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Il1f5
Gene Detail
Symbol

Name
ID
Il1f5
interleukin 1 family, member 5 (delta)
MGI:1859325
Synonyms
FIL1delta, IL1F5, IL-1H3, IL1HY1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
16.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:24276954-24283426 bp, + strand
From VEGA annotation of GRCm38

  6473 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10453  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Il1f5

Human
homologs
Human Homolog IL36RN, interleukin 36 receptor antagonist
NCBI Gene ID 26525
neXtProt AC  NX_Q9UBH0
Human Synonyms  FIL1, FIL1D, FIL1(DELTA), IL1F5, IL1HY1, IL1L1, IL1RP3, IL-36Ra, IL36RA, PSORP
Human Chr (Location)  2q14; chr2:113058638-113064744 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IL36RN
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for a reporter allele are overtly normal with no apparent histopathological abnormalities or immune cell alterations. Mice homozygous for a knock-out allele exhibit increased sensitivity to IMQ-induced psoriasis.
 
Phenotype Images(1)
Interactions
Il1f5 interacts with 235 markers (Mir17, Mir18b, Mir20a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011958 (Evidence)
Ensembl Gene ModelENSMUSG00000026983 (Evidence)
Entrez Gene54450 (Evidence)
UniGene29261
DFCITC1694699, TC1633500, TC1585944
DoTSDT.101367367, DT.91337495, DT.522869
NIA Mouse Gene IndexU001465
PDB1MD6
Consensus CDS ProjectCCDS50519.1
International Mouse Knockout Project StatusIl1f5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011958 VEGA Gene Model | MGI Sequence Detail 6473 C57BL/6J ±  kb
transcript OTTMUST00000028270 VEGA | MGI Sequence Detail 1403 Not Applicable 
polypeptide OTTMUSP00000012795 VEGA | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
InterPro IPR027171 Interleukin-36 receptor antagonist
Protein Ontology PR:000008988 interleukin-1 family member 5
References
(Earliest) J:57981 Mulero JJ, et al., IL1HY1: A novel interleukin-1 receptor antagonist gene. Biochem Biophys Res Commun. 1999 Oct 5;263(3):702-6
(Latest) J:193548 Tortola L, et al., Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest. 2012 Nov 1;122(11):3965-76
All references(43)
Other
accession IDs
MGI:2138922

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory