ...) View All

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All Sequences

51
RefSeq

2
UniProt

6
CCDS

CCDS25457.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000002758	VEGA Gene Model \| MGI Sequence Detail	13519	C57BL/6J	± kb
transcript	OTTMUST00000005496	VEGA \| MGI Sequence Detail	1178	Not Applicable
polypeptide	OTTMUSP00000002615	VEGA \| MGI Sequence Detail	189	Not Applicable

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SNPs within 2kb

27 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000013706 receptor activity-modifying protein 2

(term hierarchy)
InterPro Domains

IPR038126 RAMP domain superfamily

IPR006985 Receptor activity modifying protein

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All nucleic 16

cDNA 14

Primer pair 1

Other 1

Microarray probesets 6

Summaries

All 52

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 18
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:246716 Xian X, et al., Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells. Endocrinology. 2017 May 01;158(5):1359-1372

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/17/2018 MGI 6.11