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Ramp2
Gene Detail
Symbol

Name
ID
Ramp2
receptor (calcitonin) activity modifying protein 2
MGI:1859650
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101246028-101259546 bp, + strand
From VEGA annotation of GRCm38

  13519 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: RAMP2
Gene Tree: Ramp2

Human
homologs
RAMP2, receptor (G protein-coupled) activity modifying protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10266
neXtProt AC: NX_O60895

Human Chr (Location): 17q12-q21.1; chr17:42761194-42763041 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Genomic Mutations involving Ramp2 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit embryonic lethality. Mice heterozygous for the null allele exhibit decreased litter size beyond the loss of homozygous embryos.
 
Phenotype Images(4)
Interactions
Ramp2 interacts with 217 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process adherens junction assembly, angiogenesis, ...
Component cell surface, cytoplasm, ...
Function coreceptor activity, protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (15)    Tissues (15)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
RT-PCR 3
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RAMP2    NEW 
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000002758 (Evidence)
Ensembl Gene Model ENSMUSG00000001240 (Evidence)
Entrez Gene 54409 (Evidence)
DFCI TC1574909, TC1699408
Consensus CDS Project CCDS25457.1
International Mouse Phenotyping Consortium Status Ramp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002758 VEGA Gene Model | MGI Sequence Detail 13519 C57BL/6J ±  kb
transcript OTTMUST00000005496 VEGA | MGI Sequence Detail 1178 Not Applicable 
polypeptide OTTMUSP00000002615 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006985 Receptor activity modifying protein
Protein Ontology PR:000013706 receptor activity-modifying protein 2
References
(Earliest) J:61899 Ono Y, et al., Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem Biophys Res Commun. 2000 Apr 29;271(1):197-202
(Latest) J:212965 Uetake R, et al., Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection. PLoS One. 2014;9(2):e87667
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory