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Il36rn Gene Detail
Summary
  • Symbol
    Il36rn
  • Name
    interleukin 36 receptor antagonist
  • Synonyms
    FIL1delta, If36rn, Il1f5, IL1F5, IL-1H3, IL1HY1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859325
    NCBI Gene: 54450
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24166966-24172444 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 16.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859325
protein coding gene Chr2:24166966-24173438 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025406
protein coding gene Chr2:22071573-22076188 (+)
A/J MGP_AJ_G0025383
protein coding gene Chr2:21222480-21227095 (+)
AKR/J MGP_AKRJ_G0025353
protein coding gene Chr2:21951265-21955880 (+)
BALB/cJ MGP_BALBcJ_G0025379
protein coding gene Chr2:21331661-21336276 (+)
C3H/HeJ MGP_C3HHeJ_G0025140
protein coding gene Chr2:21888268-21892883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025823
protein coding gene Chr2:22781976-22786591 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023234
protein coding gene Chr2:20148196-20154708 (+)
CAST/EiJ MGP_CASTEiJ_G0024603
protein coding gene Chr2:21719598-21726066 (+)
CBA/J MGP_CBAJ_G0025118
protein coding gene Chr2:23586772-23591387 (+)
DBA/2J MGP_DBA2J_G0025251
protein coding gene Chr2:21081805-21086420 (+)
FVB/NJ MGP_FVBNJ_G0025213
protein coding gene Chr2:20820132-20827025 (+)
LP/J MGP_LPJ_G0025337
protein coding gene Chr2:22002792-22007407 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025244
protein coding gene Chr2:23823388-23828003 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025882
protein coding gene Chr2:21872422-21877037 (+)
PWK/PhJ MGP_PWKPhJ_G0024351
protein coding gene Chr2:20864688-20871472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024151
protein coding gene Chr2:21989115-21995624 (+)
WSB/EiJ MGP_WSBEiJ_G0024672
protein coding gene Chr2:21947094-21951709 (+)



Homology
more
  • Human Ortholog
    IL36RN, interleukin 36 receptor antagonist
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL36RN, interleukin 36 receptor antagonist
  • Synonyms
    FIL1, FIL1D, FIL1(DELTA), IL1F5, IL1HY1, IL1L1, IL1RP3, IL-36Ra, IL36RA, PSORP, PSORS14
  • Links
    NCBI Gene ID: 26525
    neXtProt AC: NX_Q9UBH0
    UniProt: Q9UBH0

  • Chr Location
    2q14.1; chr2:113058638-113064744 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IL36RN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele are overtly normal with no apparent histopathological abnormalities or immune cell alterations. Mice homozygous for a knock-out allele exhibit increased sensitivity to IMQ-induced psoriasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54450 NCBI Gene Model | MGI Sequence Detail 5479 C57BL/6J ±  kb
    transcript NM_001146087 RefSeq | MGI Sequence Detail 1848 C57BL/6  
    polypeptide Q9QYY1 UniProt | EBI | MGI Sequence Detail 156 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138922
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:57981 Mulero JJ, et al., IL1HY1: A novel interleukin-1 receptor antagonist gene. Biochem Biophys Res Commun. 1999 Oct 5;263(3):702-6
    • Latest
      J:327612 Hasegawa Y, et al., Neutrophil extracellular traps are involved in enhanced contact hypersensitivity response in IL-36 receptor antagonist-deficient mice. Sci Rep. 2022 Aug 4;12(1):13384

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/27/2022
    MGI 6.21
    The Jackson Laboratory