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Cpsf3 Gene Detail
Summary
  • Symbol
    Cpsf3
  • Name
    cleavage and polyadenylation specificity factor 3
  • Synonyms
    73 kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859328
    NCBI Gene: 54451
  • Gene Overview
    MyGene.info: CPSF3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:21286297-21315056 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    430 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859328
protein coding gene Chr12:21285391-21315056 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019623
protein coding gene Chr12:18839520-18869109 (+)
A/J MGP_AJ_G0019590
protein coding gene Chr12:18130278-18159398 (+)
AKR/J MGP_AKRJ_G0019561
protein coding gene Chr12:18964593-18996846 (+)
BALB/cJ MGP_BALBcJ_G0019567
protein coding gene Chr12:18504337-18535708 (+)
C3H/HeJ MGP_C3HHeJ_G0019371
protein coding gene Chr12:18861377-18890288 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020015
protein coding gene Chr12:19539515-19569640 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017640
protein coding gene Chr12:17730717-17759971 (+)
CAST/EiJ MGP_CASTEiJ_G0018926
protein coding gene Chr12:16130500-16160542 (+)
CBA/J MGP_CBAJ_G0019343
protein coding gene Chr12:20272290-20306554 (+)
DBA/2J MGP_DBA2J_G0019456
protein coding gene Chr12:18162639-18192136 (+)
FVB/NJ MGP_FVBNJ_G0019447
protein coding gene Chr12:18063871-18092462 (+)
LP/J MGP_LPJ_G0019526
protein coding gene Chr12:18939193-18969912 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019482
protein coding gene Chr12:20095951-20125426 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020054
protein coding gene Chr12:18542036-18571655 (+)
PWK/PhJ MGP_PWKPhJ_G0018692
protein coding gene Chr12:15432012-15466843 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018481
protein coding gene Chr12:15830405-15861353 (+)
WSB/EiJ MGP_WSBEiJ_G0018977
protein coding gene Chr12:18724786-18757062 (+)



Homology
more
  • Human Ortholog
    CPSF3, cleavage and polyadenylation specific factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPSF3, cleavage and polyadenylation specific factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPSF73, CPSF-73
  • Links
    NCBI Gene ID: 51692
    neXtProt AC: NX_Q9UKF6
    UniProt: Q9UKF6

  • Chr Location
    2p25.1; chr2:9423537-9473110 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6499
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CPSF3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54451 NCBI Gene Model | MGI Sequence Detail 28760 C57BL/6J ±  kb
transcript NM_001364372 RefSeq | MGI Sequence Detail 2674 C57BL/6  
polypeptide Q9QXK7 UniProt | EBI | MGI Sequence Detail 684 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    14 Sequences
  • Protein Ontology
    PR:000005830 cleavage and polyadenylation specificity factor subunit 3
  • EC
  • InterPro Domains
    IPR022712 Beta-Casp domain
    IPR001279 Metallo-beta-lactamase
    IPR021718 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
    IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
    IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain
Molecular
Reagents
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  • All nucleic 119
    cDNA 119

    Microarray probesets 4
References
more
  • Summaries
    All 35
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory