Cldn8 MGI Mouse Gene Detail - MGI:1859286

Symbol

Cldn8
Name

claudin 8

Feature Type

protein coding gene
IDs

MGI:1859286
NCBI Gene: 54420
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr16:88357716-88360071 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 51.22 cM
Mapping Data

1 experiment

SNPs within 2kb

65 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859286	protein coding gene	Chr16:88357714-88360071 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022984	protein coding gene	Chr16:89364730-89367083 (-)
A/J	MGP_AJ_G0022952	protein coding gene	Chr16:85220370-85222725 (-)
AKR/J	MGP_AKRJ_G0022922	protein coding gene	Chr16:87805689-87808044 (-)
BALB/cJ	MGP_BALBcJ_G0022954	protein coding gene	Chr16:85750642-85752997 (-)
C3H/HeJ	MGP_C3HHeJ_G0022716	protein coding gene	Chr16:88373228-88375583 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023401	protein coding gene	Chr16:92238457-92240812 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020905	protein coding gene	Chr16:83053430-83055770 (-)
CAST/EiJ	MGP_CASTEiJ_G0022238	protein coding gene	Chr16:88805664-88808012 (-)
CBA/J	MGP_CBAJ_G0022685	protein coding gene	Chr16:96192392-96194747 (-)
DBA/2J	MGP_DBA2J_G0022819	protein coding gene	Chr16:85145143-85147498 (-)
FVB/NJ	MGP_FVBNJ_G0022794	protein coding gene	Chr16:84248911-84251266 (-)
LP/J	MGP_LPJ_G0022888	protein coding gene	Chr16:89049516-89051869 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022813	protein coding gene	Chr16:100722558-100724913 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023419	protein coding gene	Chr16:88313620-88315974 (-)
PWK/PhJ	MGP_PWKPhJ_G0021981	protein coding gene	Chr16:85299967-85302328 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021811	protein coding gene	Chr16:87867145-87869504 (-)
WSB/EiJ	MGP_WSBEiJ_G0022286	protein coding gene	Chr16:88535161-88537516 (-)

Human Ortholog

CLDN8, claudin 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLDN8, claudin 8
Synonyms

HEL-S-79
Links

HGNC:2050

NCBI Gene ID: 9073

neXtProt AC: NX_P56748

UniProt: P56748
Chr Location

21q22.11; chr21:30214006-30216151 (-) GRCh38.p7

Alliance of Genome Resources

Cldn8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CLDN8
Gene Tree

Cldn8

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
1 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Targeted

6
Genomic Mutations

3 involving Cldn8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1048
Tissues

252
cDNA Data

48
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cldn8.1, cldn8.4

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Cldn8 interacts with 231 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS28296.1

Ensembl

ENSMUSG00000050520 (Evidence)
NCBI Gene

54420

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050520	Ensembl Gene Model \| MGI Sequence Detail	2356	C57BL/6J	± kb
transcript	ENSMUST00000049697	Ensembl \| MGI Sequence Detail	2356	Not Applicable
polypeptide	ENSMUSP00000051887	Ensembl \| MGI Sequence Detail	225	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005556 claudin-8

(term hierarchy)
InterPro Domains

IPR006187 Claudin

IPR003926 Claudin-8

IPR017974 Claudin, conserved site

IPR004031 PMP-22/EMP/MP20/Claudin superfamily

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All nucleic 54

cDNA 48

Primer pair 5

Other 1

Microarray probesets 5

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MGI:2146473

Summaries

All 55

Developmental Gene Expression 19

Gene Ontology 8

Phenotypes 9
Earliest

J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
Latest

J:313345 Higashi AY, et al., Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. Sci Rep. 2021 Nov 4;11(1):21642

TSS for Cldn8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141963	Chr16:88360089-88360102 (-)	-25 bp
Tssr141962	Chr16:88360054-88360088 (-)	0 bp
Tssr141961	Chr16:88360037-88360052 (-)	26 bp
Tssr141960	Chr16:88360032-88360035 (-)	37 bp
Tssr141959	Chr16:88360018-88360029 (-)	47 bp
Tssr141958	Chr16:88359995-88360006 (-)	70 bp
Tssr141957	Chr16:88359946-88359958 (-)	119 bp
Tssr141956	Chr16:88359907-88359914 (-)	160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/23/2022 MGI 6.20