Ramp2 MGI Mouse Gene Detail - MGI:1859650 - receptor (calcitonin) activity modifying protein 2

Symbol

Ramp2
Name

receptor (calcitonin) activity modifying protein 2

Feature Type

protein coding gene
IDs

MGI:1859650
NCBI Gene: 54409
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:101137160-101139076 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 64.47 cM
Mapping Data

2 experiments

SNPs within 2kb

155 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859650	protein coding gene	Chr11:101136854-101150372 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019188	protein coding gene	Chr11:104086845-104102691 (+)
A/J	MGP_AJ_G0019156	protein coding gene	Chr11:99712120-99726626 (+)
AKR/J	MGP_AKRJ_G0019125	protein coding gene	Chr11:102810314-102823733 (+)
BALB/cJ	MGP_BALBcJ_G0019130	protein coding gene	Chr11:100199482-100213011 (+)
C3H/HeJ	MGP_C3HHeJ_G0018939	protein coding gene	Chr11:102982766-102997776 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019579	protein coding gene	Chr11:107317115-107338132 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017205	protein coding gene	Chr11:97127199-97140086 (+)
CAST/EiJ	MGP_CASTEiJ_G0018493	protein coding gene	Chr11:103971281-103986605 (+)
CBA/J	MGP_CBAJ_G0018908	protein coding gene	Chr11:111765470-111780623 (+)
DBA/2J	MGP_DBA2J_G0019020	protein coding gene	Chr11:99239687-99253559 (+)
FVB/NJ	MGP_FVBNJ_G0019010	protein coding gene	Chr11:98786982-98800307 (+)
LP/J	MGP_LPJ_G0019089	protein coding gene	Chr11:104628526-104647649 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019041	protein coding gene	Chr11:111331017-111346305 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019617	protein coding gene	Chr11:103134132-103153344 (+)
PWK/PhJ	MGP_PWKPhJ_G0018256	protein coding gene	Chr11:100296112-100309726 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018048	protein coding gene	Chr11:102877179-102890584 (+)
WSB/EiJ	MGP_WSBEiJ_G0018542	protein coding gene	Chr11:103133169-103146380 (+)

Human Ortholog

RAMP2, receptor activity modifying protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAMP2, receptor activity modifying protein 2
Links

HGNC:9844

NCBI Gene ID: 10266

UniProt: O60895
Chr Location

17q21.2; chr17:42758447-42763041 (+) GRCh38

MGI Vertebrate Homology

Ramp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAMP2
Gene Tree

Ramp2

Diseases

1 with human RAMP2 associations

				Human Disease	Mouse Models
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

24 phenotypes from 2 alleles in 3 genetic backgrounds
4 images
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Gene trapped

1
Targeted

6
Genomic Mutations

1 involving Ramp2
Incidental Mutations

APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality. Mice heterozygous for the null allele exhibit decreased litter size beyond the loss of homozygous embryos.

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All GO Annotations

88
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

30
cDNA Data

12
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RAMP2

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All Sequences

54
RefSeq

2
UniProt

6
CCDS

CCDS25457.1

Ensembl

ENSMUSG00000001240 (Evidence)
NCBI Gene

54409

			Length	Strain/Species	Flank
genomic	54409	NCBI Gene Model \| MGI Sequence Detail	1917	C57BL/6J	± kb
transcript	NM_019444	RefSeq \| MGI Sequence Detail	872	ZRU/MplStud
polypeptide	Q9WUP0	UniProt \| EBI \| MGI Sequence Detail	189	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013706 receptor activity-modifying protein 2

(term hierarchy)
InterPro Domains

IPR038126 RAMP domain superfamily

IPR006985 Receptor activity modifying protein
GlyGen

Q9WUP0 4 sites

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All nucleic 20

cDNA 16

Primer pair 3

Other 1

Microarray probesets 6

Summaries

All 73

Developmental Gene Expression 15

Gene Ontology 11

Phenotypes 28
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:360305 Zhu Z, et al., Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors and is Required for Placenta Morphogenesis and Vasculature Formation. Adv Sci (Weinh). 2024 Aug;11(32):e2400238

TSS for Ramp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105054	Chr11:101136822-101136870 (+)	-314 bp
Tssr105055	Chr11:101136873-101136884 (+)	-281 bp
Tssr105056	Chr11:101136889-101136894 (+)	-268 bp
Tssr105057	Chr11:101137155-101137158 (+)	-3 bp
Tssr105058	Chr11:101137171-101137176 (+)	14 bp
Tssr105059	Chr11:101137182-101137196 (+)	29 bp
Tssr105060	Chr11:101137209-101137217 (+)	53 bp
Tssr105061	Chr11:101137231-101137248 (+)	80 bp
Tssr105062	Chr11:101137750-101137761 (+)	596 bp
Tssr3675	Chr11:101137763-101137783 (+)	613 bp
Tssr105063	Chr11:101137786-101137807 (+)	637 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24