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Il1f5
Gene Detail
Symbol

Name
ID
Il1f5
interleukin 1 family, member 5 (delta)
MGI:1859325
Synonyms
FIL1delta, IL1F5, IL-1H3, IL1HY1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
16.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:24276954-24283426 bp, + strand
From VEGA annotation of GRCm38

  6473 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10453  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL36RN
Gene Tree: Il1f5

Human
homologs
IL36RN, interleukin 36 receptor antagonist
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26525
neXtProt AC: NX_Q9UBH0

Human Synonyms: FIL1, FIL1D, FIL1(DELTA), IL1F5, IL1HY1, IL1L1, IL1RP3, IL-36Ra, IL36RA, PSORP, PSORS14

Human Chr (Location): 2q14; chr2:113058638-113064744 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IL36RN

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for a reporter allele are overtly normal with no apparent histopathological abnormalities or immune cell alterations. Mice homozygous for a knock-out allele exhibit increased sensitivity to IMQ-induced psoriasis.
 
Phenotype Images(1)
Interactions
Il1f5 interacts with 235 markers (Mir17, Mir18b, Mir20a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000011958 (Evidence)
Ensembl Gene Model ENSMUSG00000026983 (Evidence)
Entrez Gene 54450 (Evidence)
UniGene 29261
DFCI TC1585944, TC1633500, TC1694699
DoTS DT.101367367, DT.522869, DT.91337495
NIA Mouse Gene Index U001465
PDB 1MD6
Consensus CDS Project CCDS50519.1
International Mouse Phenotyping Consortium Status Il1f5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011958 VEGA Gene Model | MGI Sequence Detail 6473 C57BL/6J ±  kb
transcript OTTMUST00000028269 VEGA | MGI Sequence Detail 2842 Not Applicable 
polypeptide OTTMUSP00000012794 VEGA | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR000975 Interleukin-1 family
InterPro IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
InterPro IPR027171 Interleukin-36 receptor antagonist
Protein Ontology PR:000008988 interleukin-1 family member 5
References
(Earliest) J:61590 Kumar S, et al., Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 2000 Apr 7;275(14):10308-14
(Latest) J:193548 Tortola L, et al., Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest. 2012 Nov 1;122(11):3965-76
All references(40)
Other
accession IDs
MGI:2138922

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory