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Btnl2 Gene Detail
Summary
  • Symbol
    Btnl2
  • Name
    butyrophilin-like 2
  • Synonyms
    BTL-II, BTLN2, butyrophylin-like MHC class II associated, NG9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859549
    NCBI Gene: 547431
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34573796-34588469 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859549
 protein coding gene Chr17:34573763-34588469 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023571
 protein coding gene Chr17:34364093-34378513 (+)
A/J MGP_AJ_G0023533
 protein coding gene Chr17:33197661-33212107 (+)
AKR/J MGP_AKRJ_G0023498
 protein coding gene Chr17:33587824-33603890 (+)
BALB/cJ MGP_BALBcJ_G0023537
 protein coding gene Chr17:33357273-33372024 (+)
C3H/HeJ MGP_C3HHeJ_G0023297
 protein coding gene Chr17:33945791-33961195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023977
 protein coding gene Chr17:35648591-35669391 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021456
 protein coding gene Chr17:31166449-31179672 (+)
CAST/EiJ MGP_CASTEiJ_G0022797
 protein coding gene Chr17:34030057-34046402 (+)
CBA/J MGP_CBAJ_G0023275
 protein coding gene Chr17:37118462-37136896 (+)
DBA/2J MGP_DBA2J_G0023404
 protein coding gene Chr17:32541568-32556481 (+)
FVB/NJ MGP_FVBNJ_G0023370
 protein coding gene Chr17:32400505-32414980 (+)
LP/J MGP_LPJ_G0023481
 protein coding gene Chr17:34630910-34648160 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023393
 protein coding gene Chr17:36088087-36104521 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024020
 protein coding gene Chr17:33917282-33933397 (+)
PWK/PhJ MGP_PWKPhJ_G0022547
 protein coding gene Chr17:31480283-31495103 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022362
 protein coding gene Chr17:31879889-31895533 (+)
WSB/EiJ MGP_WSBEiJ_G0022858
 protein coding gene Chr17:33958898-33975783 (+)



Homology
more
  • Human Ortholog
    BTNL2, butyrophilin like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTNL2, butyrophilin like 2
  • Synonyms
    BTL-II, BTN7, HSBLMHC1, SS2
  • Links
    NCBI Gene ID: 56244
    neXtProt AC: NX_Q9UIR0
    UniProt: Q9UIR0

  • Chr Location
    6p21.32; chr6:32393339-32407181 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human BTNL2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show large bowel inflammation, loss of colonic crypt architecture, increase in pro-inflammatory cytokines in colonic tissue and a decrease in gamma-delta T17 cells in the intestinal epithelial lymphocyte population.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    48
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024340 Ensembl Gene Model | MGI Sequence Detail 14674 C57BL/6J ±  kb
    transcript ENSMUST00000025198 Ensembl | MGI Sequence Detail 2566 Not Applicable  
    polypeptide ENSMUSP00000025198 Ensembl | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685161
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 7
    • Earliest
      J:61935 Stammers M, et al., BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Immunogenetics. 2000 Apr;51(4-5):373-82
    • Latest
      J:321348 Du Y, et al., Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing gammadelta T cells. Nat Commun. 2022 Jan 11;13(1):231
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory