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Cpsf3
Gene Detail
Symbol

Name
ID
Cpsf3
cleavage and polyadenylation specificity factor 3
MGI:1859328
Synonyms
73 kDa
Feature Type
protein coding gene
Genetic Map
Chromosome 12
8.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:21286297-21315056 bp, + strand
From NCBI annotation of GRCm38

  28760 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cpsf3

Human
homologs
Human Homolog CPSF3, cleavage and polyadenylation specific factor 3, 73kDa
NCBI Gene ID 51692
neXtProt AC  NX_Q9UKF6
Human Synonyms  CPSF73, CPSF-73
Human Chr (Location)  2p25.1; chr2:9423537-9473110 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cpsf3 interacts with 70 markers (Mir17, Mir20b, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(118)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(118) cDNA(118)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000054309 (Evidence)
Entrez Gene54451 (Evidence)
UniGene356778
DFCITC1593472, TC1572874, TC1705510, TC1715568
DoTSDT.97357780, DT.97340009, DT.101262277, DT.97334093, DT.493130
NIA Mouse Gene IndexU118555
EC3.1.27.-
Consensus CDS ProjectCCDS25834.1
International Mouse Knockout Project StatusCpsf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 54451 NCBI Gene Model | MGI Sequence Detail 28760 C57BL/6J ±  kb
transcript NM_018813 RefSeq | MGI Sequence Detail 2560 C57BL/6 
polypeptide Q9QXK7 UniProt | EBI | MGI Sequence Detail 684 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(7) UniProt(15)
Polymorphisms
SNPs within 2kb(434 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022712 Beta-Casp domain
InterPro IPR001279 Beta-lactamase-like
InterPro IPR021718 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
InterPro IPR011108 RNA-metabolising metallo-beta-lactamase
Protein Ontology PR:000005830 cleavage and polyadenylation specificity factor subunit 3
Graphical View of Protein Domain Structure
References
(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory