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Atxn10 Gene Detail
Summary
  • Symbol
    Atxn10
  • Name
    ataxin 10
  • Synonyms
    E46, Sca10, TEG-169, Tex169
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859293
    NCBI Gene: 54138
  • Gene Overview
    MyGene.info: ATXN10
Location & Maps
more
  • Sequence Map
    Chr15:85336381-85463836 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      127456 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ATXN10, ataxin 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATXN10, ataxin 10
    Orthology source: HomoloGene
  • Synonyms
    E46L, HUMEEP, SCA10
  • Links
    NCBI Gene ID: 25814
    neXtProt AC: NX_Q9UBB4

  • Chr Location
    22q13.31; chr22:45671798-45845307 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ATXN10 associations

Human Disease Mouse Models
       Spinocerebellar Ataxia 10; SCA10   OMIM: 603516 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Radiation induced
    2
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    3 involving Atxn10
  • Incidental Mutations
Homozygous null mice die at early postimplantation stages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54138 NCBI Gene Model | MGI Sequence Detail 127456 C57BL/6J ±  kb
transcript NM_016843 RefSeq | MGI Sequence Detail 2425 C57BL/6  
polypeptide P28658 UniProt | EBI | MGI Sequence Detail 475 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    725 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 7
Other
Accession IDs
less
MGI:1096568, MGI:2145984, MGI:2146273
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Diseases 3
    Gene Ontology 3
    Phenotypes 32
  • Earliest
    J:35463 Lopez-Fernandez LA, et al., Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. Mamm Genome. 1996 Sep;7(9):698-700
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory