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Barhl1 Gene Detail
Summary
  • Symbol
    Barhl1
  • Name
    BarH-like 1 (Drosophila)
  • Synonyms
    Dres115, MBH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859288
    NCBI Gene: 54422
Location & Maps
more
  • Sequence Map
    Chr2:28907679-28916668 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8990 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BARHL1, BarH like homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BARHL1, BarH like homeobox 1
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 56751
    neXtProt AC: NX_Q9BZE3

  • Chr Location
    9q34; chr9:132582606-132590253 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in progressive hearing loss starting at 2 weeks of age. Animals are completely deaf by 10 months of age and show degeneration of the inner and outer cochlear hair cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011821 VEGA Gene Model | MGI Sequence Detail 8990 C57BL/6J ±  kb
transcript OTTMUST00000027754 VEGA | MGI Sequence Detail 3666 Not Applicable  
polypeptide OTTMUSP00000012610 VEGA | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 70
    Developmental Gene Expression 44
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:62505 Bulfone A, et al., Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. Hum Mol Genet. 2000 May 22;9(9):1443-52
  • Latest
    J:226611 Hillmer RE, et al., Generation and characterization of mice harboring a conditional CXCL12 allele. Int J Dev Biol. 2015;59(4-6):205-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory