Zftraf1 MGI Mouse Gene Detail - MGI:1859320 - zinc finger TRAF type containing 1

Symbol

Zftraf1
Name

zinc finger TRAF type containing 1
Synonyms

1110031M01Rik, Chrp, Cyhr1

Feature Type

protein coding gene
IDs

MGI:1859320
NCBI Gene: 54151
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:76531127-76541120 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.20 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

425 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859320	protein coding gene	Chr15:76527586-76541120 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022003	protein coding gene	Chr15:76735271-76753587 (-)
A/J	MGP_AJ_G0021961	protein coding gene	Chr15:73930809-73947524 (-)
AKR/J	MGP_AKRJ_G0021944	protein coding gene	Chr15:75937561-75954270 (-)
BALB/cJ	MGP_BALBcJ_G0021970	protein coding gene	Chr15:73956121-73973138 (-)
C3H/HeJ	MGP_C3HHeJ_G0021742	protein coding gene	Chr15:75982692-75999407 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022410	protein coding gene	Chr15:79597713-79618142 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019939	protein coding gene	Chr15:70587098-70603766 (-)
CAST/EiJ	MGP_CASTEiJ_G0021261	protein coding gene	Chr15:76787148-76803899 (-)
CBA/J	MGP_CBAJ_G0021709	protein coding gene	Chr15:82125587-82142410 (-)
DBA/2J	MGP_DBA2J_G0021834	protein coding gene	Chr15:73467977-73484699 (-)
FVB/NJ	MGP_FVBNJ_G0021814	protein coding gene	Chr15:72525450-72542668 (-)
LP/J	MGP_LPJ_G0021905	protein coding gene	Chr15:76825299-76842043 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021839	protein coding gene	Chr15:87456304-87473868 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022430	protein coding gene	Chr15:76212395-76229156 (-)
PWK/PhJ	MGP_PWKPhJ_G0021002	protein coding gene	Chr15:73631898-73649385 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020842	protein coding gene	Chr15:75905948-75922767 (-)
WSB/EiJ	MGP_WSBEiJ_G0021313	protein coding gene	Chr15:76299415-76316130 (-)

Human Ortholog

ZFTRAF1, zinc finger TRAF-type containing 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFTRAF1, zinc finger TRAF-type containing 1
Synonyms

CHRP, CYHR1
Links

HGNC:17806

NCBI Gene ID: 50626

UniProt: P0DTL6
Chr Location

8q24.3; chr8:144449582-144462871 (-) GRCh38

MGI Vertebrate Homology

Zftraf1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: ZFTRAF1
Gene Tree

Zftraf1

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

3
Endonuclease-mediated

1
Radiation induced

2
Targeted

2
Genomic Mutations

5 involving Zftraf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem276

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All Sequences

62
RefSeq

12
CCDS

CCDS70643.1

Ensembl

ENSMUSG00000053929 (Evidence)
NCBI Gene

54151

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053929	Ensembl Gene Model \| MGI Sequence Detail	9994	C57BL/6J	± kb
transcript	ENSMUST00000176274	Ensembl \| MGI Sequence Detail	1854	Not Applicable
polypeptide	ENSMUSP00000134739	Ensembl \| MGI Sequence Detail	412	Not Applicable

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Protein Ontology

PR:000059671 zinc finger TRAF-type-containing protein 1

(term hierarchy)

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All nucleic 17

cDNA 17

Microarray probesets 11

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MGI:2146152, MGI:2447817, MGI:7414093

Summaries

All 54

Diseases 1

Gene Ontology 5

Phenotypes 28
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zftraf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135037	Chr15:76541105-76541134 (-)	0 bp
Tssr135036	Chr15:76540950-76540969 (-)	160 bp
Tssr135035	Chr15:76540935-76540947 (-)	179 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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