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Btnl2 Gene Detail
Summary
  • Symbol
    Btnl2
  • Name
    butyrophilin-like 2
  • Synonyms
    BTL-II, BTLN2, butyrophylin-like MHC class II associated, NG9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859549
    NCBI Gene: 547431
  • Gene Overview
    MyGene.info: BTNL2
Location & Maps
more
  • Sequence Map
    Chr17:34354822-34369493 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14672 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BTNL2, butyrophilin like 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    BTNL2, butyrophilin like 2
    Orthology source: HomoloGene
  • Synonyms
    BTL-II, BTN7, HSBLMHC1, SS2
  • Links
    NCBI Gene ID: 56244
    neXtProt AC: NX_Q9UIR0

  • Chr Location
    6p21.3; chr6:32393339-32408879 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human BTNL2 associations

Human Disease Mouse Models
       Sarcoidosis, Susceptibility to, 2; SS2   OMIM: 612387
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020172 VEGA Gene Model | MGI Sequence Detail 14672 C57BL/6J ±  kb
transcript OTTMUST00000047932 VEGA | MGI Sequence Detail 2564 Not Applicable  
polypeptide OTTMUSP00000021847 VEGA | MGI Sequence Detail 514 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685161
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:61935 Stammers M, et al., BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Immunogenetics. 2000 Apr;51(4-5):373-82
  • Latest
    J:193462 Swanson RM, et al., Butyrophilin-like 2 Modulates B7 Costimulation To Induce Foxp3 Expression and Regulatory T Cell Development in Mature T Cells. J Immunol. 2013 Mar 1;190(5):2027-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory