About   Help   FAQ
Btnl2 Gene Detail
Summary
  • Symbol
    Btnl2
  • Name
    butyrophilin-like 2
  • Synonyms
    BTL-II, BTLN2, butyrophylin-like MHC class II associated, NG9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859549
    NCBI Gene: 547431
  • Gene Overview
    MyGene.info: BTNL2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34354822-34369493 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859549
protein coding gene Chr17:34354789-34369493 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023571
protein coding gene Chr17:34364093-34378513 (+)
A/J MGP_AJ_G0023533
protein coding gene Chr17:33197661-33212107 (+)
AKR/J MGP_AKRJ_G0023498
protein coding gene Chr17:33587824-33603890 (+)
BALB/cJ MGP_BALBcJ_G0023537
protein coding gene Chr17:33357273-33372024 (+)
C3H/HeJ MGP_C3HHeJ_G0023297
protein coding gene Chr17:33945791-33961195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023977
protein coding gene Chr17:35648591-35669391 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021456
protein coding gene Chr17:31166449-31179672 (+)
CAST/EiJ MGP_CASTEiJ_G0022797
protein coding gene Chr17:34030057-34046402 (+)
CBA/J MGP_CBAJ_G0023275
protein coding gene Chr17:37118462-37136896 (+)
DBA/2J MGP_DBA2J_G0023404
protein coding gene Chr17:32541568-32556481 (+)
FVB/NJ MGP_FVBNJ_G0023370
protein coding gene Chr17:32400505-32414980 (+)
LP/J MGP_LPJ_G0023481
protein coding gene Chr17:34630910-34648160 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023393
protein coding gene Chr17:36088087-36104521 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024020
protein coding gene Chr17:33917282-33933397 (+)
PWK/PhJ MGP_PWKPhJ_G0022547
protein coding gene Chr17:31480283-31495103 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022362
protein coding gene Chr17:31879889-31895533 (+)
WSB/EiJ MGP_WSBEiJ_G0022858
protein coding gene Chr17:33958898-33975783 (+)



Homology
more
  • Human Ortholog
    BTNL2, butyrophilin like 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    BTNL2, butyrophilin like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTL-II, BTN7, HSBLMHC1, SS2
  • Links
    NCBI Gene ID: 56244
    neXtProt AC: NX_Q9UIR0
    UniProt: Q9UIR0

  • Chr Location
    6p21.32; chr6:32393339-32408879 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human BTNL2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024340 Ensembl Gene Model | MGI Sequence Detail 14672 C57BL/6J ±  kb
transcript ENSMUST00000025198 Ensembl | MGI Sequence Detail 2564 Not Applicable  
polypeptide ENSMUSP00000025198 Ensembl | MGI Sequence Detail 514 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 8
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685161
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:61935 Stammers M, et al., BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Immunogenetics. 2000 Apr;51(4-5):373-82
  • Latest
    J:193462 Swanson RM, et al., Butyrophilin-like 2 Modulates B7 Costimulation To Induce Foxp3 Expression and Regulatory T Cell Development in Mature T Cells. J Immunol. 2013 Mar 1;190(5):2027-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory