About   Help   FAQ
Cldn7
Gene Detail
 Symbol
Name
ID
Cldn7
claudin 7
MGI:1859285
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.94 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:69964779-69967885 bp, + strand
From VEGA annotation of GRCm38

  3107 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Cldn7

Human
homologs
Human Homolog CLDN7, claudin 7
NCBI Gene ID 1366
neXtProt AC  NX_O95471
Human Synonyms  CEPTRL2, claudin-1, CLDN-7, CPETRL2, Hs.84359
Human Chr (Location)  17p13.1; chr17:7259903-7263193 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
 
Mice homozygous for a knock-out allele exhibit decreased body size, weight, and length; abnormal potassium, chloride, and sodium ion excretion; chronic dehydration; and postnatal lethality by P12.
 
Interactions
Cldn7 interacts with 57 markers (Mir98, Mir150, Mir297a-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Component basolateral plasma membrane, cell junction, ...
Function protein binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (119)    Tissues (28)    Images (31)
Theiler Stages: 3, 5, 13, 22, 23, 24, 26, 27
Assay TypeResults
Immunohistochemistry 3
RNA in situ 109
Western blot 1
RT-PCR 6
cDNA source data(167)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(172) cDNA(167) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006019 (Evidence)
Ensembl Gene ModelENSMUSG00000018569 (Evidence)
Entrez Gene53624 (Evidence)
UniGene281896
DFCITC1575174
DoTSDT.534929
NIA Mouse Gene IndexU012837
Consensus CDS ProjectCCDS24925.1
International Mouse Knockout Project StatusCldn7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006019 VEGA Gene Model | MGI Sequence Detail 3107 C57BL/6J ±  kb
transcript OTTMUST00000013494 VEGA | MGI Sequence Detail 1335 Not Applicable 
polypeptide OTTMUSP00000006253 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003552 Claudin-7
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005555 claudin-7
References (Earliest) J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(57)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory