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Il1f5 Gene Detail
Summary
  • Symbol
    Il1f5
  • Name
    interleukin 1 family, member 5 (delta)
  • Synonyms
    FIL1delta, IL1F5, IL-1H3, IL1HY1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859325
    NCBI Gene: 54450
  • Gene Overview
    MyGene.info: IL36RN
Location & Maps
more
  • Sequence Map
    Chr2:24276954-24283426 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6473 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 16.31 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IL36RN, interleukin 36 receptor antagonist
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL36RN, interleukin 36 receptor antagonist
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FIL1, FIL1D, FIL1(DELTA), IL1F5, IL1HY1, IL1L1, IL1RP3, IL-36Ra, IL36RA, PSORP, PSORS14
  • Links
    NCBI Gene ID: 26525
    neXtProt AC: NX_Q9UBH0

  • Chr Location
    2q14; chr2:113058638-113064744 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL36RN associations

Human Disease Mouse Models
       Psoriasis 14, Pustular; PSORS14   OMIM: 614204
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
Mice homozygous for a reporter allele are overtly normal with no apparent histopathological abnormalities or immune cell alterations. Mice homozygous for a knock-out allele exhibit increased sensitivity to IMQ-induced psoriasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011958 VEGA Gene Model | MGI Sequence Detail 6473 C57BL/6J ±  kb
transcript OTTMUST00000028269 VEGA | MGI Sequence Detail 2842 Not Applicable  
polypeptide OTTMUSP00000012794 VEGA | MGI Sequence Detail 156 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008988 interleukin-1 family member 5
  • PDB
  • InterPro Domains
    IPR008996 Cytokine, IL-1-like
    IPR020877 Interleukin-1 conserved site
    IPR000975 Interleukin-1 family
    IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
    IPR027171 Interleukin-36 receptor antagonist
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
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MGI:2138922
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:61590 Kumar S, et al., Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 2000 Apr 7;275(14):10308-14
  • Latest
    J:193548 Tortola L, et al., Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest. 2012 Nov 1;122(11):3965-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory