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Nfat5
Gene Detail
Symbol

Name
ID
Nfat5
nuclear factor of activated T cells 5
MGI:1859333
Synonyms
B130038B15Rik, mKIAA0827, nfatz, OREBP, TonEBP
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.93 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:107293470-107379517 bp, + strand
From VEGA annotation of GRCm38

  86048 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4811  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nfat5

Human
homologs
Human Homolog NFAT5, nuclear factor of activated T-cells 5, tonicity-responsive
NCBI Gene ID 10725
neXtProt AC  NX_O94916
Human Synonyms  NF-AT5, NFATL1, NFATZ, OREBP, TONEBP
Human Chr (Location)  16q22.1; chr16:69565966-69704666 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(9) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results partial or complete prenatal lethality. One null mutation results in renal atrophy while another results in impaired cardiac development.
 
Phenotype Images(1)
Interactions
Nfat5 interacts with 649 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (177)    Tissues (167)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 143
RT-PCR 13
RNase protection 7
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000033607 (Evidence)
Ensembl Gene ModelENSMUSG00000003847 (Evidence)
Entrez Gene54446 (Evidence)
DFCITC1590181, TC1594797, TC1575421, TC1605597, TC1618944, TC1629969, TC1622958
NIA Mouse Gene IndexU042927, U370193
Consensus CDS ProjectCCDS22648.2, CCDS40464.1, CCDS72168.1
International Mouse Knockout Project StatusNfat5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033607 VEGA Gene Model | MGI Sequence Detail 86048 C57BL/6J ±  kb
transcript OTTMUST00000084668 VEGA | MGI Sequence Detail 4982 Not Applicable 
polypeptide OTTMUSP00000045658 VEGA | MGI Sequence Detail 1552 Not Applicable 

For the selected sequences
All sequences(126) RefSeq(20) UniProt(23)
Polymorphisms
RFLP(1) : SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015646 Nuclear factor of activated T-cells 5
InterPro IPR008366 Nuclear factor of activated T cells (NFAT)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000011163 nuclear factor of activated T-cells 5
References
(Earliest) J:62063 Lopez-Rodriguez C, et al., NF-AT5: the NF-AT family of transcription factors expands in a new direction. Cold Spring Harb Symp Quant Biol. 1999;64:517-26
(Latest) J:201429 Wiig H, et al., Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest. 2013 Jul 1;123(7):2803-15
All references(69)
Other
accession IDs
MGI:2142481, MGI:2442693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory