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Hpgds Gene Detail
Summary
  • Symbol
    Hpgds
  • Name
    hematopoietic prostaglandin D synthase
  • Synonyms
    H-PGDS, Ptgds2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859384
    NCBI Gene: 54486
  • Gene Overview
    MyGene.info: HPGDS
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:65117293-65144908 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 30.11 cM, cytoband D-E
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859384
protein coding gene Chr6:65117293-65145015 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030830
protein coding gene Chr6:65043221-65070730 (-)
A/J MGP_AJ_G0030797
protein coding gene Chr6:62196132-62223709 (-)
AKR/J MGP_AKRJ_G0030725
protein coding gene Chr6:64178379-64205885 (-)
BALB/cJ MGP_BALBcJ_G0030808
protein coding gene Chr6:62602914-62630959 (-)
C3H/HeJ MGP_C3HHeJ_G0030904
protein coding gene Chr6:120027063-120054744 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031266
protein coding gene Chr6:66532342-66562917 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028459
protein coding gene Chr6:59540822-59567104 (-)
CAST/EiJ MGP_CASTEiJ_G0029920
protein coding gene Chr6:64440811-64471775 (-)
CBA/J MGP_CBAJ_G0030495
protein coding gene Chr6:69257784-69284676 (-)
DBA/2J MGP_DBA2J_G0030647
protein coding gene Chr6:61893107-61920637 (-)
FVB/NJ MGP_FVBNJ_G0030600
protein coding gene Chr6:61426887-61454669 (-)
LP/J MGP_LPJ_G0030731
protein coding gene Chr6:64994162-65021678 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030635
protein coding gene Chr6:73020842-73049313 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031292
protein coding gene Chr6:64131320-64158765 (-)
PWK/PhJ MGP_PWKPhJ_G0029635
protein coding gene Chr6:61062214-61090197 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029463
protein coding gene Chr6:63659454-63689603 (-)
WSB/EiJ MGP_WSBEiJ_G0030002
protein coding gene Chr6:64420976-64448665 (-)



Homology
more
  • Human Ortholog
    HPGDS, hematopoietic prostaglandin D synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HPGDS, hematopoietic prostaglandin D synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GSTS, GSTS1, GSTS1-1, PGD2, PGDS
  • Links
    NCBI Gene ID: 27306
    neXtProt AC: NX_O60760
    UniProt: O60760

  • Chr Location
    4q22.3; chr4:94298556-94342876 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display increased IL-2 synthesis and heightened proliferation of ex vivo lymph node cultures in response to BSA or concanavalin A challenge, and fail to resolve a Th1-driven delayed type hypersensitivity reaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029919 Ensembl Gene Model | MGI Sequence Detail 27616 C57BL/6J ±  kb
    transcript ENSMUST00000031982 Ensembl | MGI Sequence Detail 3476 Not Applicable  
    polypeptide ENSMUSP00000031982 Ensembl | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 13
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 26
    • Earliest
      J:62511 Kanaoka Y, et al., Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. Eur J Biochem. 2000 Jun;267(11):3315-22
    • Latest
      J:224362 Nakamura T, et al., PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nat Commun. 2015;6:7514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory