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Barhl2
Gene Detail
Symbol

Name
ID
Barhl2
BarH-like 2 (Drosophila)
MGI:1859314
Synonyms
E130309B19Rik, MBH1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
51.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:106452523-106458451 bp, - strand
From VEGA annotation of GRCm38

  5929 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BARHL2
Gene Tree: Barhl2

Human
homologs
BARHL2, BarH-like homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 343472
neXtProt AC: NX_Q9NY43

Human Chr (Location): 1p22.2; chr1:90712022-90717237 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele display postnatal lethality with slow weight gain, impaired coordination, decreased numbers of retinal ganglion cells and retinal amacrine cells, and abnormal eye electrophysiology.
 
Interactions
Barhl2 interacts with 154 markers (Mir15b, Mir16-1, Mir19a, ...)
Expression
Literature Summary: (25 records)
Data Summary: Results (271)    Tissues (140)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 270
RT-PCR 1
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase barhl2 ; ZFIN barhl2    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000026737 (Evidence)
Ensembl Gene Model ENSMUSG00000034384 (Evidence)
Entrez Gene 104382 (Evidence)
UniGene 271593
DFCI TC1586103
DoTS DT.101200920, DT.91319030
NIA Mouse Gene Index U026506
Consensus CDS Project CCDS19497.1
International Mouse Phenotyping Consortium Status Barhl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026737 VEGA Gene Model | MGI Sequence Detail 5929 C57BL/6J ±  kb
transcript OTTMUST00000066129 VEGA | MGI Sequence Detail 2314 Not Applicable 
polypeptide OTTMUSP00000033083 VEGA | MGI Sequence Detail 384 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000004644 BarH-like 2 homeobox protein
References
(Earliest) J:62505 Bulfone A, et al., Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. Hum Mol Genet. 2000 May 22;9(9):1443-52
(Latest) J:208848 Duval N, et al., Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord. Development. 2014 Apr;141(8):1726-36
All references(51)
Other
accession IDs
MGI:3036272

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory