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Il1f6 Gene Detail
Summary
  • Symbol
    Il1f6
  • Name
    interleukin 1 family, member 6
  • Synonyms
    Fil1, Fil1epsilon, IL-1H1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859324
    NCBI Gene: 54448
  • Gene Overview
    MyGene.info: IL36A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24215417-24225701 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 16.26 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859324
protein coding gene Chr2:24215417-24225702 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025405
protein coding gene Chr2:22000208-22010488 (+)
A/J MGP_AJ_G0025382
protein coding gene Chr2:21154128-21164304 (+)
AKR/J MGP_AKRJ_G0025351
protein coding gene Chr2:21872991-21883122 (+)
BALB/cJ MGP_BALBcJ_G0025377
protein coding gene Chr2:21266839-21277242 (+)
C3H/HeJ MGP_C3HHeJ_G0025138
protein coding gene Chr2:21818610-21833149 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025822
protein coding gene Chr2:22692358-22702652 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023233
protein coding gene Chr2:20108205-20115659 (+)
CAST/EiJ MGP_CASTEiJ_G0024601
protein coding gene Chr2:21627898-21638535 (-)
CBA/J MGP_CBAJ_G0025116
protein coding gene Chr2:23522718-23536376 (+)
DBA/2J MGP_DBA2J_G0025250
protein coding gene Chr2:21018654-21029721 (+)
FVB/NJ MGP_FVBNJ_G0025212
protein coding gene Chr2:20753304-20763451 (+)
LP/J MGP_LPJ_G0025335
protein coding gene Chr2:21934059-21948772 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025243
protein coding gene Chr2:23748792-23759388 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025881
protein coding gene Chr2:21796649-21806782 (+)
PWK/PhJ MGP_PWKPhJ_G0024350
protein coding gene Chr2:20804838-20815553 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024150
protein coding gene Chr2:21919154-21934239 (+)
WSB/EiJ MGP_WSBEiJ_G0024671
protein coding gene Chr2:21886605-21898076 (+)



Homology
more
  • Human Ortholog
    IL36A, interleukin 36 alpha
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IL36A, interleukin 36 alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FIL1, FIL1E, FIL1(EPSILON), IL1(EPSILON), IL1F6, IL-1F6
  • Links
    NCBI Gene ID: 27179
    neXtProt AC: NX_Q9UHA7
    UniProt: Q9UHA7

  • Chr Location
    2q14.1; chr2:113005461-113011071 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54448 NCBI Gene Model | MGI Sequence Detail 10285 C57BL/6J ±  kb
transcript NM_019450 RefSeq | MGI Sequence Detail 883 C57BL/6  
polypeptide Q9JLA2 UniProt | EBI | MGI Sequence Detail 160 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:61590 Kumar S, et al., Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 2000 Apr 7;275(14):10308-14
  • Latest
    J:233925 Nerlich A, et al., C/EBPbeta is a transcriptional key regulator of IL-36alpha in murine macrophages. Biochim Biophys Acta. 2015 Aug;1849(8):966-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory