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Cldn7
Gene Detail
Symbol

Name
ID
Cldn7
claudin 7
MGI:1859285
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.94 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:69964779-69967885 bp, + strand
From VEGA annotation of GRCm38

  3107 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

HCOP human homology predictions: CLDN7
Gene Tree: Cldn7

Human
homologs
CLDN7, claudin 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1366
neXtProt AC: NX_O95471

Human Synonyms: CEPTRL2, claudin-1, CLDN-7, CPETRL2, Hs.84359

Human Chr (Location): 17p13.1; chr17:7259903-7263193 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Genomic Mutations involving Cldn7 (1)
Incidental mutations (data from CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased body size, weight, and length; abnormal potassium, chloride, and sodium ion excretion; chronic dehydration; and postnatal lethality by P12.
 
Interactions
Cldn7 interacts with 57 markers (Mir98, Mir150, Mir297a-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (123)    Tissues (32)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 113
Western blot 1
RT-PCR 6
cDNA source data(168)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cldn7 ; ZFIN cldn7b    NEW 
Molecular
reagents
All nucleic(173) cDNA(168) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006019 (Evidence)
Ensembl Gene Model ENSMUSG00000018569 (Evidence)
Entrez Gene 53624 (Evidence)
UniGene 281896
DFCI TC1575174
DoTS DT.534929
NIA Mouse Gene Index U012837
Consensus CDS Project CCDS24925.1
International Mouse Phenotyping Consortium Status Cldn7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006019 VEGA Gene Model | MGI Sequence Detail 3107 C57BL/6J ±  kb
transcript OTTMUST00000013494 VEGA | MGI Sequence Detail 1335 Not Applicable 
polypeptide OTTMUSP00000006253 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003552 Claudin-7
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005555 claudin-7
References
(Earliest) J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
(Latest) J:210997 Ihermann-Hella A, et al., Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet. 2014 Mar;10(3):e1004193
All references(60)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory