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Asah2 Gene Detail
Summary
  • Symbol
    Asah2
  • Name
    N-acylsphingosine amidohydrolase 2
  • Synonyms
    neutral/alkaline ceramidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859310
    NCBI Gene: 54447
  • Gene Overview
    MyGene.info: ASAH2
Location & Maps
more
  • Sequence Map
    Chr19:31984654-32061469 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76816 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 26.58 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ASAH2, N-acylsphingosine amidohydrolase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ASAH2, N-acylsphingosine amidohydrolase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCDase, HNAC1, LCDase, NCDase, N-CDase
  • Links
    NCBI Gene ID: 56624
    neXtProt AC: NX_Q9NR71

  • Chr Location
    10q11.21; chr10:50182778-50251577 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are defective in the intestinal digestion of dietary ceramide but exhibit a normal life span with no obvious abnormalities or significant alterations in total ceramide levels in major organ tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024887 Ensembl Gene Model | MGI Sequence Detail 76816 C57BL/6J ±  kb
transcript ENSMUST00000096119 Ensembl | MGI Sequence Detail 4682 Not Applicable  
polypeptide ENSMUSP00000093830 Ensembl | MGI Sequence Detail 756 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    760 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004337 neutral ceramidase
  • EC
  • InterPro Domains
    IPR006823 Neutral/alkaline nonlysosomal ceramidase
    IPR031331 Neutral/alkaline non-lysosomal ceramidase, C-terminal
    IPR031329 Neutral/alkaline non-lysosomal ceramidase, N-terminal
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147579
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:61655 Tani M, et al., Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000 Apr 14;275(15):11229-34
  • Latest
    J:231605 Novgorodov SA, et al., Lactosylceramide contributes to mitochondrial dysfunction in diabetes. J Lipid Res. 2016 Apr;57(4):546-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory