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Lrrc6 Gene Detail
Summary
  • Symbol
    Lrrc6
  • Name
    leucine rich repeat containing 6 (testis)
  • Synonyms
    LRTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859553
    NCBI Gene: 54562
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:66379858-66500910 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.22 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    585 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859553
protein coding gene Chr15:66379858-66500910 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021904
protein coding gene Chr15:65883704-66003815 (-)
A/J MGP_AJ_G0021863
protein coding gene Chr15:63383294-63507914 (-)
AKR/J MGP_AKRJ_G0021845
protein coding gene Chr15:65146540-65268945 (-)
BALB/cJ MGP_BALBcJ_G0021870
protein coding gene Chr15:63569148-63689538 (-)
C3H/HeJ MGP_C3HHeJ_G0021643
protein coding gene Chr15:65258711-65384980 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022309
protein coding gene Chr15:68443332-68577838 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019846
protein coding gene Chr15:60173666-60288486 (-)
CAST/EiJ MGP_CASTEiJ_G0021162
protein coding gene Chr15:65917994-66042261 (-)
CBA/J MGP_CBAJ_G0021609
protein coding gene Chr15:70718125-70845521 (-)
DBA/2J MGP_DBA2J_G0021734
protein coding gene Chr15:63174403-63295519 (-)
FVB/NJ MGP_FVBNJ_G0021716
protein coding gene Chr15:62208054-62332609 (-)
LP/J MGP_LPJ_G0021806
protein coding gene Chr15:65778433-65899691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021739
protein coding gene Chr15:75804688-75943753 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022331
protein coding gene Chr15:65519759-65645466 (-)
PWK/PhJ MGP_PWKPhJ_G0020903
protein coding gene Chr15:63257628-63385181 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020744
protein coding gene Chr15:65375939-65503357 (-)
WSB/EiJ MGP_WSBEiJ_G0021214
protein coding gene Chr15:65487497-65612273 (-)



Homology
more
  • Human Ortholog
    LRRC6, leucine rich repeat containing 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRC6, leucine rich repeat containing 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD19, LRTP, TSLRP
  • Links
    NCBI Gene ID: 23639
    neXtProt AC: NX_Q86X45
    UniProt: Q86X45

  • Chr Location
    8q24.22; chr8:132570419-132685039 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 34534
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRRC6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LRRC6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54562 NCBI Gene Model | MGI Sequence Detail 121053 C57BL/6J ±  kb
transcript NM_019457 RefSeq | MGI Sequence Detail 2084 C57BL/6  
polypeptide O88978 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 4
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:258369 Inaba Y, et al., Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6. Genes Cells. 2016 Jul;21(7):728-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory