Asah2
Gene Detail

Symbol Name ID

Asah2 N-acylsphingosine amidohydrolase 2 MGI:1859310

Synonyms

neutral/alkaline ceramidase

Feature Type

protein coding gene

Genetic Map

Chromosome 19

26.58 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:31984654-32061469 bp, - strand From Ensembl annotation of GRCm38   76816 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10310  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neutral/alkaline ceramidase
Gene Tree: Asah2

Human homologs

Human Homolog		ASAH2, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
NCBI Gene ID		56624
neXtProt AC		NX_Q9NR71
Human Synonyms		BCDase, HNAC1, LCDase, NCDase, N-CDase
Human Chr (Location)		10q11.21; chr10:51947000-52008370 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a targeted null mutation are defective in the intestinal digestion of dietary ceramide but exhibit a normal life span with no obvious abnormalities or significant alterations in total ceramide levels in major organ tissues.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	apoptotic process, cell proliferation, ...
Component	integral to membrane, membrane, ...
Function	ceramidase activity, hydrolase activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(24)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000024887 (Evidence)
Entrez Gene	54447 (Evidence)
UniGene	104900
DFCI	TC1583265, TC1618581
DoTS	DT.40148545, DT.91355033, DT.94294125, DT.94393735
NIA Mouse Gene Index	U038968
EC	3.5.1.23
Consensus CDS Project	CCDS29749.1
International Mouse Knockout Project Status	Asah2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024887	Ensembl Gene Model | MGI Sequence Detail	76816	C57BL/6J
transcript	ENSMUST00000096119	Ensembl | MGI Sequence Detail	4682	Not Applicable
polypeptide	ENSMUSP00000093830	Ensembl | MGI Sequence Detail	756	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(489 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006823	Neutral/alkaline nonlysosomal ceramidase
Protein Ontology	PR:000004337	neutral ceramidase

References

(Earliest) J:61655 Tani M, et al., Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000 Apr 14;275(15):11229-34
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)

Other accession IDs

MGI:2147579