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Mkrn1 Gene Detail
Summary
  • Symbol
    Mkrn1
  • Name
    makorin, ring finger protein, 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859353
    NCBI Gene: 54484
Location & Maps
more
  • Sequence Map
    Chr6:39397804-39420462 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22659 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 18.18 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MKRN1, makorin ring finger protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MKRN1, makorin ring finger protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RNF61
  • Links
    NCBI Gene ID: 23608
    neXtProt AC: NX_Q9UHC7

  • Chr Location
    7q34; chr7:140453040-140479569 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Mice homozygous for a gene-trapped allele are viable and fertile, and show normal kidney morphology, eyelid development, and skeletal morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024514 VEGA Gene Model | MGI Sequence Detail 22659 C57BL/6J ±  kb
transcript OTTMUST00000060154 VEGA | MGI Sequence Detail 3046 Not Applicable  
polypeptide OTTMUSP00000029332 VEGA | MGI Sequence Detail 481 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    36 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 11
References
more
  • Summaries
    All 38
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:62532 Gray TA, et al., The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Genomics. 2000 May 15;66(1):76-86
  • Latest
    J:229145 Kim JH, et al., Suppression of PPARgamma through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation. Cell Death Differ. 2014 Apr;21(4):594-603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory