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Barhl2 Gene Detail
Summary
  • Symbol
    Barhl2
  • Name
    BarH like homeobox 2
  • Synonyms
    E130309B19Rik, MBH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859314
    NCBI Gene: 104382
  • Gene Overview
    MyGene.info: BARHL2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:106452523-106458166 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 51.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859314
protein coding gene Chr5:106452523-106458166 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029829
protein coding gene Chr5:108412170-108417793 (-)
A/J MGP_AJ_G0029793
protein coding gene Chr5:104262579-104268219 (-)
AKR/J MGP_AKRJ_G0029738
protein coding gene Chr5:107652318-107657943 (-)
BALB/cJ MGP_BALBcJ_G0029805
protein coding gene Chr5:105405567-105411195 (-)
C3H/HeJ MGP_C3HHeJ_G0029527
protein coding gene Chr5:108098519-108104137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030259
protein coding gene Chr5:112917977-112923620 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027494
protein coding gene Chr5:99349023-99354646 (-)
CAST/EiJ MGP_CASTEiJ_G0028941
protein coding gene Chr5:106993812-106999441 (-)
CBA/J MGP_CBAJ_G0029495
protein coding gene Chr5:116683384-116689000 (-)
DBA/2J MGP_DBA2J_G0029641
protein coding gene Chr5:104417475-104423105 (-)
FVB/NJ MGP_FVBNJ_G0029598
protein coding gene Chr5:103139562-103145440 (-)
LP/J MGP_LPJ_G0029729
protein coding gene Chr5:108992277-108997901 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029630
protein coding gene Chr5:121651926-121657537 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030293
protein coding gene Chr5:107182096-107187705 (-)
PWK/PhJ MGP_PWKPhJ_G0028654
protein coding gene Chr5:103203233-103209018 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028492
protein coding gene Chr5:104700438-104706013 (-)
WSB/EiJ MGP_WSBEiJ_G0029014
protein coding gene Chr5:107506103-107511711 (-)



Homology
more
  • Human Ortholog
    BARHL2, BarH like homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BARHL2, BarH like homeobox 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 343472
    neXtProt AC: NX_Q9NY43
    UniProt: Q9NY43

  • Chr Location
    1p22.2; chr1:90712022-90717237 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display postnatal lethality with slow weight gain, impaired coordination, decreased numbers of retinal ganglion cells and retinal amacrine cells, and abnormal eye electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104382 NCBI Gene Model | MGI Sequence Detail 5644 C57BL/6J ±  kb
    transcript NM_001005477 RefSeq | MGI Sequence Detail 2329 C57BL/6  
    polypeptide Q8VIB5 UniProt | EBI | MGI Sequence Detail 384 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3036272
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 34
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:253958 Fujimura N, et al., Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation. Dev Biol. 2018 Jan 1;433(1):47-60

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory