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Mkrn1 Gene Detail
Summary
  • Symbol
    Mkrn1
  • Name
    makorin, ring finger protein, 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859353
    NCBI Gene: 54484
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:39397804-39420462 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 18.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859353
protein coding gene Chr6:39397804-39423299 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030597
protein coding gene Chr6:37774138-37802954 (-)
A/J MGP_AJ_G0030570
protein coding gene Chr6:36125916-36148803 (-)
AKR/J MGP_AKRJ_G0030497
protein coding gene Chr6:37279366-37304450 (-)
BALB/cJ MGP_BALBcJ_G0030580
protein coding gene Chr6:36345370-36370226 (-)
C3H/HeJ MGP_C3HHeJ_G0030293
protein coding gene Chr6:37293766-37320651 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031034
protein coding gene Chr6:38702394-38733798 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028246
protein coding gene Chr6:34023446-34046235 (-)
CAST/EiJ MGP_CASTEiJ_G0029695
protein coding gene Chr6:37197094-37222803 (-)
CBA/J MGP_CBAJ_G0030271
protein coding gene Chr6:40228995-40270040 (-)
DBA/2J MGP_DBA2J_G0030415
protein coding gene Chr6:35949905-35972033 (-)
FVB/NJ MGP_FVBNJ_G0030369
protein coding gene Chr6:35735940-35759937 (-)
LP/J MGP_LPJ_G0030502
protein coding gene Chr6:37805229-37832210 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030405
protein coding gene Chr6:42564338-42596583 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031064
protein coding gene Chr6:37227452-37253112 (-)
PWK/PhJ MGP_PWKPhJ_G0029409
protein coding gene Chr6:35631110-35654393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029245
protein coding gene Chr6:36953210-36977805 (-)
WSB/EiJ MGP_WSBEiJ_G0029771
protein coding gene Chr6:37172685-37201930 (-)



Homology
more
  • Human Ortholog
    MKRN1, makorin ring finger protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MKRN1, makorin ring finger protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RNF61
  • Links
    NCBI Gene ID: 23608
    neXtProt AC: NX_Q9UHC7
    UniProt: Q9UHC7

  • Chr Location
    7q34; chr7:140453040-140479569 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Mice homozygous for a gene-trapped allele are viable and fertile, and show normal kidney morphology, eyelid development, and skeletal morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029922 Ensembl Gene Model | MGI Sequence Detail 22659 C57BL/6J ±  kb
transcript ENSMUST00000031985 Ensembl | MGI Sequence Detail 3046 Not Applicable  
polypeptide ENSMUSP00000031985 Ensembl | MGI Sequence Detail 481 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 11
References
more
  • Summaries
    All 40
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:62532 Gray TA, et al., The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Genomics. 2000 May 15;66(1):76-86
  • Latest
    J:229145 Kim JH, et al., Suppression of PPARgamma through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation. Cell Death Differ. 2014 Apr;21(4):594-603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory