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Otud5 Gene Detail
Summary
  • Symbol
    Otud5
  • Name
    OTU domain containing 5
  • Synonyms
    Duba, DXImx46e, Sfc7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859615
    NCBI Gene: 54644
  • Gene Overview
    MyGene.info: OTUD5
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7841364-7876626 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859615
protein coding gene ChrX:7841346-7876626 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035526
protein coding gene ChrX:2461329-2497492 (+)
A/J MGP_AJ_G0035504
protein coding gene ChrX:2422741-2459965 (+)
AKR/J MGP_AKRJ_G0035436
protein coding gene ChrX:2542220-2577380 (+)
BALB/cJ MGP_BALBcJ_G0035500
protein coding gene ChrX:2452965-2488603 (+)
C3H/HeJ MGP_C3HHeJ_G0035208
protein coding gene ChrX:2513522-2550062 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036024
protein coding gene ChrX:2552086-2587681 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032900
protein coding gene ChrX:1988101-2021377 (+)
CAST/EiJ MGP_CASTEiJ_G0034509
protein coding gene ChrX:2400164-2437736 (+)
CBA/J MGP_CBAJ_G0035178
protein coding gene ChrX:2668427-2705772 (+)
DBA/2J MGP_DBA2J_G0035335
protein coding gene ChrX:2449114-2484388 (+)
FVB/NJ MGP_FVBNJ_G0035282
protein coding gene ChrX:2408395-2443605 (+)
LP/J MGP_LPJ_G0035413
protein coding gene ChrX:2482566-2519399 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035322
protein coding gene ChrX:2640855-2677481 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036042
protein coding gene ChrX:2449896-2485873 (+)
PWK/PhJ MGP_PWKPhJ_G0034210
protein coding gene ChrX:2378188-2414497 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034048
protein coding gene ChrX:2427737-2468862 (+)
WSB/EiJ MGP_WSBEiJ_G0034632
protein coding gene ChrX:2456222-2495709 (+)



Homology
more
  • Human Ortholog
    OTUD5, OTU deubiquitinase 5
  • Vertebrate Orthologs
    4
  • Human Ortholog
    OTUD5, OTU deubiquitinase 5
    Orthology source: HGNC
  • Synonyms
    DUBA
  • Links
    NCBI Gene ID: 55593
    neXtProt AC: NX_Q96G74
    UniProt: Q96G74

  • Chr Location
    Xp11.23; chrX:48922024-48958386 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele exhibit abnormalities in developmental patterning and embryo turning. Mice homozygous for a conditional allele activated in T cells exhibit increased Th17 differentiation and susceptibility to injection with anti-CD3 antibodies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031154 Ensembl Gene Model | MGI Sequence Detail 35263 C57BL/6J ±  kb
transcript ENSMUST00000115667 Ensembl | MGI Sequence Detail 2708 Not Applicable  
polypeptide ENSMUSP00000111331 Ensembl | MGI Sequence Detail 571 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 20
    Genomic 3
    cDNA 17

    Microarray probesets 8
Other
Accession IDs
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MGI:2147820, MGI:2147900, MGI:2148034
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:62168 Means GD, et al., A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Genomics. 2000 May 1;65(3):213-23
  • Latest
    J:219495 Rutz S, et al., Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015 Feb 19;518(7539):417-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory