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Atxn10 Gene Detail
Summary
  • Symbol
    Atxn10
  • Name
    ataxin 10
  • Synonyms
    E46, Sca10, TEG-169, Tex169
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859293
    NCBI Gene: 54138
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:85220446-85347413 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 40.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    714 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859293
protein coding gene Chr15:85220446-85348038 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022191
protein coding gene Chr15:86196280-86332605 (+)
A/J MGP_AJ_G0022150
protein coding gene Chr15:82991926-83125166 (+)
AKR/J MGP_AKRJ_G0022125
protein coding gene Chr15:85438706-85580147 (+)
BALB/cJ MGP_BALBcJ_G0022156
protein coding gene Chr15:83119463-83250611 (+)
C3H/HeJ MGP_C3HHeJ_G0021926
protein coding gene Chr15:85383035-85520562 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022601
protein coding gene Chr15:89444176-89578723 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020126
protein coding gene Chr15:79326866-79452277 (+)
CAST/EiJ MGP_CASTEiJ_G0021448
protein coding gene Chr15:86179003-86318635 (+)
CBA/J MGP_CBAJ_G0021893
protein coding gene Chr15:92398538-92543210 (+)
DBA/2J MGP_DBA2J_G0022020
protein coding gene Chr15:82461109-82588273 (+)
FVB/NJ MGP_FVBNJ_G0021999
protein coding gene Chr15:81529392-81659479 (+)
LP/J MGP_LPJ_G0022091
protein coding gene Chr15:86367749-86498731 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022019
protein coding gene Chr15:97119718-97257030 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022616
protein coding gene Chr15:85440731-85576847 (+)
PWK/PhJ MGP_PWKPhJ_G0021189
protein coding gene Chr15:82469594-82597675 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021023
protein coding gene Chr15:85133913-85279170 (+)
WSB/EiJ MGP_WSBEiJ_G0021497
protein coding gene Chr15:85937888-86072733 (+)



Homology
more
  • Human Ortholog
    ATXN10, ataxin 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATXN10, ataxin 10
  • Synonyms
    ATX10, E46L, HUMEEP, SCA10
  • Links
    NCBI Gene ID: 25814
    neXtProt AC: NX_Q9UBB4
    UniProt: Q9UBB4

  • Chr Location
    22q13.31; chr22:45671798-45845307 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ATXN10 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    20
  • Radiation induced
    2
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    3 involving Atxn10
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygous null mice die at early postimplantation stages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016541 Ensembl Gene Model | MGI Sequence Detail 126968 C57BL/6J ±  kb
transcript ENSMUST00000163242 Ensembl | MGI Sequence Detail 1937 Not Applicable  
polypeptide ENSMUSP00000132450 Ensembl | MGI Sequence Detail 475 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 7
Other
Accession IDs
less
MGI:1096568, MGI:2145984, MGI:2146273
References
more
  • Summaries
    All 69
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 4
    Phenotypes 37
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:316878 Bentley-Ford MR, et al., ATXN10 Is Required for Embryonic Heart Development and Maintenance of Epithelial Cell Phenotypes in the Adult Kidney and Pancreas. Front Cell Dev Biol. 2021;9:705182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory