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Cpsf3 Gene Detail
Summary
  • Symbol
    Cpsf3
  • Name
    cleavage and polyadenylation specificity factor 3
  • Synonyms
    73 kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859328
    NCBI Gene: 54451
  • Gene Overview
    MyGene.info: CPSF3
Location & Maps
more
  • Sequence Map
    Chr12:21286297-21315056 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28760 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.30 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CPSF3, cleavage and polyadenylation specific factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPSF3, cleavage and polyadenylation specific factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPSF73, CPSF-73
  • Links
    NCBI Gene ID: 51692
    neXtProt AC: NX_Q9UKF6

  • Chr Location
    2p25.1; chr2:9423537-9473110 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6499
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CPSF3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54451 NCBI Gene Model | MGI Sequence Detail 28760 C57BL/6J ±  kb
transcript NM_018813 RefSeq | MGI Sequence Detail 2560 C57BL/6  
polypeptide Q9QXK7 UniProt | EBI | MGI Sequence Detail 684 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    430 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000005830 cleavage and polyadenylation specificity factor subunit 3
  • EC
  • InterPro Domains
    IPR022712 Beta-Casp domain
    IPR001279 Metallo-beta-lactamase
    IPR021718 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
    IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain
Molecular
Reagents
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  • All nucleic 118
    cDNA 118

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory