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Nfat5 Gene Detail
Summary
  • Symbol
    Nfat5
  • Name
    nuclear factor of activated T cells 5
  • Synonyms
    B130038B15Rik, mKIAA0827, nfatz, OREBP, TonEBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859333
    NCBI Gene: 54446
  • Gene Overview
    MyGene.info: NFAT5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:107293470-107379517 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.93 cM, cytoband D2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859333
protein coding gene Chr8:107293001-107379517 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034099
protein coding gene Chr8:109738436-109835699 (+)
A/J MGP_AJ_G0034079
protein coding gene Chr8:105325609-105412322 (+)
AKR/J MGP_AKRJ_G0034005
protein coding gene Chr8:108400050-108488955 (+)
BALB/cJ MGP_BALBcJ_G0034072
protein coding gene Chr8:105533395-105620925 (+)
C3H/HeJ MGP_C3HHeJ_G0033784
protein coding gene Chr8:109124724-109217597 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034592
protein coding gene Chr8:113713498-113819721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031534
protein coding gene Chr8:98421677-98507762 (+)
CAST/EiJ MGP_CASTEiJ_G0033111
protein coding gene Chr8:108662807-108758057 (+)
CBA/J MGP_CBAJ_G0033757
protein coding gene Chr8:117431716-117519673 (+)
DBA/2J MGP_DBA2J_G0033912
protein coding gene Chr8:104653203-104740600 (+)
FVB/NJ MGP_FVBNJ_G0033857
protein coding gene Chr8:103596725-103685217 (+)
LP/J MGP_LPJ_G0034003
protein coding gene Chr8:109927612-110020572 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033902
protein coding gene Chr8:120549675-120662787 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034610
protein coding gene Chr8:108339963-108429878 (+)
PWK/PhJ MGP_PWKPhJ_G0032813
protein coding gene Chr8:104074352-104162441 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032652
protein coding gene Chr8:107045001-107137137 (+)
WSB/EiJ MGP_WSBEiJ_G0033226
protein coding gene Chr8:109051081-109145083 (+)



Homology
more
  • Human Ortholog
    NFAT5, nuclear factor of activated T cells 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFAT5, nuclear factor of activated T cells 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NF-AT5, NFATL1, NFATZ, OREBP, TONEBP
  • Links
    NCBI Gene ID: 10725
    neXtProt AC: NX_O94916
    UniProt: O94916

  • Chr Location
    16q22.1; chr16:69565952-69704666 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4811
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NFAT5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 6 alleles in 6 genetic backgrounds
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one of several knock-out allele exhibit lethality between E14.5 and E17.5 as well as around P10 with kidney, cardiac or immune defects depending on the allele.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003847 Ensembl Gene Model | MGI Sequence Detail 86048 C57BL/6J ±  kb
    transcript ENSMUST00000151114 Ensembl | MGI Sequence Detail 4982 Not Applicable  
    polypeptide ENSMUSP00000119370 Ensembl | MGI Sequence Detail 1552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 3
      cDNA 17
      Primer pair 3
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2142481, MGI:2442693
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 24
    • Earliest
      J:62063 Lopez-Rodriguez C, et al., NF-AT5: the NF-AT family of transcription factors expands in a new direction. Cold Spring Harb Symp Quant Biol. 1999;64:517-26
    • Latest
      J:254437 Serr I, et al., A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Sci Transl Med. 2018 Jan 3;10(422)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory