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Btnl2
Gene Detail
 Symbol
Name
ID
Btnl2
butyrophilin-like 2
MGI:1859549
Synonyms BTL-II, BTLN2, butyrophylin-like MHC class II associated, NG9
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:34354822-34369493 bp, + strand
From VEGA annotation of GRCm38

  14672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 cattle; 1 dog

Gene Tree: Btnl2

Human
homologs
Human Homolog BTNL2, butyrophilin-like 2 (MHC class II associated)
NCBI Gene ID 56244
neXtProt AC  NX_Q9UIR0
Human Synonyms  BTL-II, BTN7, HSBLMHC1, SS2
Human Chr (Location)  6p21.3; chr6:32394736-32407123 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human BTNL2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Btnl2 interacts with 147 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process negative regulation of T cell receptor signaling pathway, positive regulation of interleukin-2 secretion, ...
Component integral component of membrane, membrane
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (48)   
Theiler Stages: 16, 17, 18, 28
Assay TypeResults
RT-PCR 54
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(6) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020172 (Evidence)
Ensembl Gene ModelENSMUSG00000024340 (Evidence)
Entrez Gene547431 (Evidence)
UniGene441007
DFCITC1589769
DoTSDT.522453
Consensus CDS ProjectCCDS37585.1
International Mouse Knockout Project StatusBtnl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020172 VEGA Gene Model | MGI Sequence Detail 14672 C57BL/6J ±  kb
transcript OTTMUST00000047932 VEGA | MGI Sequence Detail 2564 Not Applicable 
polypeptide OTTMUSP00000021847 VEGA | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(15) UniProt(3)
Polymorphisms SNPs within 2kb(281 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
Protein Ontology PR:000004849 butyrophilin-like protein 2
References (Earliest) J:61935 Stammers M, et al., BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Immunogenetics. 2000 Apr;51(4-5):373-82
(Latest) J:193462 Swanson RM, et al., Butyrophilin-like 2 Modulates B7 Costimulation To Induce Foxp3 Expression and Regulatory T Cell Development in Mature T Cells. J Immunol. 2013 Mar 1;190(5):2027-35
All references(28)
Other
accession IDs
MGI:2685161

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory