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Cldn8 Gene Detail
Summary
  • Symbol
    Cldn8
  • Name
    claudin 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859286
    NCBI Gene: 54420
  • Gene Overview
    MyGene.info: CLDN8
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:88560828-88563183 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 51.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859286
protein coding gene Chr16:88560826-88563183 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022984
protein coding gene Chr16:89364730-89367083 (-)
A/J MGP_AJ_G0022952
protein coding gene Chr16:85220370-85222725 (-)
AKR/J MGP_AKRJ_G0022922
protein coding gene Chr16:87805689-87808044 (-)
BALB/cJ MGP_BALBcJ_G0022954
protein coding gene Chr16:85750642-85752997 (-)
C3H/HeJ MGP_C3HHeJ_G0022716
protein coding gene Chr16:88373228-88375583 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023401
protein coding gene Chr16:92238457-92240812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020905
protein coding gene Chr16:83053430-83055770 (-)
CAST/EiJ MGP_CASTEiJ_G0022238
protein coding gene Chr16:88805664-88808012 (-)
CBA/J MGP_CBAJ_G0022685
protein coding gene Chr16:96192392-96194747 (-)
DBA/2J MGP_DBA2J_G0022819
protein coding gene Chr16:85145143-85147498 (-)
FVB/NJ MGP_FVBNJ_G0022794
protein coding gene Chr16:84248911-84251266 (-)
LP/J MGP_LPJ_G0022888
protein coding gene Chr16:89049516-89051869 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022813
protein coding gene Chr16:100722558-100724913 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023419
protein coding gene Chr16:88313620-88315974 (-)
PWK/PhJ MGP_PWKPhJ_G0021981
protein coding gene Chr16:85299967-85302328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021811
protein coding gene Chr16:87867145-87869504 (-)
WSB/EiJ MGP_WSBEiJ_G0022286
protein coding gene Chr16:88535161-88537516 (-)



Homology
more
  • Human Ortholog
    CLDN8, claudin 8
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CLDN8, claudin 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-79
  • Links
    NCBI Gene ID: 9073
    neXtProt AC: NX_P56748
    UniProt: P56748

  • Chr Location
    21q22.11; chr21:30214006-30216151 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050520 Ensembl Gene Model | MGI Sequence Detail 2356 C57BL/6J ±  kb
    transcript ENSMUST00000049697 Ensembl | MGI Sequence Detail 2356 Not Applicable  
    polypeptide ENSMUSP00000051887 Ensembl | MGI Sequence Detail 225 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 48
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146473
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 15
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory