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Lrrc6 Gene Detail
Summary
  • Symbol
    Lrrc6
  • Name
    leucine rich repeat containing 6 (testis)
  • Synonyms
    LRTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859553
    NCBI Gene: 54562
Location & Maps
more
  • Sequence Map
    Chr15:66379858-66500910 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      121053 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    LRRC6, leucine rich repeat containing 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRC6, leucine rich repeat containing 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CILD19, LRTP, TSLRP
  • Links
    NCBI Gene ID: 23639
    neXtProt AC: NX_Q86X45

  • Chr Location
    8q24.22; chr8:132570416-132685097 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 34534
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LRRC6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LRRC6 associations

Human Disease Mouse Models
       Ciliary Dyskinesia, Primary, 19; CILD19   OMIM: 614935
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    5 involving Lrrc6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037898 VEGA Gene Model | MGI Sequence Detail 121053 C57BL/6J ±  kb
transcript OTTMUST00000097713 VEGA | MGI Sequence Detail 2084 Not Applicable  
polypeptide OTTMUSP00000054804 VEGA | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    585 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009939 leucine-rich repeat-containing protein 6
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003603 U2A'/phosphoprotein 32 family A, C-terminal
Molecular
Reagents
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  • All nucleic 9
    cDNA 9

    Microarray probesets 4
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:61958 Xue JC, et al., Identification of a novel testis-specific leucine-rich protein in humans and mice. Biol Reprod. 2000 May;62(5):1278-84
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory