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Barhl2
Gene Detail
 Symbol
Name
ID
Barhl2
BarH-like 2 (Drosophila)
MGI:1859314
Synonyms E130309B19Rik, MBH1
Feature Type protein coding gene
Genetic Map
Chromosome 5
51.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:106452514-106458440 bp, - strand
From VEGA annotation of GRCm38

  5927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Barhl2

Human
homologs
Human Homolog BARHL2, BarH-like homeobox 2
NCBI Gene ID 343472
neXtProt AC  NX_Q9NY43
Human Chr (Location)  1p22.2; chr1:90712022-90717237 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display postnatal lethality with slow weight gain, impaired coordination, decreased numbers of retinal ganglion cells and retinal amacrine cells, and abnormal eye electrophysiology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell fate commitment, cell fate determination, ...
Component cytoplasm, nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (271)    Tissues (140)    Images (58)
Theiler Stages: 15, 17, 19, 20, 22, 23
Assay TypeResults
RNA in situ 270
RT-PCR 1
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000026737 (Evidence)
Ensembl Gene ModelENSMUSG00000034384 (Evidence)
Entrez Gene104382 (Evidence)
UniGene271593
DFCITC1586103
DoTSDT.101200920, DT.91319030
NIA Mouse Gene IndexU026506
Consensus CDS ProjectCCDS19497.1
International Mouse Knockout Project StatusBarhl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026737 VEGA Gene Model | MGI Sequence Detail 5927 C57BL/6J ±  kb
transcript OTTMUST00000066129 VEGA | MGI Sequence Detail 2597 Not Applicable 
polypeptide OTTMUSP00000033083 VEGA | MGI Sequence Detail 384 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000004644 BarH-like 2 homeobox protein
References (Earliest) J:62505 Bulfone A, et al., Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. Hum Mol Genet. 2000 May 22;9(9):1443-52
(Latest) J:181907 Ding Q, et al., BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1566-71
All references(48)
Other
accession IDs
MGI:3036272

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory