Nup210 MGI Mouse Gene Detail - MGI:1859555

Symbol

Nup210
Name

nucleoporin 210
Synonyms

gp190, gp210, Pom210

Feature Type

protein coding gene
IDs

MGI:1859555
NCBI Gene: 54563
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr6:91013068-91116829 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 40.30 cM
Mapping Data

3 experiments

SNPs within 2kb

928 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859555	protein coding gene	Chr6:91013067-91118322 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031042	protein coding gene	Chr6:92586558-92695364 (-)
A/J	MGP_AJ_G0031010	protein coding gene	Chr6:89060139-89165180 (-)
AKR/J	MGP_AKRJ_G0030942	protein coding gene	Chr6:91530453-91640081 (-)
BALB/cJ	MGP_BALBcJ_G0031022	protein coding gene	Chr6:89001291-89105651 (-)
C3H/HeJ	MGP_C3HHeJ_G0030686	protein coding gene	Chr6:92799280-92910108 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031481	protein coding gene	Chr6:95002589-95116167 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028649	protein coding gene	Chr6:87037098-87142838 (-)
CAST/EiJ	MGP_CASTEiJ_G0030129	protein coding gene	Chr6:91646184-91755101 (-)
CBA/J	MGP_CBAJ_G0030708	protein coding gene	Chr6:98531910-98646459 (-)
DBA/2J	MGP_DBA2J_G0030861	protein coding gene	Chr6:88246416-88350527 (-)
FVB/NJ	MGP_FVBNJ_G0030815	protein coding gene	Chr6:87453982-87556806 (-)
LP/J	MGP_LPJ_G0030941	protein coding gene	Chr6:92544480-92654619 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030849	protein coding gene	Chr6:102612294-102721146 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031508	protein coding gene	Chr6:91373803-91484710 (-)
PWK/PhJ	MGP_PWKPhJ_G0029845	protein coding gene	Chr6:87171299-87296446 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029674	protein coding gene	Chr6:90283150-90393641 (-)
WSB/EiJ	MGP_WSBEiJ_G0030213	protein coding gene	Chr6:91833278-91941832 (-)

Human Ortholog

NUP210, nucleoporin 210

Vertebrate Orthologs

10

Human Ortholog

NUP210, nucleoporin 210
Orthology source: HomoloGene, HGNC
Synonyms

GP210, POM210
Links

HGNC:30052

NCBI Gene ID: 23225

neXtProt AC: NX_Q8TEM1

UniProt: Q8TEM1
Chr Location

3p25.1; chr3:13316230-13420319 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41286
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NUP210
Gene Tree

Nup210

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Phenotype Summary

10 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (ENU)

1
Endonuclease-mediated

1
Gene trapped

25
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Nup210
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a null allele exhibit decreased naive T cells and increased activated T cells due to impaired peripheral T cell development.

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All GO Annotations

10
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

668
Tissues

33
cDNA Data

91
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup210

ZFIN nup210

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Nup210 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

56
RefSeq

4
UniProt

5
CCDS

CCDS39565.1
UniGene

28162

Ensembl

ENSMUSG00000030091 (Evidence)
NCBI Gene

54563

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030091	Ensembl Gene Model \| MGI Sequence Detail	103762	C57BL/6J	± kb
transcript	ENSMUST00000032179	Ensembl \| MGI Sequence Detail	7037	Not Applicable
polypeptide	ENSMUSP00000032179	Ensembl \| MGI Sequence Detail	1886	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011513 nuclear pore membrane glycoprotein 210

(term hierarchy)
InterPro Domains

IPR003343 Bacterial Ig-like, group 2

IPR008964 Invasin/intimin cell-adhesion fragments

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All nucleic 95

cDNA 93

Primer pair 1

Other 1

Microarray probesets 5

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MGI:2141476

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 10
Earliest

J:59628 Olsson M, et al., cDNA cloning and embryonic expression of mouse nuclear pore membrane glycoprotein 210 mRNA. Kidney Int. 1999 Sep;56(3):827-38
Latest

J:282451 Borlido J, et al., Nuclear pore complex-mediated modulation of TCR signaling is required for naive CD4(+) T cell homeostasis. Nat Immunol. 2018 Jun;19(6):594-605

TSS for Nup210:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62073	Chr6:91117008-91117023 (-)	-187 bp
Tssr62072	Chr6:91116836-91116858 (-)	-18 bp
Tssr62071	Chr6:91116785-91116832 (-)	20 bp
Tssr62070	Chr6:91116761-91116775 (-)	61 bp
Tssr62069	Chr6:91116471-91116480 (-)	353 bp
Tssr62067	Chr6:91030080-91030084 (-)	86,747 bp
Tssr62066	Chr6:91024081-91024086 (-)	92,745 bp
Tssr62065	Chr6:91024036-91024040 (-)	92,791 bp
Tssr62064	Chr6:91023996-91024002 (-)	92,830 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/20/2020 MGI 6.16