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Slc22a7 Gene Detail
Summary
  • Symbol
    Slc22a7
  • Name
    solute carrier family 22 (organic anion transporter), member 7
  • Synonyms
    NLT, OAT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859559
    NCBI Gene: 108114
  • Gene Overview
    MyGene.info: SLC22A7
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46432185-46438477 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859559
protein coding gene Chr17:46432185-46438477 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023815
protein coding gene Chr17:47483303-47489604 (-)
A/J MGP_AJ_G0023773
protein coding gene Chr17:46352358-46358714 (-)
AKR/J MGP_AKRJ_G0023744
protein coding gene Chr17:46693058-46701162 (-)
BALB/cJ MGP_BALBcJ_G0023777
protein coding gene Chr17:46249898-46257256 (-)
C3H/HeJ MGP_C3HHeJ_G0023541
protein coding gene Chr17:47434127-47440329 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024220
protein coding gene Chr17:49543034-49550467 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021670
protein coding gene Chr17:43142583-43149157 (-)
CAST/EiJ MGP_CASTEiJ_G0023022
protein coding gene Chr17:47512868-47519088 (-)
CBA/J MGP_CBAJ_G0023517
protein coding gene Chr17:51318535-51325480 (-)
DBA/2J MGP_DBA2J_G0023643
protein coding gene Chr17:45132320-45139527 (-)
FVB/NJ MGP_FVBNJ_G0023610
protein coding gene Chr17:44744755-44749729 (-)
LP/J MGP_LPJ_G0023724
protein coding gene Chr17:48172370-48180094 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023639
protein coding gene Chr17:50874890-50884704 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024265
protein coding gene Chr17:47046228-47053658 (-)
PWK/PhJ MGP_PWKPhJ_G0022767
protein coding gene Chr17:44467586-44474468 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022582
protein coding gene Chr17:43917218-43925610 (-)
WSB/EiJ MGP_WSBEiJ_G0023087
protein coding gene Chr17:47590973-47597157 (-)



Homology
more
  • Human Ortholog
    SLC22A7, solute carrier family 22 member 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC22A7, solute carrier family 22 member 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hOAT11, NLT, OAT2
  • Links
    NCBI Gene ID: 10864
    neXtProt AC: NX_Q9Y694
    UniProt: Q9Y694

  • Chr Location
    6p21.1; chr6:43295694-43305538 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 108114 NCBI Gene Model | MGI Sequence Detail 6293 C57BL/6J ±  kb
transcript NM_144856 RefSeq | MGI Sequence Detail 2007 C57BL/6  
polypeptide Q91WU2 UniProt | EBI | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR036259 MFS transporter superfamily
    IPR004749 Organic cation transport protein/SVOP
Molecular
Reagents
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  • All nucleic 53
    Genomic 1
    cDNA 50
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:61599 Pavlova A, et al., Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am J Physiol Renal Physiol. 2000 Apr;278(4):F635-43
  • Latest
    J:228779 Alpern D, et al., TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Elife. 2014;3:e03613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory