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Cldn7 Gene Detail
Summary
  • Symbol
    Cldn7
  • Name
    claudin 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859285
    NCBI Gene: 53624
  • Gene Overview
    MyGene.info: CLDN7
Location & Maps
more
  • Sequence Map
    Chr11:69964779-69967885 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3107 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CLDN7, claudin 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLDN7, claudin 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CEPTRL2, claudin-1, CLDN-7, CPETRL2, Hs.84359
  • Links
    NCBI Gene ID: 1366
    neXtProt AC: NX_O95471

  • Chr Location
    17p13.1; chr17:7259903-7263193 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    2 involving Cldn7
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased body size, weight, and length; abnormal potassium, chloride, and sodium ion excretion; chronic dehydration; and postnatal lethality by P12.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006019 VEGA Gene Model | MGI Sequence Detail 3107 C57BL/6J ±  kb
transcript OTTMUST00000013494 VEGA | MGI Sequence Detail 1335 Not Applicable  
polypeptide OTTMUSP00000006253 VEGA | MGI Sequence Detail 211 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 173
    cDNA 168
    Primer pair 4
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 57
    Developmental Gene Expression 19
    Gene Ontology 10
    Phenotypes 14
  • Earliest
    J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
  • Latest
    J:210997 Ihermann-Hella A, et al., Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet. 2014 Mar;10(3):e1004193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory